GRM4

Gene Name		glutamate receptor, metabotropic 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Presynaptic Membrane Terminal Bouton Dendritic Shaft Presynaptic Active Zone Membrane
	Molecular Function	Group III Metabotropic Glutamate Receptor Activity G-protein Coupled Receptor Activity Calmodulin Binding Glutamate Receptor Activity Calcium-dependent Protein Binding
	Biological Process	Activation Of MAPK Activity Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Neurotransmitter Secretion Learning Positive Regulation Of MAPK Cascade Regulation Of Neuron Apoptotic Process Regulation Of Synaptic Transmission, Glutamatergic
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		L-Glutamic Acid
Diseases
GWAS		Osteosarcoma ( 23727862)
Protein-protein Interactions		4 interactors: CALM1 FLNA GNA15 GNAQ
Entrez ID		2914
HPRD ID		04978
Ensembl ID		ENSG00000124493
Uniprot IDs		A1L4F9 B7ZLU9 Q14833
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Dopamine Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Blood Coagulation Hemostasis Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Body Fluid Levels Wound Healing Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Cell Activation Response To Wounding G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Regulation Of Intracellular Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Platelet Degranulation Protein Stabilization Regulation Of Protein Stability Negative Regulation Of Protein Metabolic Process Regulation Of Protein Import Into Nucleus Cell Surface Receptor Signaling Pathway Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Regulation Of Protein Localization To Nucleus Response To Stress Regulation Of Nucleocytoplasmic Transport Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Intracellular Protein Transport Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Catalytic Activity Negative Regulation Of Protein Phosphorylation Exocytosis Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Neuron Remodeling Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Transport Negative Regulation Of Phosphorylation Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity MRNA Transcription From RNA Polymerase II Promoter Detection Of Calcium Ion Regulation Of Melanocyte Differentiation Regulation Of Cell Communication By Electrical Coupling Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Phosphoprotein Phosphatase Activity
Tagcloud ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm3 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi