CCDC106 and CACNA1S

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCDC106	CACNA1S
Description		coiled-coil domain containing 106	calcium voltage-gated channel subunit alpha1 S
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Sarcoplasmic Reticulum T-tubule I Band Monoatomic Ion Channel Complex L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Protein Binding	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Small Molecule Binding Metal Ion Binding Molecular Function Activator Activity
	Biological Process		Skeletal System Development Extraocular Skeletal Muscle Development Monoatomic Ion Transport Calcium Ion Transport Muscle Contraction Striated Muscle Contraction Endoplasmic Reticulum Organization Skeletal Muscle Tissue Development Myoblast Fusion Neuromuscular Junction Development Monoatomic Ion Transmembrane Transport Skeletal Muscle Adaptation Positive Regulation Of Muscle Contraction Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Muscle Cell Development Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Calcium Ion Import Across Plasma Membrane
Pathways			NCAM1 interactions
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Magnesium sulfate Verapamil Levomenthol Ethanol Felodipine Nitrendipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Clevidipine Nilvadipine Nilvadipine Drotaverine Trimebutine Pinaverium Aranidipine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases			Hypokalemic periodic paralysis (HypoPP)
GWAS			Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 30604766 31015462 31152163) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Permanent tooth development ( 21931568) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tooth agenesis ( 29364747) Ulcerative colitis ( 28067908 20228799) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		26 interacting genes: APP ATF4 CACNA1S CEP19 COPS6 CRMP1 EEF1G EIF1AD ERG28 FAM9B KAT5 KBTBD7 L3MBTL2 LRIF1 MAGEA11 MAGOHB NAA10 NKAPD1 NUTF2 PRPF31 RBM48 RCOR3 SDCBP SETDB1 TP53 UTP14A	9 interacting genes: CCDC106 CYSRT1 MEOX2 NHERF4 REL RIMS2 RYR1 SRI TNKS
Entrez ID		29903	779
HPRD ID		09995	00248
Ensembl ID		ENSG00000173581	ENSG00000081248
Uniprot IDs		K7EMI9 Q9BWC9	B1ALM3 Q13698
PDB IDs			2VAY 6B27
Enriched GO Terms of Interacting Partners?		Nucleoplasm Promoter-specific Chromatin Binding Molecular Function Activator Activity Nucleus Cellular Response To Glucose Starvation Cellular Response To Manganese Ion Negative Regulation Of Gene Expression Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Manganese Ion General Transcription Initiation Factor Binding Negative Regulation Of Biosynthetic Process Cytosol Acetyltransferase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Transcription Regulator Complex	Regulation Of CGMP-mediated Signaling Epithelium Development Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Regulation Of Cell Migration Involved In Sprouting Angiogenesis Sarcoplasmic Reticulum Membrane FMN Transmembrane Transporter Activity FAD Transmembrane Transporter Activity FAD Transmembrane Transport Guanylate Cyclase Inhibitor Activity
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