HBE1

Description		hemoglobin subunit epsilon 1
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GO Annotations	Cellular Component	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Blood Microparticle
	Molecular Function	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Hemoglobin Alpha Binding Metal Ion Binding
	Biological Process	Carbon Dioxide Transport Oxygen Transport Erythrocyte Development
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Beta thalassemia/hemoglobin E disease ( 20183929) Hematology traits ( 23263863) Hemoglobin ( 28548082) Hemoglobin levels ( 26366553) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 28453575 23263863) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Novel Interacting Genes		1 novel interacting genes: NUP98
Interacting Genes		5 interacting genes: HBA1 HBA2 HBM HBQ1 HBZ
Entrez ID		3046
HPRD ID		00788
Ensembl ID		ENSG00000213931
Uniprot IDs		D9YZU7 P02100
PDB IDs		1A9W
Enriched GO Terms of Interacting Partners?		Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Oxygen Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Heme Binding Hemopoiesis Carbon Dioxide Transport Iron Ion Binding One-carbon Compound Transport Haptoglobin Binding Nitric Oxide Transport Cell Development Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Peroxidase Activity Hydrogen Peroxide Metabolic Process G Protein-coupled Receptor Binding Cellular Oxidant Detoxification Telomere Tethering At Nuclear Periphery Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Cellular Developmental Process Blood Microparticle Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Response To Reactive Oxygen Species Nuclear Pore Cytoplasmic Filaments Metal Ion Binding Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Telomere Localization Nuclear Pore Outer Ring Nuclear Pore Complex Assembly Nuclear Inclusion Body Nuclear Pore Nuclear Basket Nuclear Pore Organization Nuclear Periphery Response To Oxidative Stress Erythrocyte Maturation Pore Complex Assembly Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Developmental Process Peptide Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Inflammatory Response Positive Regulation Of RNA Splicing
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