HAS3 and PLP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HAS3	PLP1
Description		hyaluronan synthase 3	proteolipid protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endosome Early Endosome Golgi Apparatus Plasma Membrane Membrane Hyaluranon Cable	Plasma Membrane Membrane Myelin Sheath Synapse
	Molecular Function	Protein Binding Transferase Activity Glycosyltransferase Activity Identical Protein Binding Hyaluronan Synthase Activity	Structural Molecule Activity Protein Binding Structural Constituent Of Myelin Sheath Identical Protein Binding
	Biological Process	Polysaccharide Biosynthetic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Hyaluronan Biosynthetic Process Positive Regulation Of DNA-templated Transcription Extracellular Matrix Assembly Positive Regulation Of Hyaluranon Cable Assembly	Inflammatory Response Chemical Synaptic Transmission Axon Ensheathment Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Myelination Long-chain Fatty Acid Biosynthetic Process Axon Development
Pathways		Hyaluronan metabolism
Drugs
Diseases			Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)
GWAS		Attention deficit hyperactivity disorder ( 18821565) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653)
Interacting Genes		6 interacting genes: APOL3 C14orf180 CMTM7 LHFPL5 PLP1 SYNGR1	91 interacting genes: ADGRG3 AKT1 AQP10 AQP6 ARL13B BCL2L13 BIK CALN1 CALR CANX CD40 CD74 CDIPT CLDN2 CLDN20 CLEC2D CLN8 CREB3 CREB3L1 CYB5R3 CYBC1 DCT DYRK1A DYSF EDA2R ELOVL4 ERGIC3 FAM209A FCRL2 FFAR2 FKBP7 FNDC9 GAST GJA8 GPR42 GPR61 HAS3 HTR2C IER3IP1 IFITM3 ITGAV JAGN1 JPH1 KLRC1 LEPROTL1 LEUTX LHFPL5 LMNA MAG MBP MFF MGST3 MS4A3 MS4A4A MTIF3 MUC1 MYADM NRG1 PI16 PIGP PTPRN RELL2 RMDN3 RNF24 SLC10A6 SLC16A2 SLC18A1 SLC1A5 SLC26A6 SLC35E2A SLC35E3 SLC35H1 SLC41A3 SMIM3 SPNS3 STX1A STX4 SUSD3 TMEM106C TMEM14B TMEM182 TMEM242 TMEM243 TMEM254 TMEM31 TMEM45B TMEM52B TMEM97 TMPRSS2 UPK2 VAT1
Entrez ID		3038	5354
HPRD ID		03889	02321
Ensembl ID		ENSG00000103044	ENSG00000123560
Uniprot IDs		O00219 Q96RV2	A0A0S2Z4D4 A8K9L3 B4DI30 P60201
PDB IDs			2XPG
Enriched GO Terms of Interacting Partners?			Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Transmembrane Transport Negative Regulation Of Apoptotic Signaling Pathway Compact Myelin Antiporter Activity
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