ERCC2 and GTF2H2C_2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ERCC2	GTF2H2C_2
Description		ERCC excision repair 2, TFIIH core complex helicase subunit	GTF2H2 family member C, copy 2
Image			No pdb structure
GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Cytoplasm Spindle Cytosol Cytoskeleton CAK-ERCC2 Complex MMXD Complex	Transcription Factor TFIIH Core Complex Nucleus Transcription Factor TFIIH Holo Complex Nuclear Speck
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Isomerase Activity ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity 5'-3' DNA Helicase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Response To Hypoxia In Utero Embryonic Development Nucleobase-containing Compound Metabolic Process DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Apoptotic Process DNA Damage Response Response To Oxidative Stress Chromosome Segregation Determination Of Adult Lifespan Response To UV UV Protection Post-embryonic Development Spinal Cord Development Hair Cycle Process Extracellular Matrix Organization Bone Mineralization Central Nervous System Myelin Formation Multicellular Organism Growth Hair Cell Differentiation Embryonic Cleavage Ribosomal Small Subunit Biogenesis Erythrocyte Maturation Skin Development Positive Regulation Of Mitotic Recombination Insulin-like Growth Factor Receptor Signaling Pathway Embryonic Organ Development Hair Follicle Maturation Hematopoietic Stem Cell Differentiation Hematopoietic Stem Cell Proliferation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Mitotic Cell Cycle Phase Transition	DNA Repair Nucleotide-excision Repair DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript Cytosolic iron-sulfur cluster assembly NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Lung Cancer (DNA repair capacity) ( 23108145) Sleep (1/2-day periodicity) ( 33075057)
Interacting Genes		16 interacting genes: AR CDK1 CDK7 ERCC3 ERCC5 GTF2E1 GTF2H1 GTF2H2 GTF2H2C_2 GTF2H3 HERC5 MTDH RAD51 RAD52 TP53 TRIM25	3 interacting genes: DZIP3 ERCC2 SUV39H1
Entrez ID		2068	730394
HPRD ID		00530	19238
Ensembl ID		ENSG00000104884
Uniprot IDs		P18074	Q6P1K8
PDB IDs		5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4 6TUN 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Nucleotide-excision Repair DNA Repair DNA-templated Transcription DNA Metabolic Process DNA Damage Response Nucleic Acid Metabolic Process Cellular Response To Stress Nucleobase-containing Compound Biosynthetic Process Nucleobase-containing Compound Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Transcription By RNA Polymerase II Macromolecule Biosynthetic Process DNA-templated Transcription Initiation Transcription Factor TFIID Complex RNA Metabolic Process Macromolecule Metabolic Process Response To Stress Nucleoplasm Core TFIIH Complex Portion Of Holo TFIIH Complex Nucleus RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Nucleobase-containing Compound Metabolic Process DNA Recombinase Assembly Response To UV Response To Oxidative Stress Regulation Of Primary Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Response To Radiation Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Transcription-coupled Nucleotide-excision Repair Chromatin Binding Transcription Preinitiation Complex Regulation Of Macromolecule Metabolic Process Response To UV-C Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Single-stranded DNA Binding Mitotic Recombination Regulation Of Metabolic Process Response To Light Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To X-ray Cyclin-dependent Protein Serine/threonine Kinase Activity	Determination Of Adult Lifespan RRNA Metabolic Process MMXD Complex CAK-ERCC2 Complex Transcription Elongation By RNA Polymerase I RRNA Processing Response To Hypoxia Regulation Of Mitotic Recombination Response To Oxygen Levels Hair Follicle Maturation Central Nervous System Myelin Formation Response To Decreased Oxygen Levels Positive Regulation Of Mitotic Recombination Histone H3K9 Trimethyltransferase Activity RDNA Heterochromatin Formation ENoSc Complex RDNA Heterochromatin 5'-3' DNA Helicase Activity Histone H3K9me2 Methyltransferase Activity Embryonic Cleavage Regulation Of Transcription By Glucose Regulation Of DNA Metabolic Process UV Protection Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Transcription-coupled Nucleotide-excision Repair Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Nuclear Lamina Histone H3K9 Methyltransferase Activity Facultative Heterochromatin Formation Epigenetic Programming In The Zygotic Pronuclei Chromatin Silencing Complex Myelin Assembly Erythrocyte Maturation Hematopoietic Stem Cell Differentiation Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Hair Cell Differentiation Histone H3 Methyltransferase Activity Hematopoietic Stem Cell Proliferation Blastocyst Hatching S-adenosylmethionine-dependent Methyltransferase Activity Spinal Cord Development Transcription Factor TFIID Complex DNA Damage Response Insulin-like Growth Factor Receptor Signaling Pathway Epigenetic Programming Of Gene Expression Histone Methyltransferase Activity DNA Helicase Activity Polyubiquitin Modification-dependent Protein Binding Maturation Of SSU-rRNA
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