CCDC106 and L3MBTL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCDC106	L3MBTL2
Description		coiled-coil domain containing 106	L3MBTL histone methyl-lysine binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm
	Molecular Function	Protein Binding	Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding Histone H4K20me2 Reader Activity Histone H4K20me1 Reader Activity Promoter-specific Chromatin Binding
	Biological Process		Chromatin Organization Regulation Of DNA-templated Transcription Ectoderm Development Negative Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Stem Cell Differentiation Stem Cell Proliferation
Pathways			SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS			Adventurousness ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 26192919) Depression ( 29700475) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 26192919) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Neuroticism ( 27918536 29255261) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		26 interacting genes: APP ATF4 CACNA1S CEP19 COPS6 CRMP1 EEF1G EIF1AD ERG28 FAM9B KAT5 KBTBD7 L3MBTL2 LRIF1 MAGEA11 MAGOHB NAA10 NKAPD1 NUTF2 PRPF31 RBM48 RCOR3 SDCBP SETDB1 TP53 UTP14A	49 interacting genes: AMOTL2 BEND7 BIVM CARD9 CCDC106 CCDC33 CEP76 DRC4 EFHC2 EIF4ENIF1 FAM217B GKAP1 GOLGA2 GPRASP3 H3C1 H4C1 HSF2BP LNX2 MEAF6 MEOX1 MPP3 NRF1 PAICS PHF10 PIAS1 PICK1 POU6F2 PRKAR1B RBAK REL SSUH2 STAC3 STAM2 TAX1BP1 TBC1D9B TEKT1 THAP1 THAP11 TLE5 TNNI1 TRIM42 TRIM50 TSPYL1 ZBTB26 ZBTB48 ZFP64 ZFY ZNF467 ZNF829
Entrez ID		29903	83746
HPRD ID		09995	13954
Ensembl ID		ENSG00000173581	ENSG00000100395
Uniprot IDs		K7EMI9 Q9BWC9	A0A0S2Z5X6 Q969R5
PDB IDs			2W0T 3CEY 3F70
Enriched GO Terms of Interacting Partners?		Nucleoplasm Promoter-specific Chromatin Binding Molecular Function Activator Activity Nucleus Cellular Response To Glucose Starvation Cellular Response To Manganese Ion Negative Regulation Of Gene Expression Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Manganese Ion General Transcription Initiation Factor Binding Negative Regulation Of Biosynthetic Process Cytosol Acetyltransferase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Transcription Regulator Complex	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
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