ERCC8 and UQCRQ

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		ERCC8	UQCRQ
Description		ERCC excision repair 8, CSA ubiquitin ligase complex subunit	ubiquinol-cytochrome c reductase complex III subunit VII
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Chromosome Nuclear Matrix Cul4A-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Perikaryon Cul4-RING E3 Ubiquitin Ligase Complex Site Of DNA Damage	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Single Strand Break Repair Protein Polyubiquitination DNA Repair Transcription-coupled Nucleotide-excision Repair DNA Damage Response Response To Oxidative Stress Response To UV Response To X-ray Response To Auditory Stimulus Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Repair Protein Autoubiquitination Regulation Of Transcription-coupled Nucleotide-excision Repair Double-strand Break Repair Via Classical Nonhomologous End Joining	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Subthalamus Development Pons Development Cerebellar Purkinje Cell Layer Development Hippocampus Development Thalamus Development Hypothalamus Development Pyramidal Neuron Development Midbrain Development Cellular Respiration
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	Respiratory electron transport Mitochondrial protein degradation Complex III assembly Complex III assembly
Drugs			2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases		Cockayne syndrome Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Asthma ( 31619474)
Interacting Genes		12 interacting genes: CAMK2D CBR1 CSNK2B DDB1 ERCC6 GTF2H2 POLR2A RBX1 TOP1 UQCRQ UVSSA XAB2	5 interacting genes: ERCC6 ERCC8 OPTN POLR2M UBC
Entrez ID		1161	27089
HPRD ID		07523	17941
Ensembl ID		ENSG00000049167	ENSG00000164405
Uniprot IDs		A0A0S2Z3L1 B3KPW7 B4DGZ9 Q13216	O14949
PDB IDs		4A11 6FCV 7OO3 7OOB 7OOP 7OPC 7OPD 8B3D 8B3F 8B3G 8B3I 8QH5 9BZ0 9ER2 9FD2	5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Response To UV DNA Metabolic Process Response To Radiation DNA-templated Transcription DNA Repair Response To Light Stimulus Site Of DNA Damage Base-excision Repair, AP Site Formation Via Deaminated Base Removal Cul4B-RING E3 Ubiquitin Ligase Complex DNA-templated Transcription Elongation DNA Damage Response Nucleobase-containing Compound Biosynthetic Process Nucleic Acid Metabolic Process Macromolecule Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Prp19 Complex Transcription By RNA Polymerase II Nucleoplasm Base-excision Repair, AP Site Formation Protein Modification Process Chromatin-protein Adaptor Activity Nucleobase-containing Compound Metabolic Process Cullin Family Protein Binding Cul4-RING E3 Ubiquitin Ligase Complex RNA Metabolic Process Macromolecule Biosynthetic Process Protein Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transcription Elongation By RNA Polymerase II Cellular Response To Stress Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Type I Interferon-mediated Signaling Pathway Response To Gamma Radiation Pons Development Subthalamus Development Protein Ubiquitination Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Interferon-mediated Signaling Pathway 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity S-nitrosoglutathione Reductase (NADPH) Activity Protein Modification By Small Protein Conjugation Chromosome Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Dense Fibrillar Component Generation Of Catalytic Spliceosome For First Transesterification Step RNA Polymerase Inhibitor Activity	Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Transcription-coupled Nucleotide-excision Repair Protein Ubiquitination Response To X-ray Protein Modification By Small Protein Conjugation Post-translational Protein Modification Site Of DNA Damage Nucleotide-excision Repair DNA-templated Transcription Elongation Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription-coupled Nucleotide-excision Repair Maintenance Of ER Location Regulation Of DNA Metabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Protein Modification Process Positive Regulation Of DNA Repair Response To Ionizing Radiation Response To UV Negative Regulation Of Receptor Recycling Type 2 Mitophagy Double-strand Break Repair Nucleotide-excision Repair Complex Regulation Of DNA Repair B-WICH Complex DNA Protection Transcription Elongation By RNA Polymerase I Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Response To Superoxide Response To Oxygen Radical Positive Regulation Of Xenophagy Histone H4K16 Acetyltransferase Activity Endoplasmic Reticulum Localization Transcription Elongation Factor Activity Nucleoplasm Pyrimidine Dimer Repair Golgi Ribbon Formation Histone H3K14 Acetyltransferase Activity Positive Regulation Of DNA Metabolic Process Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Transcription Preinitiation Complex Cul4A-RING E3 Ubiquitin Ligase Complex Response To Light Stimulus Protein Tag Activity Protein Tyrosine Kinase Activator Activity Response To Oxidative Stress Positive Regulation Of Transcription By RNA Polymerase III ATP-dependent DNA Damage Sensor Activity
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