ZBTB33 and GSDMD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZBTB33	GSDMD
Description		zinc finger and BTB domain containing 33	gasdermin D
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Mitochondrial Membrane Specific Granule Lumen Canonical Inflammasome Complex NLRP3 Inflammasome Complex Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Cardiolipin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Wnt Signaling Pathway Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription	Plasma Membrane Repair Immune System Process Inflammatory Response Protein Secretion Programmed Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium NLRP3 Inflammasome Complex Assembly Innate Immune Response Ceramide Biosynthetic Process Pore Complex Assembly Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Protein Homooligomerization Protein Maturation Transmembrane Transport Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Pyroptotic Cell Death
Pathways		Negative Regulation of CDH1 Gene Transcription	Release of apoptotic factors from the mitochondria Interleukin-1 processing Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Purinergic signaling in leishmaniasis infection CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Monocyte count ( 32888494) Schizophrenia ( 31268507)
Interacting Genes		9 interacting genes: CBFA2T3 CTNND1 GSDMD GYS1 NCOR1 NUDT22 SUMO2 SUMO3 TRIM28	9 interacting genes: ASPG CASP1 KCTD6 MEOX2 MFHAS1 PSMA1 ZBTB33 ZNF426 ZNF558
Entrez ID		10009	79792
HPRD ID		02269	11014
Ensembl ID		ENSG00000177485	ENSG00000104518
Uniprot IDs		Q86T24	P57764
PDB IDs		2LT7 3FKC 3M4T 3M8V 4F6M 4F6N 5VMU 5VMV 5VMW 5VMX 5VMY 5VMZ 6DF5 6DF8 6DF9 6DFA 6DFB 6DFC 6V8U	5NH1 5WQT 6AO4 6KN0 6N9O 6VFE 7Z1X
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Negative Regulation Of Glycolytic Process Regulation Of Generation Of Precursor Metabolites And Energy Protein Tag Activity SUMO Transferase Activity Negative Regulation Of D-glucose Transmembrane Transport Negative Regulation Of ATP Metabolic Process Ubiquitin-like Protein Ligase Binding Transcription Corepressor Activity Regulation Of Glycolytic Process Negative Regulation Of Blood Vessel Branching Structural Constituent Of Presynaptic Actin Cytoskeleton GDP-mannose Hydrolase Activity Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of D-glucose Transmembrane Transport Glycogen Synthase Activity, Transferring Glucose-1-phosphate Krueppel-associated Box Domain Binding Derlin-1-VIMP Complex UDP-sugar Diphosphatase Activity Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Ubiquitin-like Protein Ligase Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Negative Regulation Of Small Molecule Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Transmembrane Transport Positive Regulation Of Protein Localization To Cell-cell Junction Embryonic Placenta Morphogenesis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Localization To Cell-cell Junction Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation Convergent Extension Involved In Axis Elongation Chromo Shadow Domain Binding Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus
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