GZMA and NDUFS3

Number of citations of the paper that reports this interaction (PMID 18485875)
23

Data Source:
BioGRID (enzymatic study)

		GZMA	NDUFS3
Gene Name		granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Extracellular Region Nucleus	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Mitochondrial Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Protein Homodimerization Activity	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Carrier Activity
	Biological Process	Apoptotic Process Immune Response Cytolysis Negative Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Oxidoreductase Activity Proteolysis Involved In Cellular Protein Catabolic Process	Mitochondrial Electron Transport, NADH To Ubiquinone Substantia Nigra Development Respiratory Electron Transport Chain Negative Regulation Of Cell Growth Cellular Metabolic Process Small Molecule Metabolic Process Reactive Oxygen Species Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH
Diseases
GWAS			Body mass index ( 20935630)
Protein-Protein Interactions		17 interactors: ACTG1 APEX1 GOLGA2 HDC HIST1H1A HIST2H2BE HMGB2 HNRNPK HSP90AA1 HSPA4 LMNA LMNB1 NCL NDUFS3 SET XRCC5 XRCC6	2 interactors: GZMA RASL10B
Entrez ID		3001	4722
HPRD ID		00771	10355
Ensembl ID		ENSG00000145649	ENSG00000213619
Uniprot IDs		P12544	O75489
PDB IDs		1HF1 1OP8 1ORF
Enriched GO Terms of Interacting Partners?		DNA Conformation Change Cellular Hyperosmotic Salinity Response Organelle Organization Nucleosome Assembly Chromatin Assembly Protein Import Into Mitochondrial Outer Membrane Nucleosome Organization Cellular Macromolecular Complex Assembly Chromosome Organization Chromatin Assembly Or Disassembly Cellular Response To X-ray Protein-DNA Complex Assembly DNA Packaging Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Establishment Of Integrated Proviral Latency Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency DNA Recombination Execution Phase Of Apoptosis Telomere Maintenance Cellular Response To Salt Stress Chaperone-mediated Protein Complex Assembly DNA Ligation Protein Complex Assembly Double-strand Break Repair Via Nonhomologous End Joining Response To Unfolded Protein Hyperosmotic Response Mitotic Cell Cycle Double-strand Break Repair Protein Import Cellular Component Assembly Innate Immune Response V(D)J Recombination Cellular Response To Osmotic Stress Response To Stress Response To X-ray Response To Salt Stress Cellular Response To Stress Positive Regulation Of Cellular Biosynthetic Process Intracellular Protein Transmembrane Transport DNA Metabolic Process DNA Repair Positive Regulation Of Nuclease Activity Negative Regulation Of Apoptotic Signaling Pathway Sterol Regulatory Element Binding Protein Import Into Nucleus Cellular Response To Ionizing Radiation Protein Transmembrane Transport Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Negative Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Nuclease Activity Regulation Of Systemic Arterial Blood Pressure By Atrial Natriuretic Peptide Regulation Of Endodeoxyribonuclease Activity Cytolysis Negative Regulation Of Oxidoreductase Activity Negative Regulation Of DNA Binding Regulation Of Oxidoreductase Activity Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Regulation Of DNA Binding Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of DNA Metabolic Process Negative Regulation Of Binding Positive Regulation Of Hormone Secretion
Tagcloud ?		ark boosting bronchitis calt cd3 cd44 chickens compartment compartments contraction cytotoxic effector granzyme halt homing humoral ibv lesser lymphocyte mirrored mucosal ocular ocularly perforin poultry presumably shifted spleen vaccinated	accounting agf3l2 assembly c20orf7 c8orf38 chase confirming docks holoenzyme immunoprecipitated knock knocked labeling module mtdna nadh nd1 ndufa9 ndufaf2 ndufaf4 nucleating oxidoreductase proteolysis pulse redundant stabilizes ubiquinone
Tagcloud (Difference) ?		ark boosting bronchitis calt cd3 cd44 chickens compartment compartments contraction cytotoxic effector granzyme halt homing humoral ibv lesser lymphocyte mirrored mucosal ocular ocularly perforin poultry presumably shifted spleen vaccinated	accounting agf3l2 assembly c20orf7 c8orf38 chase confirming docks holoenzyme immunoprecipitated knock knocked labeling module mtdna nadh nd1 ndufa9 ndufaf2 ndufaf4 nucleating oxidoreductase proteolysis pulse redundant stabilizes ubiquinone
Tagcloud (Intersection) ?