ZNF326 and KPNA5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF326	KPNA5
Description		zinc finger protein 326	karyopherin subunit alpha 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Matrix DBIRD Complex	Nucleus Nucleoplasm Cytoplasm Cytosol NLS-dependent Protein Nuclear Import Complex
	Molecular Function	RNA Polymerase II Complex Binding DNA Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	MRNA Processing RNA Splicing Regulation Of DNA-templated Transcription Elongation Regulation Of RNA Splicing	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport
Pathways			ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Brain structure (hippocampal volume) ( 20197096) Major depressive disorder ( 27479909) Obsessive-compulsive symptoms ( 26859814) Thiopurine-induced digestive symptoms in inflammatory bowel disease ( 29923122)	Early cardiac repolarization ( 31600170) Telomere length ( 21460395)
Interacting Genes		9 interacting genes: GEMIN4 GYS1 KHDRBS3 KPNA5 NCOA5 PTEN SLC26A4-AS1 SPTA1 VMAC	29 interacting genes: ANP32A ANP32B ARNT ATM ATOSB BRMS1 CDKN1B CFTR DCPS EPAS1 FBXO7 HIF1A HNRNPC IL32 KAT5 LMNB1 MLH1 NMNAT1 NRF1 POLR3C POU6F2 RAD52 RBBP4 SPOP SPOPL TSEN54 TWIST1 WT1 ZNF326
Entrez ID		284695	3841
HPRD ID		15774	05179
Ensembl ID		ENSG00000162664	ENSG00000196911
Uniprot IDs		A0A0A0MRN4 Q5BKZ1	A0A8V8TL88 A0A8V8TMV2 O15131
PDB IDs			4U2X
Enriched GO Terms of Interacting Partners?			Nucleoplasm Nucleus Negative Regulation Of DNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Positive Regulation Of Catabolic Process Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Multicellular Organismal Process DNA Double-strand Break Processing Embryonic Placenta Development Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Apoptotic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macroautophagy Cellular Response To Stress Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Chromatin Negative Regulation Of Double-strand Break Repair Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA Repair MRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Developmental Process Histone Deacetylase Binding Regulation Of Protein Modification Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation DNA Damage Response, Signal Transduction By P53 Class Mediator Chromatin Remodeling Negative Regulation Of DNA Recombination Positive Regulation Of Hormone Biosynthetic Process DNA-binding Transcription Factor Activity
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