HBA1 and HBB

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (x-ray crystallography)
HPRD (two hybrid)

		HBA1	HBB
Gene Name		hemoglobin, alpha 1	hemoglobin, beta
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Hemoglobin Complex Membrane Cytosolic Small Ribosomal Subunit Haptoglobin-hemoglobin Complex Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle	Extracellular Region Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle
	Molecular Function	Peroxidase Activity Oxygen Transporter Activity Iron Ion Binding Protein Binding Oxygen Binding Heme Binding Haptoglobin Binding	Peroxidase Activity Oxygen Transporter Activity Iron Ion Binding Protein Binding Oxygen Binding Heme Binding Hemoglobin Binding Haptoglobin Binding
	Biological Process	Receptor-mediated Endocytosis Positive Regulation Of Cell Death Oxygen Transport Bicarbonate Transport Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Small Molecule Metabolic Process Protein Heterooligomerization Oxidation-reduction Process	Receptor-mediated Endocytosis Blood Coagulation Regulation Of Blood Pressure Positive Regulation Of Cell Death Oxygen Transport Bicarbonate Transport Nitric Oxide Transport Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Small Molecule Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Blood Vessel Size Protein Heterooligomerization Oxidation-reduction Process Renal Absorption Platelet Aggregation
Pathways		O2/CO2 exchange in erythrocytes Scavenging of heme from plasma Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide	O2/CO2 exchange in erythrocytes Scavenging of heme from plasma Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Factors involved in megakaryocyte development and platelet production
Drugs			Iron Dextran 4-Carboxycinnamic Acid Heme 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine SEBACIC ACID 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID 2,6-DICARBOXYNAPHTHALENE 2-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID 1,3,5-BENZENETRICARBOXYLIC ACID
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978)	F-cell distribution ( 17767159) Fetal hemoglobin levels ( 18245381) HbA2 levels ( 23043469) Hematology traits ( 23263863) Inflammatory biomarkers ( 22291609) Malaria ( 22895189 23717212 19465909) Mean corpuscular hemoglobin concentration ( 23263863)
Protein-Protein Interactions		9 interactors: ATP6AP1 CRYAB DAXX HBB NAP1L1 PTEN SPINK7 UBE3A UCHL5	9 interactors: HBA1 HBA2 HBG2 HBZ HP PABPC1 SELT UCHL5 UPF3B
Entrez ID		3039	3043
HPRD ID		00784	00786
Ensembl ID		ENSG00000206172	ENSG00000244734
Uniprot IDs		D1MGQ2 P69905	D9YZU5 P68871
PDB IDs		1A00 1A01 1A0U 1A0Z 1A3N 1A3O 1A9W 1ABW 1ABY 1AJ9 1B86 1BAB 1BBB 1BIJ 1BUW 1BZ0 1BZ1 1BZZ 1C7B 1C7C 1C7D 1CLS 1CMY 1COH 1DKE 1DXT 1DXU 1DXV 1FDH 1FN3 1G9V 1GBU 1GBV 1GLI 1GZX 1HAB 1HAC 1HBA 1HBB 1HBS 1HCO 1HDB 1HGA 1HGB 1HGC 1HHO 1IRD 1J3Y 1J3Z 1J40 1J41 1J7S 1J7W 1J7Y 1JY7 1K0Y 1K1K 1KD2 1LFL 1LFQ 1LFT 1LFV 1LFY 1LFZ 1LJW 1M9P 1MKO 1NEJ 1NIH 1NQP 1O1I 1O1J 1O1K 1O1L 1O1M 1O1N 1O1O 1O1P 1QI8 1QSH 1QSI 1QXD 1QXE 1R1X 1R1Y 1RPS 1RQ3 1RQ4 1RQA 1RVW 1SDK 1SDL 1SHR 1SI4 1THB 1UIW 1VWT 1XXT 1XY0 1XYE 1XZ2 1XZ4 1XZ5 1XZ7 1XZU 1XZV 1Y01 1Y09 1Y0A 1Y0C 1Y0D 1Y0T 1Y0W 1Y22 1Y2Z 1Y31 1Y35 1Y45 1Y46 1Y4B 1Y4F 1Y4G 1Y4P 1Y4Q 1Y4R 1Y4V 1Y5F 1Y5J 1Y5K 1Y7C 1Y7D 1Y7G 1Y7Z 1Y83 1Y85 1Y8W 1YDZ 1YE0 1YE1 1YE2 1YEN 1YEO 1YEQ 1YEU 1YEV 1YFF 1YG5 1YGD 1YGF 1YH9 1YHE 1YHR 1YIE 1YIH 1YVQ 1YVT 1YZI 1Z8U 2D5Z 2D60 2DN1 2DN2 2DN3 2DXM 2H35 2HBC 2HBD 2HBE 2HBF 2HBS 2HCO 2HHB 2HHD 2HHE 2M6Z 2W6V 2W72 2YRS 3B75 3D17 3D7O 3DUT 3HHB 3HXN 3IA3 3IC0 3IC2 3KMF 3NL7 3NMM 3ODQ 3ONZ 3OO4 3OO5 3OVU 3P5Q 3QJB 3QJC 3QJD 3QJE 3R5I 3S48 3S65 3S66 3SZK 3WCP 4FC3 4HHB 4L7Y 4MQC 4MQG 4MQH 4MQI 4MQJ 6HBW	1A00 1A01 1A0U 1A0Z 1A3N 1A3O 1ABW 1ABY 1AJ9 1B86 1BAB 1BBB 1BIJ 1BUW 1BZ0 1BZ1 1BZZ 1C7B 1C7C 1C7D 1CBL 1CBM 1CH4 1CLS 1CMY 1COH 1DKE 1DXT 1DXU 1DXV 1FN3 1G9V 1GBU 1GBV 1GLI 1GZX 1HAB 1HAC 1HBA 1HBB 1HBS 1HCO 1HDB 1HGA 1HGB 1HGC 1HHO 1IRD 1J3Y 1J3Z 1J40 1J41 1J7S 1J7W 1J7Y 1JY7 1K0Y 1K1K 1KD2 1LFL 1LFQ 1LFT 1LFV 1LFY 1LFZ 1LJW 1M9P 1MKO 1NEJ 1NIH 1NQP 1O1I 1O1J 1O1K 1O1L 1O1M 1O1N 1O1O 1O1P 1QI8 1QSH 1QSI 1QXD 1QXE 1R1X 1R1Y 1RPS 1RQ3 1RQ4 1RQA 1RVW 1SDK 1SDL 1THB 1UIW 1VWT 1XXT 1XY0 1XYE 1XZ2 1XZ4 1XZ5 1XZ7 1XZU 1XZV 1Y09 1Y0A 1Y0C 1Y0D 1Y0T 1Y0W 1Y22 1Y2Z 1Y31 1Y35 1Y45 1Y46 1Y4B 1Y4F 1Y4G 1Y4P 1Y4Q 1Y4R 1Y4V 1Y5F 1Y5J 1Y5K 1Y7C 1Y7D 1Y7G 1Y7Z 1Y83 1Y85 1Y8W 1YDZ 1YE0 1YE1 1YE2 1YEN 1YEO 1YEQ 1YEU 1YEV 1YFF 1YG5 1YGD 1YGF 1YH9 1YHE 1YHR 1YIE 1YIH 1YVQ 1YVT 1YZI 2D5Z 2D60 2DN1 2DN2 2DN3 2DXM 2H35 2HBC 2HBD 2HBE 2HBF 2HBS 2HCO 2HHB 2HHD 2HHE 2M6Z 2W6V 2W72 2YRS 3B75 3D17 3D7O 3DUT 3HHB 3HXN 3IC0 3IC2 3KMF 3NL7 3NMM 3ODQ 3ONZ 3OO4 3OO5 3P5Q 3QJB 3QJC 3QJD 3QJE 3R5I 3S65 3S66 3SZK 3W4U 3WCP 4FC3 4HHB 4L7Y 4MQC 4MQG 4MQH 6HBW
