A1CF and SPMIP6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		A1CF	SPMIP6
Description		APOBEC1 complementation factor	sperm microtubule inner protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Apolipoprotein B MRNA Editing Enzyme Complex MRNA Editing Complex	Manchette Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Cilium Motile Cilium Sperm Flagellum Cell Projection Perinuclear Region Of Cytoplasm Sperm Midpiece Axonemal A Tubule Inner Sheath
	Molecular Function	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Enzyme-substrate Adaptor Activity	Protein Binding Alpha-tubulin Binding
	Biological Process	MRNA Processing Embryo Implantation MRNA Localization Resulting In Post-transcriptional Regulation Of Gene Expression Cytidine To Uridine Editing MRNA Modification Low-density Lipoprotein Particle Clearance Protein Stabilization Chromosomal 5-methylcytosine DNA Demethylation Pathway Negative Regulation Of MRNA Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Spermatogenesis Cell Differentiation Flagellated Sperm Motility Protein-containing Complex Assembly
Pathways		mRNA Editing: C to U Conversion Formation of the Editosome
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31451708 31152163 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) Gamma glutamyl transferase levels ( 33339817) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Interferon alpha levels in systemic lupus erythematosus ( 25338677) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731) Narcolepsy with cataplexy ( 25986216) Serum uric acid levels ( 30993211) Total cholesterol levels ( 30275531) Triglyceride levels ( 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531) Urate levels ( 31578528 31985003 23263486) Urate levels in lean individuals ( 25811787)
Interacting Genes		26 interacting genes: ACTMAP APOBEC1 CAVIN2 CELF2 CYSRT1 DOK3 ECM1 EIF4G1 FHL2 FHL3 HSPB2 HSPB2-C11orf52 KHSRP KLHDC7B KRT31 KRT34 METTL27 OIP5 PLEKHG4 POGZ REL RIMBP3C SPMIP6 SYNCRIP TNPO2 TRAF1	27 interacting genes: A1CF AIRIM BCAS2 BCL6 CABP2 CATSPER1 CCDC57 CDR2L CLIC3 COL8A1 CYSRT1 HGS HSF2BP KCTD9 KRTAP19-5 KRTAP19-6 KRTAP9-3 MEIS2 NOXA1 PIK3R3 PROP1 RBPMS SHBG SPG21 TEKT4 TSSK3 UBASH3A
Entrez ID		29974	84688
HPRD ID		10627	12949
Ensembl ID		ENSG00000148584	ENSG00000164972
Uniprot IDs		B4E1E3 F8W9F8 Q9NQ94	A0A8I5KRB0 Q8NCR6
PDB IDs		2CPD
Enriched GO Terms of Interacting Partners?		Chromosomal 5-methylcytosine DNA Demethylation Pathway MRNA Editing Complex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Modification Manchette
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