GZMA and HNRNPK

Number of citations of the paper that reports this interaction (PMID 19059912)
11

Data Source:
BioGRID (enzymatic study)

		GZMA	HNRNPK
Gene Name		granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	heterogeneous nuclear ribonucleoprotein K
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Gene Ontology Annotations	Cellular Component	Immunological Synapse Extracellular Region Nucleus	Nuclear Chromatin Podosome Nucleus Nucleoplasm Cytoplasm Focal Adhesion Membrane Cell Projection Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Protein Homodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Single-stranded DNA Binding RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Apoptotic Process Immune Response Cytolysis Negative Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Oxidoreductase Activity Proteolysis Involved In Cellular Protein Catabolic Process	MRNA Splicing, Via Spliceosome Transcription, DNA-templated RNA Processing Signal Transduction RNA Splicing Gene Expression Regulation Of Low-density Lipoprotein Particle Clearance Viral Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ACTG1 APEX1 GOLGA2 HDC HIST1H1A HIST2H2BE HMGB2 HNRNPK HSP90AA1 HSPA4 LMNA LMNB1 NCL NDUFS3 SET XRCC5 XRCC6	107 interactors: ABI2 APBB1 AQP5 BTRC C6orf226 CBLB CCAR1 CCDC33 CDKN1A CEBPB CIRBP CNNM3 CSK CTNNBL1 DALRD3 DDX1 DDX17 DDX5 DHX9 DIDO1 DOCK2 EIF3F ELAVL1 FBXL18 FYN GFI1B GRAP2 GRB2 GZMA GZMK HCK HIST3H3 HMGB1 HNRNPA0 HNRNPD HNRNPL HNRNPLL ITK ITSN2 KHDRBS1 KHDRBS2 KHDRBS3 LYN MAPK10 MARK4 MATR3 NCK2 NEDD4 NPDC1 PABPC1 PCBP1 PCBP2 PCDHB14 PELI2 PIN1 PPP1R10 PRKCD PRMT1 PRPF31 PRPF40A PRR3 PTBP1 QKI RALY RASD1 RBFOX2 RBM10 RBM3 RBM4 RBM41 RBM42 RBM7 RBMX RBMY1A1 RBMY1F RNA18S5 RNA28S5 RTP5 SAFB SF1 SMAD3 SNRPA SORBS3 SPG7 SRC SREK1 SRRT SRSF3 SUMO1 SYNCRIP TBP TCERG1 TERF2IP TYK2 U2AF1 U2AF2 UBE2I VAV1 WBP4 WWOX YBX1 YTHDC1 YWHAQ ZFC3H1 ZNF385C ZNF792 ZNRF2P1
Entrez ID		3001	3190
HPRD ID		00771	02834
Ensembl ID		ENSG00000145649	ENSG00000165119
Uniprot IDs		P12544	B4DFF1 B4DUQ1 P61978 Q6IBN1
PDB IDs		1HF1 1OP8 1ORF	1J5K 1KHM 1ZZI 1ZZJ 1ZZK
Enriched GO Terms of Interacting Partners?		DNA Conformation Change Cellular Hyperosmotic Salinity Response Organelle Organization Nucleosome Assembly Chromatin Assembly Protein Import Into Mitochondrial Outer Membrane Nucleosome Organization Cellular Macromolecular Complex Assembly Chromosome Organization Chromatin Assembly Or Disassembly Cellular Response To X-ray Protein-DNA Complex Assembly DNA Packaging Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Establishment Of Integrated Proviral Latency Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency DNA Recombination Execution Phase Of Apoptosis Telomere Maintenance Cellular Response To Salt Stress Chaperone-mediated Protein Complex Assembly DNA Ligation Protein Complex Assembly Double-strand Break Repair Via Nonhomologous End Joining Response To Unfolded Protein Hyperosmotic Response Mitotic Cell Cycle Double-strand Break Repair Protein Import Cellular Component Assembly Innate Immune Response V(D)J Recombination Cellular Response To Osmotic Stress Response To Stress Response To X-ray Response To Salt Stress Cellular Response To Stress Positive Regulation Of Cellular Biosynthetic Process Intracellular Protein Transmembrane Transport DNA Metabolic Process DNA Repair Positive Regulation Of Nuclease Activity Negative Regulation Of Apoptotic Signaling Pathway Sterol Regulatory Element Binding Protein Import Into Nucleus Cellular Response To Ionizing Radiation Protein Transmembrane Transport Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process	RNA Processing MRNA Processing RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Posttranscriptional Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Immune Response Positive Regulation Of Metabolic Process MRNA Stabilization Innate Immune Response Regulation Of Nitrogen Compound Metabolic Process Regulation Of MRNA Processing Peptidyl-tyrosine Autophosphorylation Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Metabolic Process Regulation Of Translation Negative Regulation Of Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Immune System Process Positive Regulation Of Gene Expression Regulation Of Immune System Process Defense Response Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction T Cell Costimulation Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		ark boosting bronchitis calt cd3 cd44 chickens compartment compartments contraction cytotoxic effector granzyme halt homing humoral ibv lesser lymphocyte mirrored mucosal ocular ocularly perforin poultry presumably shifted spleen vaccinated	associates boosted consequently cpg dnmt1 facilitated h3k9 h3k9me3 heterochromatin impairs insight instead intergenic lincrna link lncrnas methyltransferase noncoding notably p21 pluripotency prevents profiling promoters reprogramming rnas setdb1 somatic sustaining
Tagcloud (Difference) ?		ark boosting bronchitis calt cd3 cd44 chickens compartment compartments contraction cytotoxic effector granzyme halt homing humoral ibv lesser lymphocyte mirrored mucosal ocular ocularly perforin poultry presumably shifted spleen vaccinated	associates boosted consequently cpg dnmt1 facilitated h3k9 h3k9me3 heterochromatin impairs insight instead intergenic lincrna link lncrnas methyltransferase noncoding notably p21 pluripotency prevents profiling promoters reprogramming rnas setdb1 somatic sustaining
Tagcloud (Intersection) ?