HFE and TFRC

Number of citations of the paper that reports this interaction (PMID 9465039)
99

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		HFE	TFRC
Gene Name		hemochromatosis	transferrin receptor
Image
Gene Ontology Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle MHC Class I Protein Complex Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome	Extracellular Region Extracellular Space Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Membrane-bounded Vesicle Vesicle Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Antigen Binding Receptor Binding Protein Binding Peptide Antigen Binding	Double-stranded RNA Binding Transferrin Receptor Activity Protein Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Complex Assembly Cellular Iron Ion Homeostasis Immune Response Female Pregnancy Cellular Response To Iron Ion Starvation Antigen Processing And Presentation Hormone Biosynthetic Process Multicellular Organismal Iron Ion Homeostasis Iron Ion Import Into Cell	Regulation Of Cell Growth Cellular Iron Ion Homeostasis Receptor-mediated Endocytosis Viral Process Osteoclast Differentiation Transferrin Transport Cellular Response To Drug Regulation Of Cell Proliferation Positive Regulation Of Bone Resorption Transmembrane Transport Iron Ion Import
Pathways			Iron uptake and transport Golgi Associated Vesicle Biogenesis Transferrin endocytosis and recycling trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Blood pressure ( 21909110) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 20686565) Diastolic blood pressure ( 21909115) Glycated hemoglobin levels ( 20858683) Hematocrit ( 19862010) Hematological parameters ( 19820697) Hematology traits ( 23263863 19853236) Hemoglobin ( 19820698 19862010) Hepcidin levels ( 21785125) Hypertension ( 21909115) Iron levels ( 21208937) Iron status biomarkers ( 21483845 21149283 19820699 19084217) LDL cholesterol ( 20686565) Mean corpuscular hemoglobin ( 23263863) Mean corpuscular volume ( 20139978 19862010) Red blood cell traits ( 23446634 20927387 23222517) Systolic blood pressure ( 21909115)	Mean corpuscular hemoglobin ( 20139978 19862010) Mean corpuscular volume ( 20139978 19862010) Pancreatic cancer ( 22158540) Red blood cell traits ( 23222517)
Protein-Protein Interactions		3 interactors: B2M TFR2 TFRC	11 interactors: ACAP1 B4GALT1 CD247 CD4 GABARAP HFE RAB5B RAB8A RANBP9 SGTA TF
Entrez ID		3077	7037
HPRD ID		01993	01812
Ensembl ID		ENSG00000010704	ENSG00000072274
Uniprot IDs		Q30201 Q6B0J5	A8K6Q8 P02786
PDB IDs		1A6Z 1C42 1DE4	1CX8 1DE4 1SUV 2NSU 3KAS 3S9L 3S9M 3S9N
Enriched GO Terms of Interacting Partners?		Iron Ion Homeostasis Transition Metal Ion Homeostasis Metal Ion Homeostasis Ion Homeostasis Iron Ion Transport Cellular Iron Ion Homeostasis Chemical Homeostasis Homeostatic Process Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Leukocyte Differentiation Receptor-mediated Endocytosis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To Drug Cellular Chemical Homeostasis Viral Process Iron Ion Import Positive Regulation Of Bone Resorption Hemopoiesis Endocytosis Protein Refolding Cellular Homeostasis Immune System Development Regulation Of Defense Response To Virus By Virus Positive Regulation Of Tissue Remodeling Metal Ion Transport Transferrin Transport Regulation Of Bone Resorption Regulation Of Bone Remodeling Osteoclast Differentiation Cellular Response To Drug Cation Transport Response To Cadmium Ion Retina Homeostasis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Tissue Remodeling T Cell Differentiation In Thymus Regulation Of Defense Response To Virus Positive Regulation Of T Cell Mediated Cytotoxicity Vesicle-mediated Transport Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Myeloid Leukocyte Differentiation Interferon-gamma-mediated Signaling Pathway	Protein Localization Protein Transport Establishment Of Protein Localization Regulation Of Defense Response To Virus By Virus Cellular Protein Localization Cellular Localization Transport Rab Protein Signal Transduction Cellular Response To Iron Ion Starvation Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation T Cell Costimulation Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Iron Ion Transport Regulation Of Defense Response To Virus Cellular Iron Ion Homeostasis T Cell Receptor Signaling Pathway Establishment Of Localization In Cell Iron Ion Homeostasis Lactose Biosynthetic Process Golgi Vesicle Fusion To Target Membrane Membrane Fusion Viral Process Immune System Process Response To Stimulus Antigen Receptor-mediated Signaling Pathway Cellular Response To Starvation Transition Metal Ion Homeostasis Response To Stress Regulation Of Exocytosis Disaccharide Metabolic Process Positive Regulation Of Immune Response Cellular Response To Nutrient Levels Response To Starvation Iron Ion Import Into Cell Vesicle-mediated Transport Penetration Of Zona Pellucida Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Plasma Membrane To Endosome Transport Intracellular Transport Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of T Cell Activation Cellular Response To Extracellular Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Ras Protein Signal Transduction Multicellular Organismal Homeostasis Regulation Of Acrosome Reaction Positive Regulation Of Cell-cell Adhesion Cell Communication
Tagcloud ?		25th 4th 75th alt aminotransferase ast bmi c282y crp dbp fasts hispanic homa homozygosity homozygotes lymphocytes missing overnight percentiles postscreening pressures quartile quartiles saturation sbp sf transferrin ts whites	actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately stmn1 taqman top2a tubb3 tyms vegfr2
Tagcloud (Difference) ?		25th 4th 75th alt aminotransferase ast bmi c282y crp dbp fasts hispanic homa homozygosity homozygotes lymphocytes missing overnight percentiles postscreening pressures quartile quartiles saturation sbp sf transferrin ts whites	actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately stmn1 taqman top2a tubb3 tyms vegfr2
Tagcloud (Intersection) ?