GTF3C2 and GTF3C4

Number of citations of the paper that reports this interaction (PMID 10523658)
26

Data Source:
HPRD (in vivo, in vitro)

		GTF3C2	GTF3C4
Gene Name		general transcription factor IIIC, polypeptide 2, beta 110kDa	general transcription factor IIIC, polypeptide 4, 90kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Transcription Factor TFIIIC Complex Nucleoplasm	Transcription Factor TFIIIC Complex Nucleoplasm
	Molecular Function	DNA Binding	DNA Binding Histone Acetyltransferase Activity Protein Binding Enzyme Activator Activity
	Biological Process	Transcription, DNA-templated Transcription From RNA Polymerase III Promoter Gene Expression 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter	Transcription, DNA-templated Transcription From RNA Polymerase III Promoter Transcription Initiation From RNA Polymerase III Promoter Gene Expression Histone Acetylation 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter Positive Regulation Of Catalytic Activity
Pathways		RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 2 Promoter	RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: GRIA2 GTF3A GTF3C4 RB1 TBP	11 interactors: BRCA1 BRF1 GTF3C1 GTF3C2 GTF3C5 GTF3C6 HIST2H3A HIST3H3 POLR3C POLR3F TBP
Entrez ID		2976	9329
HPRD ID		05347	11998
Ensembl ID		ENSG00000115207
Uniprot IDs		Q8WUA4	B3KNH2 Q9UKN8
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase III Promoter RRNA Transcription Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Centromere Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin DNA-templated Transcription, Initiation Attachment Of Mitotic Spindle Microtubules To Kinetochore 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter TRNA Transcription RNA Metabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Gene Expression Protein Localization To Chromosome, Centromeric Region Attachment Of Spindle Microtubules To Kinetochore Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macrophage Differentiation Macromolecule Biosynthetic Process Mitotic Sister Chromatid Cohesion Enucleate Erythrocyte Differentiation Chromatin Silencing At RDNA Transcription Initiation From RNA Polymerase III Promoter Positive Regulation Of Chromosome Segregation Regulation Of Sister Chromatid Cohesion Hepatocyte Apoptotic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Viral Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Mitotic Metaphase Plate Congression Nucleobase-containing Compound Metabolic Process Transcription Initiation From RNA Polymerase I Promoter Protein Localization To Chromosome Chromatin Modification Neuron Maturation Sister Chromatid Cohesion Transcription From RNA Polymerase I Promoter Metaphase Plate Congression Negative Regulation Of Smoothened Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Chromatin Silencing Cellular Nitrogen Compound Metabolic Process	Transcription From RNA Polymerase III Promoter TRNA Transcription 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter RRNA Transcription Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase III Promoter Transcription, DNA-templated Gene Expression RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Termination DNA-templated Transcription, Elongation RNA Metabolic Process Biosynthetic Process Chromatin Silencing At RDNA Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Positive Regulation Of Interferon-beta Production Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Chromatin Silencing Regulation Of Interferon-beta Production Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Positive Regulation Of Cytokine Production Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Type I Interferon Production Positive Regulation Of Histone H3-K9 Acetylation Gene Silencing Regulation Of Type I Interferon Production Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Proepicardium Development Regulation Of Cytokine Production Cellular Response To Indole-3-methanol Defense Response To Virus Metabolic Process Negative Regulation Of Centriole Replication Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Innate Immune Response Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation
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