HFE and B2M

Number of citations of the paper that reports this interaction (PMID 10791995)
40

Data Source:
HPRD (in vitro)

		HFE	B2M
Gene Name		hemochromatosis	beta-2-microglobulin
Image
Gene Ontology Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle MHC Class I Protein Complex Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Focal Adhesion External Side Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Early Endosome Lumen MHC Class I Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Antigen Binding Receptor Binding Protein Binding Peptide Antigen Binding	Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Complex Assembly Cellular Iron Ion Homeostasis Immune Response Female Pregnancy Cellular Response To Iron Ion Starvation Antigen Processing And Presentation Hormone Biosynthetic Process Multicellular Organismal Iron Ion Homeostasis Iron Ion Import Into Cell	Retina Homeostasis Positive Regulation Of T Cell Mediated Cytotoxicity Response To Molecule Of Bacterial Origin Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Viral Process Cytokine-mediated Signaling Pathway T Cell Differentiation In Thymus Protein Refolding Response To Drug Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Response To Cadmium Ion Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response Iron Ion Homeostasis Interferon-gamma-mediated Signaling Pathway
Pathways			DAP12 interactions Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Interferon Signaling The role of Nef in HIV-1 replication and disease pathogenesis Cytokine Signaling in Immune system Nef mediated downregulation of MHC class I complex cell surface expression Antigen Presentation: Folding, assembly and peptide loading of class I MHC Interferon gamma signaling Amyloids DAP12 signaling Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen processing-Cross presentation ER-Phagosome pathway Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Blood pressure ( 21909110) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 20686565) Diastolic blood pressure ( 21909115) Glycated hemoglobin levels ( 20858683) Hematocrit ( 19862010) Hematological parameters ( 19820697) Hematology traits ( 23263863 19853236) Hemoglobin ( 19820698 19862010) Hepcidin levels ( 21785125) Hypertension ( 21909115) Iron levels ( 21208937) Iron status biomarkers ( 21483845 21149283 19820699 19084217) LDL cholesterol ( 20686565) Mean corpuscular hemoglobin ( 23263863) Mean corpuscular volume ( 20139978 19862010) Red blood cell traits ( 23446634 20927387 23222517) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		3 interactors: B2M TFR2 TFRC	20 interactors: A2M BAG6 CALR CD1A CD1B CD1D CD1E CD8A CRYAB FCGRT GRB2 HFE HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G LILRB1 PRSS23
Entrez ID		3077	567
HPRD ID		01993	00189
Ensembl ID		ENSG00000010704
Uniprot IDs		Q30201 Q6B0J5	F5H6I0 P61769
PDB IDs		1A6Z 1C42 1DE4	1A1M 1A1N 1A1O 1A6Z 1A9B 1A9E 1AGB 1AGC 1AGD 1AGE 1AGF 1AKJ 1AO7 1B0G 1B0R 1BD2 1C16 1CE6 1CG9 1DE4 1DUY 1DUZ 1E27 1E28 1EEY 1EEZ 1EFX 1EXU 1GZP 1GZQ 1HHG 1HHH 1HHI 1HHJ 1HHK 1HLA 1HSA 1HSB 1I1F 1I1Y 1I4F 1I7R 1I7T 1I7U 1IM3 1IM9 1JF1 1JGD 1JGE 1JHT 1JNJ 1K5N 1KPR 1KTL 1LDS 1LP9 1M05 1M6O 1MHE 1MI5 1N2R 1OF2 1OGA 1OGT 1ONQ 1P7Q 1PY4 1Q94 1QEW 1QLF 1QQD 1QR1 1QRN 1QSE 1QSF 1QVO 1R3H 1S8D 1S9W 1S9X 1S9Y 1SYS 1SYV 1T1W 1T1X 1T1Y 1T1Z 1T20 1T21 1T22 1TMC 1TVB 1TVH 1UQS 1UR7 1UXS 1UXW 1VGK 1W0V 1W0W 1W72 1X7Q 1XH3 1XR8 1XR9 1XZ0 1YDP 1YPZ 1ZHK 1ZHL 1ZS8 1ZSD 1ZT4 1ZVS 2A83 2AK4 2AV1 2AV7 2AXF 2AXG 2BCK 2BNQ 2BNR 2BSR 2BSS 2BST 2BVO 2BVP 2BVQ 2C7U 2CII 2CIK 2CLR 2D31 2D4D 2D4F 2DYP 2E8D 2ESV 2F53 2F54 2F74 2F8O 2FYY 2FZ3 2GIT 2GJ6 2GT9 2GTW 2GTZ 2GUO 2H26 2H6P 2HJK 2HJL 2HLA 2HN7 2J8U 2JCC 2NW3 2NX5 2P5E 2P5W 2PO6 2PYE 2RFX 2UWE 2V2W 2V2X 2VB5 2VLJ 2VLK 2VLL 2VLR 2X4N 2X4O 2X4P 2X4Q 2X4R 2X4S 2X4T 2X4U 2X70 2X89 2XKS 2XKU 2XPG 2YPK 2YPL 2YXF 2Z9T 3AM8 3B3I 3B6S 3BGM 3BH8 3BH9 3BHB 3BO8 3BP4 3BP7 3BVN 3BW9 3BWA 3BXN 3BZE 3BZF 3C9N 3CDG 3CII 3CIQ 3CZF 3D18 3D25 3D2U 3D39 3D3V 3DBX 3DHJ 3DHM 3DTX 3DX6 3DX7 3DX8 3DXA 3EKC 3FFC 3FQN 3FQR 3FQT 3FQU 3FQW 3FQX 3FT2 3FT3 3FT4 3GIV 3GJF 3GSN 3GSO 3GSQ 3GSR 3GSU 3GSV 3GSW 3GSX 