HADHA and ABCF2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HADHA	ABCF2
Description		hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	ATP binding cassette subfamily F member 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Nucleoid	Plasma Membrane Membrane
	Molecular Function	Catalytic Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Acetyl-CoA C-acetyltransferase Activity Enoyl-CoA Hydratase Activity Protein Binding Oxidoreductase Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Transferase Activity Lyase Activity 3-hydroxyacyl-CoA Dehydratase Activity Long-chain Fatty Acyl-CoA Hydrolase Activity NAD+ Binding	Nucleotide Binding ATP Binding ATP Hydrolysis Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Response To Insulin Cardiolipin Acyl-chain Remodeling
Pathways		Acyl chain remodeling of CL Beta oxidation of myristoyl-CoA to lauroyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of palmitoyl-CoA to myristoyl-CoA Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA	NFE2L2 regulating MDR associated enzymes
Drugs		NADH
Diseases		Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP) Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS			Eyebrow thickness ( 26926045) Femoral neck bone mineral density ( 22504420) Height ( 31562340) IgG glycosylation ( 23382691) IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		10 interacting genes: ABCF2 ATXN2L CD74 CEBPA HSD17B10 NR4A1 PIN1 PTEN UBC YWHAQ	4 interacting genes: ANKRD28 HADHA PTEN UPF2
Entrez ID		3030	10061
HPRD ID		02934	12403
Ensembl ID		ENSG00000084754	ENSG00000033050
Uniprot IDs		E9KL44 P40939	A0A090N7X1 Q9UG63
PDB IDs		5ZQZ 5ZRV 6DV2
Enriched GO Terms of Interacting Partners?		MHC Class II Protein Binding, Via Antigen Binding Groove Positive Regulation Of RNA Biosynthetic Process NOS2-CD74 Complex Protein Stabilization Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cell Development Positive Regulation Of DNA-templated Transcription Regulation Of Macrophage Activation Transcription Regulator Complex Intracellular Signal Transduction RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ubiquitin Ligase Activator Activity Cis-trans Isomerase Activity Negative Regulation Of Synaptic Vesicle Clustering Reproductive Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Endocytic Vesicle Membrane Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Macrophage Migration Inhibitory Factor Binding Negative Regulation Of Cell Motility Protein-containing Complex Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Macrophage Migration Inhibitory Factor Receptor Complex RNA Metabolic Process Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Labyrinthine Layer Morphogenesis Negative Regulation Of Locomotion Regulation Of Protein Stability Regulation Of Protein Phosphorylation Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Cellular Component Assembly CHOP-C/EBP Complex	Regulation Of Cell-substrate Junction Organization Regulation Of Focal Adhesion Assembly Lipid Modification Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Regulation Of Cell-matrix Adhesion Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Acetyl-CoA C-acetyltransferase Activity Glycerophospholipid Metabolic Process (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Cardiolipin Acyl-chain Remodeling Regulation Of Cell Junction Assembly Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Regulation Of Synaptic Vesicle Clustering Regulation Of Cell-substrate Adhesion Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Phospholipid Metabolic Process Cardiolipin Metabolic Process Glycerolipid Metabolic Process Enoyl-CoA Hydratase Activity 3-hydroxyacyl-CoA Dehydratase Activity Negative Regulation Of Peptidyl-serine Phosphorylation Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Presynaptic Membrane Organization Anaphase-promoting Complex Binding Postsynaptic Density Assembly Forebrain Morphogenesis Presynaptic Membrane Assembly Protein Serine/threonine Phosphatase Complex Locomotor Rhythm Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Postsynaptic Specialization Assembly Schmidt-Lanterman Incisure Negative Regulation Of Excitatory Postsynaptic Potential Maternal Behavior Long-chain Fatty Acyl-CoA Hydrolase Activity Phosphatidylinositol-3-phosphate Phosphatase Activity Prepulse Inhibition Meiotic Spindle Assembly
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