HBE1 and HBM

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		HBE1	HBM
Description		hemoglobin subunit epsilon 1	hemoglobin subunit mu
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Blood Microparticle	Hemoglobin Complex Haptoglobin-hemoglobin Complex
	Molecular Function	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Hemoglobin Alpha Binding Metal Ion Binding	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Metal Ion Binding
	Biological Process	Carbon Dioxide Transport Oxygen Transport Erythrocyte Development	Oxygen Transport Erythrocyte Development
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Beta thalassemia/hemoglobin E disease ( 20183929) Hematology traits ( 23263863) Hemoglobin ( 28548082) Hemoglobin levels ( 26366553) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 28453575 23263863) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Body mass index ( 26426971) Glycated hemoglobin levels ( 31213470) Hemoglobin ( 32888494) Hemoglobin A1c levels ( 31217584) Hemoglobin levels ( 26366553) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 28453575 27863252 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		5 interacting genes: HBA1 HBA2 HBM HBQ1 HBZ	6 interacting genes: HBB HBD HBE1 HBG2 HBZ VIRMA
Entrez ID		3046	3042
HPRD ID		00788
Ensembl ID		ENSG00000213931	ENSG00000206177
Uniprot IDs		D9YZU7 P02100	Q6B0K9
PDB IDs		1A9W
Enriched GO Terms of Interacting Partners?		Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Oxygen Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Heme Binding Hemopoiesis Carbon Dioxide Transport Iron Ion Binding One-carbon Compound Transport Haptoglobin Binding Nitric Oxide Transport Cell Development Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Peroxidase Activity Hydrogen Peroxide Metabolic Process G Protein-coupled Receptor Binding Cellular Oxidant Detoxification Telomere Tethering At Nuclear Periphery Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Cellular Developmental Process Blood Microparticle Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Response To Reactive Oxygen Species Nuclear Pore Cytoplasmic Filaments Metal Ion Binding Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Telomere Localization Nuclear Pore Outer Ring Nuclear Pore Complex Assembly Nuclear Inclusion Body Nuclear Pore Nuclear Basket Nuclear Pore Organization Nuclear Periphery Response To Oxidative Stress Erythrocyte Maturation Pore Complex Assembly Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Developmental Process Peptide Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Inflammatory Response Positive Regulation Of RNA Splicing	Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Carbon Dioxide Transport Oxygen Transport Hemoglobin Alpha Binding One-carbon Compound Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Heme Binding Hemopoiesis Blood Microparticle Cell Development Cellular Developmental Process Haptoglobin Binding Nitric Oxide Transport Hemoglobin Binding Metal Ion Binding RNA N6-methyladenosine Methyltransferase Complex Hydrogen Peroxide Catabolic Process Endocytic Vesicle Lumen Erythrocyte Maturation Peroxidase Activity Hydrogen Peroxide Metabolic Process Developmental Process
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