NRG1 and ERBB4

Number of citations of the paper that reports this interaction (PMID 9168115)
48

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		NRG1	ERBB4
Gene Name		neuregulin 1	erb-b2 receptor tyrosine kinase 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Axon Neuromuscular Junction	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Transcription Cofactor Activity Receptor Binding Cytokine Activity ErbB-2 Class Receptor Binding Protein Binding Growth Factor Activity Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding ErbB-3 Class Receptor Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	MAPK Cascade Cell Morphogenesis Cardiac Conduction System Development Ventricular Trabecula Myocardium Morphogenesis Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Synapse Assembly Peripheral Nervous System Development Locomotory Behavior Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryo Development Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Cell Migration Glial Cell Fate Commitment Positive Regulation Of Cell Growth Mammary Gland Development Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway ERBB Signaling Pathway Wound Healing Negative Regulation Of Protein Catabolic Process Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Cellular Protein Complex Disassembly Innate Immune Response Neurotransmitter Receptor Metabolic Process Positive Regulation Of Cell Adhesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Neuron Fate Commitment Negative Regulation Of Secretion Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Endocardial Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Heart Development Lactation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryonic Pattern Specification Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Signal Transduction By Phosphorylation Regulation Of Cell Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Mitochondrial Fragmentation Involved In Apoptotic Process Innate Immune Response Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cardiac Muscle Tissue Regeneration Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of STAT Protein Import Into Nucleus
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143) Dialysis-related mortality ( 21546767) Hip geometry ( 17903296) Hirschsprung's disease ( 19196962) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906)	Breast cancer ( 22452962) Type 1 diabetes nephropathy ( 23028342)
Protein-Protein Interactions		7 interactors: ADAM19 EGF ERBB2 ERBB3 ERBB4 IKZF4 LIMK1	39 interactors: ABL1 ABL2 ADAM17 ANKS1A ANKS1B BTC CD44 CRK CTGF DLG1 DLG2 DLG3 DLG4 EGFR ERBB2 ERBB3 EREG GRB2 HBEGF HDAC6 ITCH MUC1 NEDD4 NRG1 NRG2 NRG3 NRG4 PIK3R2 RASA1 RNF41 SHC1 SNTB2 STAT5A STAT5B SYK TAB2 TGFA TRO YAP1
Entrez ID		3084	2066
HPRD ID		00802	02767
Ensembl ID		ENSG00000157168	ENSG00000178568
Uniprot IDs		A6MW55 A6MW56 B0FWZ3 B0FYA7 B0FYA8 B0FYA9 B7Z1D7 B7Z1E3 Q02297 Q6PK61 Q7RTW3 Q7RTW5	Q15303
PDB IDs		1HAE 1HAF 1HRE 1HRF 3U7U	2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U 3U9U
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Innate Immune Response Cardiovascular System Development Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Kinase Activity Heart Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Immune Response Regulation Of Immune System Process Protein Phosphorylation Positive Regulation Of Transferase Activity Defense Response Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Phosphatidylinositol 3-kinase Signaling Regulation Of Peptidyl-tyrosine Phosphorylation Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Growth Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Phosphorylation Phosphorylation Signal Transduction By Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Immune System Process Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Tyrosine Kinase Activity	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cell Communication Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Growth Factor Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Innate Immune Response Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Cellular Response To Stimulus Regulation Of Phosphorylation Immune System Process Phosphatidylinositol-mediated Signaling Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Defense Response Response To Stimulus System Development Cellular Response To Organic Substance Response To Stress Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Multicellular Organismal Development Regulation Of Cellular Component Organization Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of MAPK Cascade
Tagcloud ?		appreciated cardiac cardiomyocyte cardiomyocytes cardiomyopathy chamber conscious contractility dilatation dilated dilation echocardiography ecs ejection erbb fractional hearts isoproterenol mechanistically neuregulin normalization normalized paracrine pecam proper shortening systolic tightly	180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane
Tagcloud (Difference) ?		appreciated cardiac cardiomyocyte cardiomyocytes cardiomyopathy chamber conscious contractility dilatation dilated dilation echocardiography ecs ejection erbb fractional hearts isoproterenol mechanistically neuregulin normalization normalized paracrine pecam proper shortening systolic tightly	180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane
Tagcloud (Intersection) ?