HDLBP and ADAR

Number of citations: 0 (PubMedID 15723802)
Data Source: HPRD (in vitro)

		HDLBP	ADAR
Name		high density lipoprotein binding protein	adenosine deaminase RNA specific
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane High-density Lipoprotein Particle	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Nuclear Lumen Supraspliceosomal Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Lipid Binding Cadherin Binding	DNA Binding RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity Adenosine Deaminase Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Steroid Metabolic Process Cholesterol Metabolic Process	Osteoblast Differentiation Hematopoietic Progenitor Cell Differentiation Immune System Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Adenosine To Inosine Editing RNA Processing MRNA Processing Protein Import Into Nucleus Protein Export From Nucleus Apoptotic Process Response To Virus Base Conversion Or Substitution Editing Erythrocyte Differentiation Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing MiRNA Processing Response To Interferon-alpha Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Definitive Hemopoiesis Negative Regulation Of Type I Interferon-mediated Signaling Pathway Hematopoietic Stem Cell Homeostasis RISC Complex Assembly Hepatocyte Apoptotic Process Cellular Response To Virus Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Hepatocyte Apoptotic Process
Pathways		HDL clearance	C6 deamination of adenosine Formation of editosomes by ADAR proteins Interferon alpha/beta signaling PKR-mediated signaling
Diseases		None	Dyschromatosis symmetrica hereditaria
GWAS		Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Fibrinogen levels ( 26561523 28107422 ) HDL cholesterol levels ( 32203549 ) Intraocular pressure ( 29617998 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Prostate cancer ( 23535732 ) Serum alkaline phosphatase levels ( 33547301 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 )	Apolipoprotein A1 levels ( 32203549 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Interleukin-6 levels ( 33517400 ) Lung cancer ( 28604730 ) Prostate cancer ( 23535732 ) Squamous cell lung carcinoma ( 28604730 )
Interacting Genes		18 interacting genes: ADAR CDC42 CEBPA DHX9 ERBB2 ESR1 FILNC1 HMGB1 HMGB2 HSPB1 NEIL3 PLXNB2 RNF10 SMAD4 SOS1 SUMO2 TENT5A XPOT	10 interacting genes: CEBPA ERG HDLBP LINC00624 PTEN SMURF2 TGM2 UBE2I USP7 XPO1
Entrez ID		3069	103
HPRD ID		00813	07528
Ensembl ID		ENSG00000115677	ENSG00000160710
Uniprot IDs		A0A024R4E5 B2R5V9 Q00341	A0AAQ5BGH8 P55265
PDB IDs		1VIG 1VIH 2CTE 2CTF 2CTJ 2CTK 2CTL 2CTM	1QBJ 1QGP 1XMK 2ACJ 2GXB 2L54 2MDR 3F21 3F22 3F23 3IRQ 3IRR 5ZU1 5ZUO 5ZUP 7C0I 7ZJ1 7ZLQ 8GBC 8GBD
GO Terms Enriched among Interactors		Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Regulation Of Cell Population Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Single-stranded DNA Binding Regulation Of Developmental Process Transcription Cis-regulatory Region Binding Regulation Of Cell Differentiation Double-stranded DNA Binding Positive Regulation Of Interferon-beta Production Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Supercoiled DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of RNA Metabolic Process DNA Geometric Change Bubble DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of Interferon-beta Production Positive Regulation Of Viral Process Negative Regulation Of RNA Metabolic Process Damaged DNA Binding RISC Complex Assembly DNA Topological Change Positive Regulation Of Epithelial Cell Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Double-stranded RNA Binding Response To Stress RNA Binding Regulation Of Protein Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Hemopoiesis Cell Population Proliferation RAGE Receptor Binding Regulation Of Innate Immune Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Stabilization Protein-containing Complex	Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Membrane Assembly Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity SUMO Conjugating Enzyme Activity Regulation Of RNA Metabolic Process Nucleus Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Response To Vitamin B2 C/EBP Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Protein Deamination Cellular Response To Triglyceride Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Cellular Response To Serotonin RING-like Zinc Finger Domain Binding Symbiont-mediated Disruption Of Host Cell PML Body Sterol Metabolic Process Nucleoplasm Cholesterol Metabolic Process Negative Regulation Of Metabolic Process White Fat Cell Proliferation Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells SUMO Ligase Complex HLH Domain Binding Response To Triglyceride