HBA1 and ATP6AP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HBA1	ATP6AP1
Description		hemoglobin subunit alpha 1	ATPase H+ transporting accessory protein 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Hemoglobin Complex Membrane Haptoglobin-hemoglobin Complex Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle	Golgi Membrane Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Endomembrane System Membrane Proton-transporting Two-sector ATPase Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Proton-transporting V-type ATPase Complex Synapse Extracellular Exosome Bounding Membrane Of Organelle
	Molecular Function	G Protein-coupled Receptor Binding Peroxidase Activity Oxygen Carrier Activity Iron Ion Binding Protein Binding Oxygen Binding Heme Binding Haptoglobin Binding Metal Ion Binding	ATPase Activator Activity Protein Binding Small GTPase Binding Transporter Activator Activity
	Biological Process	Inflammatory Response Carbon Dioxide Transport Oxygen Transport Nitric Oxide Transport Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Erythrocyte Development Cellular Oxidant Detoxification	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Cellular PH Osteoclast Development Cellular Response To Increased Oxygen Levels Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Endosome To Plasma Membrane Protein Transport Proton Transmembrane Transport
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Scavenging of heme from plasma Cytoprotection by HMOX1 Heme signaling Heme assimilation	Insulin receptor recycling RHOA GTPase cycle Transferrin endocytosis and recycling Ion channel transport
Drugs		Iron Dextran Iron Zinc 4-Carboxycinnamic Acid Pentaerythritol tetranitrate 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine Sebacic acid 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID 2,6-dicarboxynaphthalene Efaproxiral Trimesic acid Nitrous acid Copper Ferric pyrophosphate Sodium ferric gluconate complex Ferrous sulfate anhydrous Ferric pyrophosphate citrate Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Zinc chloride Zinc sulfate, unspecified form Voxelotor Ferric derisomaltose	Tiludronic acid
Diseases		Thalassemia; Alpha thalassemia; Beta thalassemia; Alpha thalassemia, X-linked (ATRX)
GWAS		Body mass index ( 26426971) Hemoglobin ( 32888494) Hemoglobin levels ( 26366553 32327693) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 20139978 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		19 interacting genes: ATP6AP1 CRYAB DAXX HBB HBD HBE1 HBG2 HBQ1 KRT31 KRT34 NAP1L1 NBPF19 NEIL3 NOTCH2NLA PTEN RNF181 SPINK7 UBE3A UCHL5	6 interacting genes: ANG ERBB2 HBA1 NR1I2 OGT RHOU
Entrez ID		3039	537
HPRD ID		00784	02184
Ensembl ID		ENSG00000206172	ENSG00000071553
Uniprot IDs		D1MGQ2 P69905	A0A384MQW4 Q15904
PDB IDs		1A00 1A01 1A0U 1A0Z 1A3N 1A3O 1A9W 1ABW 1ABY 1AJ9 1B86 1BAB 1BBB 1BIJ 1BUW 1BZ0 1BZ1 1BZZ 1C7B 1C7C 1C7D 1CLS 1CMY 1COH 1DKE 1DXT 1DXU 1DXV 1FDH 1FN3 1G9V 1GBU 1GBV 1GLI 1GZX 1HAB 1HAC 1HBA 1HBB 1HBS 1HCO 1HDB 1HGA 1HGB 1HGC 1HHO 1IRD 1J3Y 1J3Z 1J40 1J41 1J7S 1J7W 1J7Y 1JY7 1K0Y 1K1K 1KD2 1LFL 1LFQ 1LFT 1LFV 1LFY 1LFZ 1LJW 1M9P 1MKO 1NEJ 1NIH 1NQP 1O1I 1O1J 1O1K 1O1L 1O1M 1O1N 1O1O 1O1P 1QI8 1QSH 1QSI 1QXD 1QXE 1R1X 1R1Y 1RPS 1RQ3 1RQ4 1RQA 1RVW 1SDK 1SDL 1SHR 1SI4 1THB 1UIW 1VWT 1XXT 1XY0 1XYE 1XZ2 1XZ4 1XZ5 1XZ7 1XZU 1XZV 1Y01 1Y09 1Y0A 1Y0C 1Y0D 1Y0T 1Y0W 1Y22 1Y2Z 1Y31 1Y35 1Y45 1Y46 1Y4B 1Y4F 1Y4G 1Y4P 1Y4Q 1Y4R 1Y4V 1Y5F 1Y5J 1Y5K 1Y7C 1Y7D 1Y7G 1Y7Z 1Y83 1Y85 1Y8W 1YDZ 