GZMA and HDC

Number of citations of the paper that reports this interaction (PubMedID 19059912)
0

Data Source:
BioGRID (enzymatic study)

		GZMA	HDC
Description		granzyme A	histidine decarboxylase
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GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Extracellular Space Nucleus Cytoplasm	Cytoplasm Cytosol
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Homodimerization Activity	Histidine Decarboxylase Activity Protein Binding Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding
	Biological Process	Proteolysis Apoptotic Process Immune Response Response To Bacterium Killing Of Cells Of Another Organism Negative Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Oxidoreductase Activity Proteolysis Involved In Protein Catabolic Process Protein Maturation Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Cell Death	Histamine Biosynthetic Process Amino Acid Metabolic Process L-histidine Metabolic Process L-histidine Catabolic Process Carboxylic Acid Metabolic Process Biogenic Amine Biosynthetic Process Catecholamine Biosynthetic Process
Pathways			Histidine catabolism
Drugs			Pyridoxal phosphate Histidine
Diseases			Tourette syndrome
GWAS			Basophil count ( 32888494) Lung function (FEV1/FVC) ( 30061609)
Interacting Genes		17 interacting genes: ACTG1 APEX1 GOLGA2 H1-1 H2BC21 HDC HMGB2 HNRNPK HSP90AA1 HSPA4 LMNA LMNB1 NCL NDUFS3 SET XRCC5 XRCC6	2 interacting genes: DTX2 GZMA
Entrez ID		3001	3067
HPRD ID		00771	00817
Ensembl ID		ENSG00000145649	ENSG00000140287
Uniprot IDs		P12544	P19113
PDB IDs		1OP8 1ORF	4E1O 7EIW 7EIX 7EIY
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Double-stranded Telomeric DNA Binding Double-stranded DNA Binding Damaged DNA Binding Chromosome Organization Chromatin Organization Structural Constituent Of Nuclear Lamina Telomere Maintenance Telomeric DNA Binding DNA End Binding Ku70:Ku80 Complex Protein-containing Complex Assembly Negative Regulation Of Metabolic Process Nucleosome Assembly Protein-containing Complex Organization DNA Metabolic Process Telomere Organization DNA-dependent Protein Kinase Complex Nucleosome Organization Lamin Filament Nuclear Pore Localization Negative Regulation Of Macromolecule Metabolic Process DNA Binding DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Nonhomologous End Joining Complex Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Double-strand Break Repair Via Nonhomologous End Joining Nuclear Telomere Cap Complex Negative Regulation Of Biosynthetic Process Protein-DNA Complex Assembly Chromosome Cellular Component Assembly Nuclear Lamina Protein Localization To Nuclear Envelope Organelle Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Recombination Protein-containing Complex Nucleus Organization Structural Constituent Of Cytoskeleton Positive Regulation Of Biosynthetic Process Response To Salt Stress Nucleoplasm Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Telomere Maintenance	Negative Regulation Of Deoxyribonuclease Activity Negative Regulation Of Endodeoxyribonuclease Activity Cytotoxic T Cell Pyroptotic Cell Death Negative Regulation Of Nuclease Activity Negative Regulation Of Oxidoreductase Activity Regulation Of Endodeoxyribonuclease Activity Granzyme-mediated Programmed Cell Death Signaling Pathway Negative Regulation Of DNA Binding Pyroptotic Cell Death Regulation Of Oxidoreductase Activity Immunological Synapse Pyroptotic Inflammatory Response Regulation Of DNA Binding
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