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Prostate Gland Growth Forebrain Morphogenesis Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Androgen Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Brain Morphogenesis Negative Regulation Of Peptidase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Cellular Component Assembly Prostate Gland Development Regulation Of Endopeptidase Activity Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Protein Catabolic Process Protein Complex Assembly Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Sperm Entry Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Response To Inorganic Substance Organ Growth Regulation Of Metabolic Process Nucleosome Assembly Activation Of APC-Cdc20 Complex Activity Postsynaptic Density Assembly Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Response To Estradiol Regulation Of Catalytic Activity Response To Hydrogen Peroxide Chromatin Assembly Nucleosome Organization Negative Regulation Of Dendritic Spine Morphogenesis Nitric Oxide Transport Chromatin Assembly Or Disassembly Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Death	Oxygen Transport Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Response To Reactive Oxygen Species Bicarbonate Transport Hydrogen Peroxide Metabolic Process Regulation Of Translation Catabolic Process Receptor-mediated Endocytosis Positive Regulation Of Translation Negative Regulation Of Hydrogen Peroxide Catabolic Process MRNA 3'-end Processing Transport Response To Oxidative Stress Posttranscriptional Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Response To Inorganic Substance RNA 3'-end Processing Reactive Oxygen Species Metabolic Process Protein Heterooligomerization Positive Regulation Of Cell Death Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Hydrogen Peroxide Metabolic Process Endocytosis MRNA Catabolic Process Insulin Secretion Involved In Cellular Response To Glucose Stimulus RNA Catabolic Process Selenocysteine Incorporation Cellular Macromolecule Catabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Response To Stress Erythrocyte Maturation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Protein Metabolic Process Regulation Of MRNA 3'-end Processing RNA Splicing Positive Regulation Of MRNA Catabolic Process Forebrain Morphogenesis Lateral Ventricle Development Negative Regulation Of Oxidoreductase Activity Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Stabilization MRNA Processing
Tagcloud ?		account alter auditory brainstem cerebrovascular cognitive derangement diabetics duration electrophysiological electrophysiologically evoked head infarcts lacunar latencies longer mellitus mri neither neuroradiologically niddm potentials regardless remaining scans taking v wave	alleles allelic coding divergence emphasize es gpi id inbred institute institutes ldr loci monitoring mpi mup necessity netherlands nominally pgm possibility purity routine scheme simultaneously strains sub substrains variation
Tagcloud (Difference) ?		account alter auditory brainstem cerebrovascular cognitive derangement diabetics duration electrophysiological electrophysiologically evoked head infarcts lacunar latencies longer mellitus mri neither neuroradiologically niddm potentials regardless remaining scans taking v wave	alleles allelic coding divergence emphasize es gpi id inbred institute institutes ldr loci monitoring mpi mup necessity netherlands nominally pgm possibility purity routine scheme simultaneously strains sub substrains variation
Tagcloud (Intersection) ?