1YE0 1YE1 1YE2 1YEN 1YEO 1YEQ 1YEU 1YEV 1YFF 1YG5 1YGD 1YGF 1YH9 1YHE 1YHR 1YIE 1YIH 1YVQ 1YVT 1YZI 1Z8U 2D5Z 2D60 2DN1 2DN2 2DN3 2DXM 2H35 2HBC 2HBD 2HBE 2HBF 2HBS 2HCO 2HHB 2HHD 2HHE 2M6Z 2W6V 2W72 2YRS 3B75 3D17 3D7O 3DUT 3HHB 3HXN 3IA3 3IC0 3IC2 3KMF 3NL7 3NMM 3ODQ 3ONZ 3OO4 3OO5 3OVU 3P5Q 3QJB 3QJC 3QJD 3QJE 3R5I 3S48 3S65 3S66 3SZK 3WCP 3WHM 4FC3 4HHB 4IJ2 4L7Y 4M4A 4M4B 4MQC 4MQG 4MQH 4MQI 4MQJ 4MQK 4N7N 4N7O 4N7P 4N8T 4NI0 4NI1 4ROL 4ROM 4WJG 4X0L 4XS0 5E29 5E6E 5E83 5EE4 5HU6 5HY8 5JDO 5KDQ 5KSI 5KSJ 5NI1 5SW7 5U3I 5UCU 5UFJ 5URC 5VMM 5WOG 5WOH 5X2R 5X2S 5X2T 5X2U 6BB5 6BNR 6BWP 6BWU 6DI4 6HAL 6HBW 6HK2 6KA9 6KAE 6KAH 6KAI 6KAO 6KAP 6KAQ 6KAR 6KAS 6KAT 6KAU 6KAV 6KYE 6L5V 6L5W 6L5X 6L5Y 6LCW 6LCX 6NBC 6NBD 6NQ5 6TB2 6XD9 6XDT 6XE7 7AET 7AEU 7AEV 7CUE 7DY3 7DY4 7JJQ 7JXZ 7JY0 7JY1 7JY3 7K4M 7PCF 7PCH 7PCQ 7QU4 7UD7 7UD8 7UF6 7UF7 7UVB 7VDE 7XGY 8DOV 8EGI 8FDK 8FDL 8FDM 8FDN 8VYL 8WJ0 8WJ1 8WJ2 8WXW 8XMP 8XMQ 8XMW 9AV9 9AYZ 9BCJ 9FHB 9FMU 9FNO	6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Hemoglobin Alpha Binding Oxygen Transport Myeloid Cell Development Oxygen Binding Erythrocyte Development Carbon Dioxide Transport One-carbon Compound Transport Hemopoiesis Heme Binding Blood Microparticle Forebrain Morphogenesis Developmental Process Cell Development Androgen Receptor Signaling Pathway Cellular Developmental Process Structural Molecule Activity Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Ubiquitin-dependent Protein Catabolic Process Sperm Entry Positive Regulation Of Golgi Lumen Acidification MCM Complex Binding Intracellular PH Reduction Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Diamide Structural Constituent Of Skin Epidermis Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Proteasome Complex	Nucleobase-containing Compound Catabolic Process Sulfur Compound Transmembrane Transporter Activity Positive Regulation Of Lipid Biosynthetic Process Fatty-acyl-CoA Transport Very Long-chain Fatty-acyl-CoA Metabolic Process Organophosphate Ester Transmembrane Transporter Activity Very Long-chain Fatty-acyl-CoA Catabolic Process Amide Transmembrane Transporter Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity Nucleobase-containing Compound Transmembrane Transporter Activity Homeostatic Process ABC-type Fatty-acyl-CoA Transporter Activity Catabolic Process Cytosol Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of RNA Catabolic Process RNA Stabilization TRNA-specific Ribonuclease Activity Regulation Of Translation Cytoplasmic Stress Granule Membraneless Organelle Assembly Angiogenin-PRI Complex Negative Regulation Of Catabolic Process Regulation Of Protein Localization Translation Positive Regulation Of Establishment Of Protein Localization XPC Complex RNA Polymerase I Core Binding ERBB3:ERBB2 Complex Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Translation Haptoglobin Binding 5'-deoxynucleotidase Activity Adenosine Biosynthetic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Translational Initiation TOR Signaling Positive Regulation Of Translational Initiation TORC1 Signaling Protein O-acetylglucosaminyltransferase Activity Cellular Response To Rapamycin Regulation Of Translational Initiation Nucleoside Phosphate Catabolic Process Regulation Of Biological Quality Regulation Of Generation Of Precursor Metabolites And Energy Fatty-acyl-CoA Catabolic Process Long-chain Fatty Acid Import Into Peroxisome Cytoplasmic Translation
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