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ERCC2 and ERCC5
Number of citations of the paper that reports this interaction (PubMedID
8652557
)
0
Data Source:
HPRD
(in vitro)
ERCC2
ERCC5
Description
ERCC excision repair 2, TFIIH core complex helicase subunit
ERCC excision repair 5, endonuclease
Image
GO Annotations
Cellular Component
Transcription Factor TFIIH Core Complex
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIH Holo Complex
Cytoplasm
Spindle
Cytosol
Cytoskeleton
CAK-ERCC2 Complex
MMXD Complex
Nucleotide-excision Repair Complex
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Chromosome
Protein-containing Complex
Molecular Function
Nucleotide Binding
Nucleic Acid Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Helicase Activity
Protein Binding
ATP Binding
Hydrolase Activity
Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides
Isomerase Activity
ATP Hydrolysis Activity
Protein-macromolecule Adaptor Activity
5'-3' DNA Helicase Activity
Metal Ion Binding
Iron-sulfur Cluster Binding
4 Iron, 4 Sulfur Cluster Binding
Bubble DNA Binding
RNA Polymerase II Complex Binding
DNA Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Catalytic Activity
Nuclease Activity
Endonuclease Activity
DNA Endonuclease Activity
Protein Binding
Enzyme Activator Activity
Hydrolase Activity
Hydrolase Activity, Acting On Ester Bonds
Protein Homodimerization Activity
Protein-containing Complex Binding
Metal Ion Binding
Biological Process
Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Response To Hypoxia
In Utero Embryonic Development
Nucleobase-containing Compound Metabolic Process
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase I
Transcription By RNA Polymerase II
Transcription Initiation At RNA Polymerase II Promoter
Apoptotic Process
DNA Damage Response
Response To Oxidative Stress
Chromosome Segregation
Determination Of Adult Lifespan
Response To UV
UV Protection
Post-embryonic Development
Spinal Cord Development
Hair Cycle Process
Extracellular Matrix Organization
Bone Mineralization
Central Nervous System Myelin Formation
Multicellular Organism Growth
Hair Cell Differentiation
Embryonic Cleavage
Ribosomal Small Subunit Biogenesis
Erythrocyte Maturation
Skin Development
Positive Regulation Of Mitotic Recombination
Insulin-like Growth Factor Receptor Signaling Pathway
Embryonic Organ Development
Hair Follicle Maturation
Hematopoietic Stem Cell Differentiation
Hematopoietic Stem Cell Proliferation
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Regulation Of Mitotic Cell Cycle Phase Transition
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair, AP Site Formation
Nucleotide-excision Repair
DNA Recombination
DNA Damage Response
Response To UV
Response To UV-C
Negative Regulation Of Apoptotic Process
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
Cytosolic iron-sulfur cluster assembly
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Lung Cancer (DNA repair capacity) (
23108145
)
Sleep (1/2-day periodicity) (
33075057
)
Apolipoprotein A1 levels (
32203549
)
Metabolite levels (
23823483
)
Urinary calcium excretion (
31993563
)
Interacting Genes
16 interacting genes:
AR
CDK1
CDK7
ERCC3
ERCC5
GTF2E1
GTF2H1
GTF2H2
GTF2H2C_2
GTF2H3
HERC5
MTDH
RAD51
RAD52
TP53
TRIM25
12 interacting genes:
BRCA1
BRCA2
ERCC2
ERCC6
EWSR1
GTF2H1
GTF2H4
HSPB1
NTHL1
PCNA
POLR2A
RAD51
Entrez ID
2068
2073
HPRD ID
00530
00595
Ensembl ID
ENSG00000104884
ENSG00000134899
Uniprot IDs
P18074
P28715
PDB IDs
5IVW
5IY6
5IY7
5IY8
5IY9
5OF4
6NMI
6O9L
6O9M
6RO4
6TUN
7AD8
7EGB
7EGC
7ENA
7ENC
7LBM
7NVR
7NVW
7NVX
7NVY
7NVZ
7NW0
8BVW
8BYQ
8EBS
8EBT
8EBU
8EBV
8EBW
8EBX
8EBY
8GXQ
8GXS
8WAK
8WAL
8WAN
8WAO
8WAP
8WAQ
8WAR
8WAS
5EKF
5EKG
6TUR
6TUS
6TUW
6TUX
6VBH
Enriched GO Terms of Interacting Partners
?
Transcription Factor TFIIH Core Complex
Transcription Factor TFIIH Holo Complex
Nucleotide-excision Repair
DNA Repair
DNA-templated Transcription
DNA Metabolic Process
DNA Damage Response
Nucleic Acid Metabolic Process
Cellular Response To Stress
Nucleobase-containing Compound Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Transcription Initiation At RNA Polymerase II Promoter
Transcription By RNA Polymerase II
Macromolecule Biosynthetic Process
DNA-templated Transcription Initiation
Transcription Factor TFIID Complex
RNA Metabolic Process
Macromolecule Metabolic Process
Response To Stress
Nucleoplasm
Core TFIIH Complex Portion Of Holo TFIIH Complex
Nucleus
RNA Polymerase II General Transcription Initiation Factor Activity
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Recombinase Assembly
Response To UV
Response To Oxidative Stress
Regulation Of Primary Metabolic Process
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Response To Radiation
Regulation Of Cell Cycle Phase Transition
Double-strand Break Repair
Transcription-coupled Nucleotide-excision Repair
Chromatin Binding
Transcription Preinitiation Complex
Regulation Of Macromolecule Metabolic Process
Response To UV-C
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Single-stranded DNA Binding
Mitotic Recombination
Regulation Of Metabolic Process
Response To Light Stimulus
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of RNA Metabolic Process
Chromosome Organization
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To X-ray
Cyclin-dependent Protein Serine/threonine Kinase Activity
Nucleotide-excision Repair
DNA Repair
DNA Metabolic Process
DNA Damage Response
Nuclear Ubiquitin Ligase Complex
Nucleic Acid Metabolic Process
Transcription Factor TFIIH Core Complex
Cellular Response To Stress
Transcription Factor TFIIH Holo Complex
Damaged DNA Binding
Lateral Element
Response To Radiation
Nucleobase-containing Compound Metabolic Process
Regulation Of DNA Damage Checkpoint
Mitotic Recombination-dependent Replication Fork Processing
Response To X-ray
Nucleoplasm
Transcription By RNA Polymerase II
Response To Stress
Response To Ionizing Radiation
Replication Fork Processing
Response To UV
Cellular Response To Radiation
Intrinsic Apoptotic Signaling Pathway
Male Germ Cell Nucleus
Response To Gamma Radiation
DNA-templated Transcription
DNA-templated Transcription Elongation
Nucleus
Regulation Of Cell Cycle Phase Transition
Transcription Elongation By RNA Polymerase I
Nucleobase-containing Compound Biosynthetic Process
Regulation Of DNA Metabolic Process
Double-strand Break Repair
Regulation Of DNA Repair
DNA Binding
Cellular Response To Ionizing Radiation
Regulation Of Cellular Response To Stress
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Transcription-coupled Nucleotide-excision Repair
Positive Regulation Of DNA Metabolic Process
DNA Repair Complex
Telomere Maintenance Via Recombination
Telomere Maintenance
Apoptotic Signaling Pathway
Response To Light Stimulus
Chromosome
ATP-dependent DNA Damage Sensor Activity
RNA Polymerase Binding
Mitotic Recombination
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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