A1CF and APOBEC1

Number of citations: 51 (PubMedID 12881431)
Data Source: HPRD (in vitro, in vivo)

		A1CF	APOBEC1
Name		APOBEC1 complementation factor	apolipoprotein B mRNA editing enzyme catalytic subunit 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Apolipoprotein B MRNA Editing Enzyme Complex MRNA Editing Complex	Nucleus Nucleoplasm Cytoplasm Apolipoprotein B MRNA Editing Enzyme Complex MRNA Editing Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Enzyme-substrate Adaptor Activity	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding
	Biological Process	MRNA Processing Embryo Implantation MRNA Localization Resulting In Post-transcriptional Regulation Of Gene Expression Cytidine To Uridine Editing MRNA Modification Low-density Lipoprotein Particle Clearance Protein Stabilization Chromosomal 5-methylcytosine DNA Demethylation Pathway Negative Regulation Of MRNA Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	MRNA Processing Lipid Metabolic Process Triglyceride Metabolic Process Response To Gamma Radiation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Cytidine To Uridine Editing MRNA Modification Low-density Lipoprotein Particle Clearance Regulation Of Cell Population Proliferation Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Transport Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation MRNA Stabilization Establishment Of Localization In Cell Negative Regulation Of Triglyceride Metabolic Process Chromosomal 5-methylcytosine DNA Demethylation Pathway Regulation Of MRNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways		mRNA Editing: C to U Conversion Formation of the Editosome	mRNA Editing: C to U Conversion Formation of the Editosome
Drugs		None	Zinc chloride Zinc sulfate, unspecified form
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134 ) Colorectal cancer or advanced adenoma ( 30510241 ) Estimated glomerular filtration rate ( 31451708 31152163 31015462 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Gamma glutamyl transferase levels ( 33339817 ) Glomerular filtration rate (creatinine) ( 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Interferon alpha levels in systemic lupus erythematosus ( 25338677 ) LDL cholesterol ( 30275531 ) Low density lipoprotein cholesterol levels ( 32154731 ) Narcolepsy with cataplexy ( 25986216 ) Serum uric acid levels ( 30993211 ) Total cholesterol levels ( 30275531 ) Triglyceride levels ( 32154731 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglycerides ( 30275531 ) Urate levels ( 31578528 31985003 23263486 ) Urate levels in lean individuals ( 25811787 )	Body mass index ( 28552196 ) Creatine kinase levels ( 29403010 ) HDL cholesterol levels ( 28334899 )
Interacting Genes		26 interacting genes: ACTMAP APOBEC1 CAVIN2 CELF2 CYSRT1 DOK3 ECM1 EIF4G1 FHL2 FHL3 HSPB2 HSPB2-C11orf52 KHSRP KLHDC7B KRT31 KRT34 METTL27 OIP5 PLEKHG4 POGZ REL RIMBP3C SPMIP6 SYNCRIP TNPO2 TRAF1	16 interacting genes: A1CF APOBEC2 BAG4 CDK6 CELF2 DNAJB11 DND1 HNRNPF HNRNPK KPNA2 KRTAP19-5 KRTAP6-1 KRTAP6-2 NOTO SYNCRIP UFSP2
Entrez ID		29974	339
HPRD ID		10627	02531
Ensembl ID		ENSG00000148584	ENSG00000111701
Uniprot IDs		B4E1E3 F8W9F8 Q9NQ94	P41238
PDB IDs		2CPD	6X91
GO Terms Enriched among Interactors		Chromosomal 5-methylcytosine DNA Demethylation Pathway MRNA Editing Complex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Modification Manchette	MRNA Modification Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Metabolic Process MRNA Processing RNA Binding MRNA Editing Complex Chromosomal 5-methylcytosine DNA Demethylation Pathway Nucleic Acid Binding RNA Modification Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytidine To Uridine Editing Negative Regulation Of MRNA Catabolic Process Catalytic Step 2 Spliceosome Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Processing Negative Regulation Of RNA Catabolic Process Base Conversion Or Substitution Editing RNA Metabolic Process Nucleic Acid Metabolic Process Ribonucleoprotein Complex Intermediate Filament Spliceosomal Complex Regulation Of RNA Splicing Positive Regulation Of Gene Expression Cyclin D2-CDK6 Complex MRNA Splicing, Via Spliceosome Single-stranded RNA Binding Negative Regulation Of MRNA Modification Nucleus Regulation Of Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Nucleobase-containing Compound Metabolic Process MRNA Binding Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin MRNA Stabilization DeUFMylase Activity Regulation Of Primary Metabolic Process Keratinization Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process RNA Stabilization MRNA Localization Resulting In Post-transcriptional Regulation Of Gene Expression