QPCT

Description		glutaminyl-peptide cyclotransferase
Image
GO Annotations	Cellular Component	Extracellular Region Specific Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Zinc Ion Binding Glutaminyl-peptide Cyclotransferase Activity Transferase Activity Acyltransferase Activity Metal Ion Binding
	Biological Process	Peptidyl-pyroglutamic Acid Biosynthetic Process, Using Glutaminyl-peptide Cyclotransferase Protein Modification Process
Pathways		Neutrophil degranulation
Drugs		1-benzylimidazole N-acetylhistamine Glutamine t-butyl ester
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 28892062) Chronic lymphocytic leukemia ( 24292274 26956414 28165464) HDL cholesterol levels in HIV infection ( 33109212) Height ( 31562340) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Schizophrenia ( 23974872 30285260)
Novel Interacting Genes		1 novel interacting genes: CFLAR
Interacting Genes		2 interacting genes: HRAS UBQLN2
Entrez ID		25797
HPRD ID		06140
Ensembl ID		ENSG00000115828
Uniprot IDs		Q16769
PDB IDs		2AFM 2AFO 2AFS 2AFU 2AFW 2AFX 2AFZ 2ZED 2ZEE 2ZEF 2ZEG 2ZEH 2ZEL 2ZEM 2ZEN 2ZEO 2ZEP 3PBB 3PBE 3SI0 4YU9 4YWY 6GBX 6YI1 6YJY 7CM0 7COZ 7CP0 7D8E 8HY3 8XGB 8XGT 8XGY 9ISD 9IVV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Epithelial Cell Proliferation Phospholipase C Activator Activity Regulation Of ERK1 And ERK2 Cascade Oncogene-induced Cell Senescence Regulation Of Neuron Apoptotic Process Apoptotic Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade GTPase Complex Ripoptosome Negative Regulation Of Hepatocyte Apoptotic Process Skeletal Myofibril Assembly Negative Regulation Of Myoblast Fusion Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Death-inducing Signaling Complex Skeletal Muscle Atrophy CD95 Death-inducing Signaling Complex Skeletal Muscle Adaptation Striated Muscle Atrophy Positive Regulation Of Glomerular Mesangial Cell Proliferation Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Cell Projection Organization Regulation Of Epithelial Cell Proliferation T-helper 1 Type Immune Response Muscle Atrophy Positive Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Hepatocyte Proliferation Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Positive Regulation Of Ruffle Assembly Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Skeletal Muscle Cell Proliferation Cellular Response To Nitric Oxide Death Receptor Binding Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Hepatocyte Proliferation Regulation Of Skeletal Muscle Satellite Cell Proliferation Cellular Response To Reactive Nitrogen Species Positive Regulation Of ERAD Pathway Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis Schwann Cell Development Response To Nitric Oxide Regulation Of Myoblast Fusion Skeletal Muscle Tissue Regeneration Regulation Of Protein Targeting To Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization Tissue Development
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