GZMA and LMNB1

Number of citations of the paper that reports this interaction (PubMedID 11331782)
47

Data Source:
HPRD (in vivo, in vitro)

		GZMA	LMNB1
Description		granzyme A	lamin B1
Image
GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Extracellular Space Nucleus Cytoplasm	Nucleus Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nuclear Lamina Nucleoplasm Intermediate Filament Membrane Nuclear Matrix Nuclear Membrane Nuclear Periphery
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Homodimerization Activity	Double-stranded DNA Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipase Binding Structural Constituent Of Nuclear Lamina Sequence-specific Double-stranded DNA Binding
	Biological Process	Proteolysis Apoptotic Process Immune Response Response To Bacterium Killing Of Cells Of Another Organism Negative Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Oxidoreductase Activity Proteolysis Involved In Protein Catabolic Process Protein Maturation Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Cell Death	Nuclear Envelope Organization Cytoskeleton Organization Nuclear Migration Heterochromatin Formation Nuclear Pore Localization Protein Localization To Nuclear Envelope
Pathways			Meiotic synapsis Formation of Senescence-Associated Heterochromatin Foci (SAHF) Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina Depolymerization of the Nuclear Lamina Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation RHOD GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Body fat percentage ( 31752434) Parkinson's disease (motor and cognition) ( 22658654)
Interacting Genes		17 interacting genes: ACTG1 APEX1 GOLGA2 H1-1 H2BC21 HDC HMGB2 HNRNPK HSP90AA1 HSPA4 LMNA LMNB1 NCL NDUFS3 SET XRCC5 XRCC6	42 interacting genes: ABCG8 ATF4 CASP3 CASP6 CCDC88B CDK1 CENPH DMAP1 FAM169A GABARAP GIT2 GZMA GZMB KPNA5 KPNA6 LBR LMNA M1AP MAP1LC3A MAP1LC3C MBIP MELK PIAS2 PIH1D2 PLEC PPP1R13B PRKCA PRKCB PRKCD PRPH PTEN RNF123 SERPINA3 SNAPIN SRPK2 SUMO4 TMPO TOR1AIP1 TP53BP2 UBE2I URB2 YWHAQ
Entrez ID		3001	4001
HPRD ID		00771	01036
Ensembl ID		ENSG00000145649	ENSG00000113368
Uniprot IDs		P12544	B4DZT3 P20700
PDB IDs		1OP8 1ORF	2KPW 3JT0 3TYY 3UMN 5BNW 5VVX 7DTG
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Double-stranded Telomeric DNA Binding Double-stranded DNA Binding Damaged DNA Binding Chromosome Organization Chromatin Organization Structural Constituent Of Nuclear Lamina Telomere Maintenance Telomeric DNA Binding DNA End Binding Ku70:Ku80 Complex Protein-containing Complex Assembly Negative Regulation Of Metabolic Process Nucleosome Assembly Protein-containing Complex Organization DNA Metabolic Process Telomere Organization DNA-dependent Protein Kinase Complex Nucleosome Organization Lamin Filament Nuclear Pore Localization Negative Regulation Of Macromolecule Metabolic Process DNA Binding DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Nonhomologous End Joining Complex Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Double-strand Break Repair Via Nonhomologous End Joining Nuclear Telomere Cap Complex Negative Regulation Of Biosynthetic Process Protein-DNA Complex Assembly Chromosome Cellular Component Assembly Nuclear Lamina Protein Localization To Nuclear Envelope Organelle Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Recombination Protein-containing Complex Nucleus Organization Structural Constituent Of Cytoskeleton Positive Regulation Of Biosynthetic Process Response To Salt Stress Nucleoplasm Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Telomere Maintenance	Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Cell Death Apoptotic Process Programmed Cell Death Nuclear Membrane Organization Protein Kinase C Signaling Cellular Response To Nitrogen Starvation Intracellular Signal Transduction Mitotic Nuclear Membrane Disassembly Membrane Organization Cytoplasm Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Phosphatidylethanolamine Binding Nuclear Membrane Disassembly Nuclear Inner Membrane Histone H3T6 Kinase Activity Autophagosome Maturation Membrane Disassembly Lamin Binding Nucleoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Cytosol Nuclear Envelope Response To Stress Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Response To Oxidative Stress Nucleus Regulation Of Programmed Cell Death Intracellular Signaling Cassette Cellular Response To Staurosporine SUMO Ligase Complex Regulation Of Protein Localization To Nucleus Positive Regulation Of Apoptotic Process Response To Reactive Oxygen Species Positive Regulation Of Programmed Cell Death Nucleus Organization Response To Hydrogen Peroxide Protein Maturation Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Import Into Nucleus Regulation Of Endodeoxyribonuclease Activity Cardiac Muscle Cell Development Cellular Response To Oxidative Stress Cardiac Cell Development Protein Phosphorylation Protein Serine Kinase Activity
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