ERCC8 and POLR2A

Number of citations of the paper that reports this interaction (PubMedID 34526721)
65

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		ERCC8	POLR2A
Description		ERCC excision repair 8, CSA ubiquitin ligase complex subunit	RNA polymerase II subunit A
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Chromosome Nuclear Matrix Cul4A-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Perikaryon Cul4-RING E3 Ubiquitin Ligase Complex Site Of DNA Damage	DNA-directed RNA Polymerase Complex Prp19 Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex Chromosome Nucleolus Cytoplasm
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Magnesium Ion Binding Nucleic Acid Binding DNA Binding RNA Binding DNA-directed RNA Polymerase Activity RNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Kinase Binding Ubiquitin Protein Ligase Binding 5'-3' RNA Polymerase Activity Metal Ion Binding Microfibril Binding Promoter-specific Chromatin Binding
	Biological Process	Single Strand Break Repair Protein Polyubiquitination DNA Repair Transcription-coupled Nucleotide-excision Repair DNA Damage Response Response To Oxidative Stress Response To UV Response To X-ray Response To Auditory Stimulus Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Repair Protein Autoubiquitination Regulation Of Transcription-coupled Nucleotide-excision Repair Double-strand Break Repair Via Classical Nonhomologous End Joining	RNA-templated Transcription DNA-templated Transcription DNA-templated Transcription Termination Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Positive Regulation Of Gene Expression Positive Regulation Of RNA Splicing MRNA Transcription By RNA Polymerase II
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases		Cockayne syndrome Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Atrial fibrillation ( 29892015) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 29760442) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Myopia ( 27182965) Parkinson's disease progression (cognitive) ( 33958783) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		12 interacting genes: CAMK2D CBR1 CSNK2B DDB1 ERCC6 GTF2H2 POLR2A RBX1 TOP1 UQCRQ UVSSA XAB2	103 interacting genes: ABL1 ACTB ACTL6A ATM BARD1 BRCA1 CALCOCO1 CALCOCO2 CASP10 CCNH CCNK CCNL2 CCNT1 CDC14A CDK12 CDK8 CDK9 CPSF1 CPSF2 CPSF3 CREBBP CSH2 CSNK2A1 CSTF1 CSTF2 CTCF CTDP1 CTDSP1 CTDSP2 DHX9 EIF4ENIF1 ELL ERCC5 ERCC6 ERCC8 ERG ESR1 FUS GRB2 GTF2B GTF2H4 H1-2 HNRNPF HTATSF1 IFTAP ITCH IWS1 KAT2B KLK2 KMT2D LEO1 MCM3 MED21 MNAT1 MYH6 NEDD4 NONO NR0B2 NSD1 OTUD5 PCIF1 PHF8 PIN1 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2L PPIG PPP1CA PPP2CA PQBP1 PRMT5 PRPF19 PTEN RNF10 SAFB SKP2 SMN1 SMN2 SMURF1 SNAR-B2 SND1 SUB1 SUMO2 SUPT5H TAF10 TCEA1 TCERG1 TDRD3 TRAK1 TRAM2 TTK U2AF2 UBE2L3 UPF1 VDR XAB2 XRCC5 ZC3H4 ZNF74
Entrez ID		1161	5430
HPRD ID		07523	08916
Ensembl ID		ENSG00000049167	ENSG00000181222
Uniprot IDs		A0A0S2Z3L1 B3KPW7 B4DGZ9 Q13216	A0AAG2TJB2 P24928
PDB IDs		4A11 6FCV 7OO3 7OOB 7OOP 7OPC 7OPD 8B3D 8B3F 8B3G 8B3I 8QH5 9BZ0 9ER2 9FD2	2GHQ 2GHT 2LTO 3D9K 3D9L 3D9M 3D9N 3D9O 3D9P 4JXT 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5M3H 5M3J 6DRD 6F5P 6G0R 6IC8 6IC9 6O9L 6Q5Y 6XKB 6XRE 7EGB 7EGC 7LBM 7YCX 7Z1K 7Z42 8PM0 8PNP 8PNQ 8R3K 8R3L 8R60 8R65 9B9L 9EHZ 9EI1 9EI2 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Response To UV DNA Metabolic Process Response To Radiation DNA-templated Transcription DNA Repair Response To Light Stimulus Site Of DNA Damage Base-excision Repair, AP Site Formation Via Deaminated Base Removal Cul4B-RING E3 Ubiquitin Ligase Complex DNA-templated Transcription Elongation DNA Damage Response Nucleobase-containing Compound Biosynthetic Process Nucleic Acid Metabolic Process Macromolecule Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Prp19 Complex Transcription By RNA Polymerase II Nucleoplasm Base-excision Repair, AP Site Formation Protein Modification Process Chromatin-protein Adaptor Activity Nucleobase-containing Compound Metabolic Process Cullin Family Protein Binding Cul4-RING E3 Ubiquitin Ligase Complex RNA Metabolic Process Macromolecule Biosynthetic Process Protein Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transcription Elongation By RNA Polymerase II Cellular Response To Stress Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Type I Interferon-mediated Signaling Pathway Response To Gamma Radiation Pons Development Subthalamus Development Protein Ubiquitination Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Interferon-mediated Signaling Pathway 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity S-nitrosoglutathione Reductase (NADPH) Activity Protein Modification By Small Protein Conjugation Chromosome Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Dense Fibrillar Component Generation Of Catalytic Spliceosome For First Transesterification Step RNA Polymerase Inhibitor Activity	Nucleoplasm Nucleic Acid Metabolic Process Nucleus RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Elongation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of DNA Metabolic Process DNA Repair Regulation Of Cell Cycle Regulation Of DNA Repair DNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II MRNA Processing RNA Polymerase II, Core Complex DNA Damage Response Transcription Elongation By RNA Polymerase II Chromatin Binding Regulation Of Cell Cycle Process RNA Polymerase Binding Regulation Of Transcription Elongation By RNA Polymerase II Chromatin Organization Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle
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