3H7B 3H9H 3H9S 3HAE 3HCV 3HG1 3HLA 3HPJ 3HUJ 3I6G 3I6K 3I6L 3IB4 3IXA 3JTS 3KLA 3KPL 3KPM 3KPN 3KPO 3KPP 3KPQ 3KPR 3KPS 3KWW 3KXF 3KYN 3KYO 3L3D 3L3G 3L3I 3L3J 3L3K 3LKN 3LKO 3LKP 3LKQ 3LKR 3LKS 3LN4 3LN5 3LOW 3LOZ 3LV3 3M17 3M1B 3MGO 3MGT 3MR9 3MRB 3MRC 3MRD 3MRE 3MRF 3MRG 3MRH 3MRI 3MRJ 3MRK 3MRL 3MRM 3MRN 3MRO 3MRP 3MRQ 3MRR 3MV7 3MV8 3MV9 3MYJ 3MYZ 3MZT 3NA4 3NFN 3O3A 3O3B 3O3D 3O3E 3O4L 3OV6 3OX8 3OXR 3OXS 3PWJ 3PWL 3PWN 3PWP 3QDA 3QDG 3QDJ 3QDM 3QEQ 3QFD 3QFJ 3QZW 3REW 3RL1 3RL2 3RWJ 3S6C 3SDX 3SJV 3SKM 3SKO 3SPV 3T8X 3TID 3TIE 3TLR 3TM6 3TO2 3TZV 3U0P 3UPR 3UTQ 3UTS 3UTT 3V5D 3V5H 3V5K 3VCL 3VFM 3VFN 3VFO 3VFP 3VFR 3VFS 3VFT 3VFU 3VFV 3VFW 3VH8 3VRI 3VRJ 3VWJ 3VWK 3W39 4E0K 4E0L 4E5X 4EN3 4EUP 4EUQ 4F7M 4F7P 4F7T 4FTV 4FXL 4G8G 4G8I 4G9D 4G9F 4GKN 4GKS 4GUP 4HKJ 4HX1 4I48 4I4W 4JFD 4JFE 4JFF 4JFO 4JFP 4JFQ 4JQV 4JQX 4JRX 4JRY 4K7F 4KDT 4L4T 4L4V 4LCW
Enriched GO Terms of Interacting Partners?		Iron Ion Homeostasis Transition Metal Ion Homeostasis Metal Ion Homeostasis Ion Homeostasis Iron Ion Transport Cellular Iron Ion Homeostasis Chemical Homeostasis Homeostatic Process Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Leukocyte Differentiation Receptor-mediated Endocytosis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To Drug Cellular Chemical Homeostasis Viral Process Iron Ion Import Positive Regulation Of Bone Resorption Hemopoiesis Endocytosis Protein Refolding Cellular Homeostasis Immune System Development Regulation Of Defense Response To Virus By Virus Positive Regulation Of Tissue Remodeling Metal Ion Transport Transferrin Transport Regulation Of Bone Resorption Regulation Of Bone Remodeling Osteoclast Differentiation Cellular Response To Drug Cation Transport Response To Cadmium Ion Retina Homeostasis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Tissue Remodeling T Cell Differentiation In Thymus Regulation Of Defense Response To Virus Positive Regulation Of T Cell Mediated Cytotoxicity Vesicle-mediated Transport Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Myeloid Leukocyte Differentiation Interferon-gamma-mediated Signaling Pathway	Antigen Processing And Presentation Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Immune Response Positive Regulation Of Leukocyte Mediated Cytotoxicity Immune System Process Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Immune Response Regulation Of Immune System Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Innate Immune Response Cellular Response To Interferon-gamma Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity Response To Interferon-gamma Response To Stress Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Response To Stimulus Defense Response Regulation Of Dendritic Cell Differentiation Regulation Of Innate Immune Response Negative Regulation Of Immune Response Innate Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Cytokine-mediated Signaling Pathway Positive Regulation Of T Cell Activation Detection Of Bacterium Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Detection Of Biotic Stimulus
Tagcloud ?		25th 4th 75th alt aminotransferase ast bmi c282y crp dbp fasts hispanic homa homozygosity homozygotes lymphocytes missing overnight percentiles postscreening pressures quartile quartiles saturation sbp sf transferrin ts whites	a1m abnormality acetyl albumin albuminuria apparently competition excretion fractional gfr glomerular glucosaminidase histologically imply lmw microglobulin nag necessarily nephritic nephritis nephrotic proteinuria rbp reabsorption retinol ssns steroid tubular up1
Tagcloud (Difference) ?		25th 4th 75th alt aminotransferase ast bmi c282y crp dbp fasts hispanic homa homozygosity homozygotes lymphocytes missing overnight percentiles postscreening pressures quartile quartiles saturation sbp sf transferrin ts whites	a1m abnormality acetyl albumin albuminuria apparently competition excretion fractional gfr glomerular glucosaminidase histologically imply lmw microglobulin nag necessarily nephritic nephritis nephrotic proteinuria rbp reabsorption retinol ssns steroid tubular up1
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