GRM4 and GNA15

Number of citations of the paper that reports this interaction (PMID 8863838)
8

Data Source:
HPRD (in vivo)

		GRM4	GNA15
Gene Name		glutamate receptor, metabotropic 4	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Presynaptic Membrane Terminal Bouton Dendritic Shaft Presynaptic Active Zone Membrane	Heterotrimeric G-protein Complex Plasma Membrane
	Molecular Function	Group III Metabotropic Glutamate Receptor Activity G-protein Coupled Receptor Activity Calmodulin Binding Glutamate Receptor Activity Calcium-dependent Protein Binding	G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Neurotransmitter Secretion Learning Positive Regulation Of MAPK Cascade Regulation Of Neuron Apoptotic Process Regulation Of Synaptic Transmission, Glutamatergic	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Blood Coagulation Platelet Activation Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)	G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs		L-Glutamic Acid
Diseases
GWAS		Osteosarcoma ( 23727862)	Heart failure ( 20445134)
Protein-Protein Interactions		4 interactors: CALM1 FLNA GNA15 GNAQ	19 interactors: ADRB2 ADRBK1 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1
Entrez ID		2914	2769
HPRD ID		04978	00760
Ensembl ID		ENSG00000124493	ENSG00000060558
Uniprot IDs		A1L4F9 B7ZLU9 Q14833	P30679
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Dopamine Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Blood Coagulation Hemostasis Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Body Fluid Levels Wound Healing Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Cell Activation Response To Wounding G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Regulation Of Intracellular Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Platelet Degranulation Protein Stabilization Regulation Of Protein Stability Negative Regulation Of Protein Metabolic Process Regulation Of Protein Import Into Nucleus Cell Surface Receptor Signaling Pathway Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Regulation Of Protein Localization To Nucleus Response To Stress Regulation Of Nucleocytoplasmic Transport Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Intracellular Protein Transport Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Catalytic Activity Negative Regulation Of Protein Phosphorylation Exocytosis Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Neuron Remodeling Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Transport Negative Regulation Of Phosphorylation Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity MRNA Transcription From RNA Polymerase II Promoter Detection Of Calcium Ion Regulation Of Melanocyte Differentiation Regulation Of Cell Communication By Electrical Coupling Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Phosphoprotein Phosphatase Activity	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Defense Response Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Signaling Cell Communication Sensory Perception Of Pain Cellular Metal Ion Homeostasis Inflammatory Response Response To External Stimulus Opioid Receptor Signaling Pathway Cellular Cation Homeostasis Cellular Response To Stimulus Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Phosphorus Metabolic Process Cellular Chemical Homeostasis Blood Circulation Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Muscle Contraction Response To Stress Chemical Homeostasis Ion Homeostasis Synaptic Transmission Regulation Of Cyclase Activity Immune Response Regulation Of Phosphorylation Cytosolic Calcium Ion Homeostasis Regulation Of MAPK Cascade Regulation Of Catalytic Activity Homeostatic Process Regulation Of Signaling Interleukin-8-mediated Signaling Pathway Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Cellular Homeostasis Negative Regulation Of Muscle Contraction Negative Regulation Of Adenylate Cyclase Activity Regulation Of CAMP Biosynthetic Process Negative Regulation Of Lyase Activity Response To Stimulus Regulation Of CAMP Metabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Catalytic Activity
Tagcloud ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm3 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
Tagcloud (Difference) ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm3 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
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