GTF3C2

Description		general transcription factor IIIC subunit 2
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GO Annotations	Cellular Component	Transcription Factor TFIIIC Complex Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase III General Transcription Initiation Factor Activity DNA Binding Protein Binding
	Biological Process	Transcription By RNA Polymerase III 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III
Pathways		RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
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Diseases
GWAS		Menopause (age at onset) ( 26414677) Metabolite levels ( 23823483) Urinary albumin-to-creatinine ratio ( 32600054)
Interacting Genes		10 interacting genes: GRIA2 GTF3A GTF3C4 MECOM PTEN RB1 SUMO2 TBP VAC14 VHL
Entrez ID		2976
HPRD ID		05347
Ensembl ID		ENSG00000115207
Uniprot IDs		Q8WUA4
PDB IDs		8CLI 8CLJ 8CLL
Enriched GO Terms of Interacting Partners?		Transcription By RNA Polymerase III PML Body RNA Polymerase III General Transcription Initiation Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-templated Transcription RRNA Transcription Enzyme Binding DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Synaptic Vesicle Clustering PAS Complex Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Ligand-gated Monoatomic Cation Channel Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol Biosynthetic Process Central Nervous System Myelin Maintenance Negative Regulation Of Protein Phosphorylation Rhythmic Synaptic Transmission Chromatin Lock Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Histone H3K9 Monomethyltransferase Activity Dendritic Spine AMPA Glutamate Receptor Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Myelin Sheath Adaxonal Region Negative Regulation Of Nervous System Development Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity
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