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HADHA and CD74
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
HADHA
CD74
Gene Name
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
CD74 molecule, major histocompatibility complex, class II invariant chain
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex
Mitochondrial Nucleoid
Golgi Membrane
Intracellular
Lysosomal Membrane
Multivesicular Body
Vacuole
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Membrane
Integral Component Of Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Macrophage Migration Inhibitory Factor Receptor Complex
NOS2-CD74 Complex
MHC Class II Protein Complex
Lysosomal Lumen
Extracellular Vesicular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
Fatty-acyl-CoA Binding
3-hydroxyacyl-CoA Dehydrogenase Activity
Acetyl-CoA C-acetyltransferase Activity
Enoyl-CoA Hydratase Activity
Protein Binding
Long-chain-enoyl-CoA Hydratase Activity
Long-chain-3-hydroxyacyl-CoA Dehydrogenase Activity
Protein Complex Binding
NAD Binding
Beta-amyloid Binding
Cytokine Receptor Activity
Protein Binding
Cytokine Binding
MHC Class II Protein Complex Binding
Macrophage Migration Inhibitory Factor Binding
MHC Class II Protein Binding
MHC Class II Protein Binding, Via Antigen Binding Groove
Identical Protein Binding
Protein Binding Involved In Protein Folding
Nitric-oxide Synthase Binding
Biological Process
Fatty Acid Beta-oxidation
Phospholipid Metabolic Process
Response To Insulin
Cardiolipin Acyl-chain Remodeling
Response To Drug
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Glycerophospholipid Biosynthetic Process
Activation Of MAPK Activity
Prostaglandin Biosynthetic Process
Positive Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of Peptide Secretion
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Mature B Cell Apoptotic Process
Protein Complex Assembly
Intracellular Protein Transport
Defense Response
Signal Transduction
Cell Proliferation
Immunoglobulin Mediated Immune Response
Antigen Processing And Presentation Of Endogenous Antigen
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Positive Regulation Of B Cell Proliferation
Macrophage Migration Inhibitory Factor Signaling Pathway
Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
T Cell Selection
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Negative Regulation Of T Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Chaperone Mediated Protein Folding Requiring Cofactor
Positive Regulation Of Macrophage Cytokine Production
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways
Acyl chain remodeling of CL
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Mitochondrial Fatty Acid Beta-Oxidation
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Glycerophospholipid biosynthesis
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Beta oxidation of palmitoyl-CoA to myristoyl-CoA
Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
mitochondrial fatty acid beta-oxidation of saturated fatty acids
Beta oxidation of myristoyl-CoA to lauroyl-CoA
Phospholipid metabolism
MHC class II antigen presentation
Adaptive Immune System
Drugs
NADH
Diseases
GWAS
Protein-Protein Interactions
6 interactors:
ABCF2
ATXN2L
CD74
NR4A1
PIN1
YWHAQ
14 interactors:
APP
CD1D
CD44
CTSF
CTSL
HADHA
HLA-DMA
HLA-DMB
HLA-DPA1
HLA-DPB1
HLA-DQA1
HLA-DQB1
HLA-DRA
MIF
Entrez ID
3030
972
HPRD ID
02934
00825
Ensembl ID
ENSG00000084754
ENSG00000019582
Uniprot IDs
B4DRH6
E9KL44
P40939
P04233
PDB IDs
1A6A
1ICF
1IIE
1L3H
1MUJ
3PDO
3PGC
3PGD
3QXA
3QXD
4AEN
4AH2
Enriched GO Terms of Interacting Partners
?
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Antigen Processing And Presentation
Positive Regulation Of Homotypic Cell-cell Adhesion
Antigen Processing And Presentation Of Peptide Antigen
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Activation
Immune Response
Positive Regulation Of T Cell Activation
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Lymphocyte Activation
Positive Regulation Of Immune Response
Immune System Process
Regulation Of Cell Activation
Regulation Of T Cell Activation
Innate Immune Response
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Regulation Of Cell Adhesion
Interferon-gamma-mediated Signaling Pathway
Cellular Response To Interferon-gamma
Regulation Of Immune System Process
Defense Response
Response To Interferon-gamma
T Cell Costimulation
Peptide Antigen Assembly With MHC Class II Protein Complex
MHC Class II Protein Complex Assembly
T Cell Receptor Signaling Pathway
Positive Regulation Of Lymphocyte Proliferation
Positive Regulation Of Mononuclear Cell Proliferation
Antigen Receptor-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Immune Response-regulating Signaling Pathway
Positive Regulation Of T Cell Proliferation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cellular Response To Cytokine Stimulus
Regulation Of T Cell Proliferation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Response To Cytokine
Response To Organic Substance
Response To Stress
Response To Stimulus
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Cellular Response To Organic Substance
Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Cell Proliferation
Tagcloud
?
actionable
adenocarcinomas
akt1
alk
braf
capture
ccdc6
clip4
deemed
driver
fusions
g719a
genomic
introns
kif5b
map2k1
nccn
ngs
nras
pack
pik3ca
profiling
rearranged
ret
ros1
socs5
targetable
uniform
v600e
Tagcloud (Difference)
?
actionable
adenocarcinomas
akt1
alk
braf
capture
ccdc6
clip4
deemed
driver
fusions
g719a
genomic
introns
kif5b
map2k1
nccn
ngs
nras
pack
pik3ca
profiling
rearranged
ret
ros1
socs5
targetable
uniform
v600e
Tagcloud (Intersection)
?