HADHA

Description		hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Nucleoid
	Molecular Function	Catalytic Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Acetyl-CoA C-acetyltransferase Activity Enoyl-CoA Hydratase Activity Protein Binding Oxidoreductase Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Transferase Activity Lyase Activity 3-hydroxyacyl-CoA Dehydratase Activity Long-chain Fatty Acyl-CoA Hydrolase Activity NAD+ Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Response To Insulin Cardiolipin Acyl-chain Remodeling
Pathways		Acyl chain remodeling of CL Beta oxidation of myristoyl-CoA to lauroyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of palmitoyl-CoA to myristoyl-CoA Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Drugs		NADH
Diseases		Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP) Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS
Novel Interacting Genes		1 novel interacting genes: NCOA1
Interacting Genes		10 interacting genes: ABCF2 ATXN2L CD74 CEBPA HSD17B10 NR4A1 PIN1 PTEN UBC YWHAQ
Entrez ID		3030
HPRD ID		02934
Ensembl ID		ENSG00000084754
Uniprot IDs		E9KL44 P40939
PDB IDs		5ZQZ 5ZRV 6DV2
Enriched GO Terms of Interacting Partners?		MHC Class II Protein Binding, Via Antigen Binding Groove Positive Regulation Of RNA Biosynthetic Process NOS2-CD74 Complex Protein Stabilization Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cell Development Positive Regulation Of DNA-templated Transcription Regulation Of Macrophage Activation Transcription Regulator Complex Intracellular Signal Transduction RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ubiquitin Ligase Activator Activity Cis-trans Isomerase Activity Negative Regulation Of Synaptic Vesicle Clustering Reproductive Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Endocytic Vesicle Membrane Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Macrophage Migration Inhibitory Factor Binding Negative Regulation Of Cell Motility Protein-containing Complex Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Macrophage Migration Inhibitory Factor Receptor Complex RNA Metabolic Process Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Labyrinthine Layer Morphogenesis Negative Regulation Of Locomotion Regulation Of Protein Stability Regulation Of Protein Phosphorylation Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Cellular Component Assembly CHOP-C/EBP Complex
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