HFE and TFR2

Number of citations of the paper that reports this interaction (PMID 9465039)
99

Data Source:
HPRD (in vivo)

		HFE	TFR2
Gene Name		hemochromatosis	transferrin receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle MHC Class I Protein Complex Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome	Cytoplasm Integral Component Of Plasma Membrane
	Molecular Function	Antigen Binding Receptor Binding Protein Binding Peptide Antigen Binding	Transferrin Receptor Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Complex Assembly Cellular Iron Ion Homeostasis Immune Response Female Pregnancy Cellular Response To Iron Ion Starvation Antigen Processing And Presentation Hormone Biosynthetic Process Multicellular Organismal Iron Ion Homeostasis Iron Ion Import Into Cell	Iron Ion Transport Cellular Iron Ion Homeostasis Receptor-mediated Endocytosis
Pathways
Drugs
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Blood pressure ( 21909110) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 20686565) Diastolic blood pressure ( 21909115) Glycated hemoglobin levels ( 20858683) Hematocrit ( 19862010) Hematological parameters ( 19820697) Hematology traits ( 23263863 19853236) Hemoglobin ( 19820698 19862010) Hepcidin levels ( 21785125) Hypertension ( 21909115) Iron levels ( 21208937) Iron status biomarkers ( 21483845 21149283 19820699 19084217) LDL cholesterol ( 20686565) Mean corpuscular hemoglobin ( 23263863) Mean corpuscular volume ( 20139978 19862010) Red blood cell traits ( 23446634 20927387 23222517) Systolic blood pressure ( 21909115)	Hematocrit ( 19862010) Hematological parameters ( 19820697) Iron levels ( 21208937) Mean corpuscular volume ( 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		3 interactors: B2M TFR2 TFRC	3 interactors: HFE SOCS3 TF
Entrez ID		3077	7036
HPRD ID		01993	05282
Ensembl ID		ENSG00000010704	ENSG00000106327
Uniprot IDs		Q30201 Q6B0J5	Q9UP52
PDB IDs		1A6Z 1C42 1DE4
Enriched GO Terms of Interacting Partners?		Iron Ion Homeostasis Transition Metal Ion Homeostasis Metal Ion Homeostasis Ion Homeostasis Iron Ion Transport Cellular Iron Ion Homeostasis Chemical Homeostasis Homeostatic Process Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Leukocyte Differentiation Receptor-mediated Endocytosis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To Drug Cellular Chemical Homeostasis Viral Process Iron Ion Import Positive Regulation Of Bone Resorption Hemopoiesis Endocytosis Protein Refolding Cellular Homeostasis Immune System Development Regulation Of Defense Response To Virus By Virus Positive Regulation Of Tissue Remodeling Metal Ion Transport Transferrin Transport Regulation Of Bone Resorption Regulation Of Bone Remodeling Osteoclast Differentiation Cellular Response To Drug Cation Transport Response To Cadmium Ion Retina Homeostasis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Tissue Remodeling T Cell Differentiation In Thymus Regulation Of Defense Response To Virus Positive Regulation Of T Cell Mediated Cytotoxicity Vesicle-mediated Transport Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Myeloid Leukocyte Differentiation Interferon-gamma-mediated Signaling Pathway	Iron Ion Transport Cellular Iron Ion Homeostasis Iron Ion Homeostasis Transition Metal Ion Homeostasis Cellular Response To Iron Ion Starvation Multicellular Organismal Homeostasis Spongiotrophoblast Differentiation Iron Ion Import Into Cell Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Branching Involved In Labyrinthine Layer Morphogenesis Cellular Chemical Homeostasis Ion Homeostasis Iron Ion Import Spongiotrophoblast Layer Development Multicellular Organismal Iron Ion Homeostasis Cellular Homeostasis Trophoblast Giant Cell Differentiation Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of JAK-STAT Cascade Labyrinthine Layer Morphogenesis Growth Hormone Receptor Signaling Pathway Response To Stress Cellular Response To Growth Hormone Stimulus Embryonic Placenta Morphogenesis Metal Ion Transport Chemical Homeostasis Regulation Of Immune Response Transferrin Transport Cell Differentiation Involved In Embryonic Placenta Development Placenta Blood Vessel Development Negative Regulation Of Insulin Receptor Signaling Pathway Response To Growth Hormone Regulation Of Type I Interferon-mediated Signaling Pathway Hormone Biosynthetic Process JAK-STAT Cascade Cation Transport Labyrinthine Layer Development Retina Homeostasis Regulation Of Insulin Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Platelet Degranulation Reproductive Process Homeostatic Process Regulation Of Cellular Response To Insulin Stimulus
Tagcloud ?		25th 4th 75th alt aminotransferase ast bmi c282y crp dbp fasts hispanic homa homozygosity homozygotes lymphocytes missing overnight percentiles postscreening pressures quartile quartiles saturation sbp sf transferrin ts whites	arrays chemotaxis complement congenital count counts cxcr2 exome frameshift genotyped hbb hematocrit hematological hematopoiesis hemoglobin identifying missense neutropenia pedigree platelet resequencing separate sh2b3 splice traits tubb1 val617phe variants wbc
Tagcloud (Difference) ?		25th 4th 75th alt aminotransferase ast bmi c282y crp dbp fasts hispanic homa homozygosity homozygotes lymphocytes missing overnight percentiles postscreening pressures quartile quartiles saturation sbp sf transferrin ts whites	arrays chemotaxis complement congenital count counts cxcr2 exome frameshift genotyped hbb hematocrit hematological hematopoiesis hemoglobin identifying missense neutropenia pedigree platelet resequencing separate sh2b3 splice traits tubb1 val617phe variants wbc
Tagcloud (Intersection) ?