WDTC1 and MED4

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
BioGRID (two hybrid)

		WDTC1	MED4
Description		WD and tetratricopeptide repeats 1	mediator complex subunit 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Histone Binding Histone Deacetylase Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Glucose Metabolic Process Regulation Of Cell Size Protein Ubiquitination Cellular Response To Insulin Stimulus Multicellular Organism Growth Negative Regulation Of Fatty Acid Biosynthetic Process Intracellular Chemical Homeostasis	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Neddylation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS			Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		3 interacting genes: DDB1 MED23 MED4	41 interacting genes: AMOT AP2M1 ATF7IP ATF7IP2 C1orf216 CCDC146 CCHCR1 CEBPA CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD GCC1 HAUS1 HGS IP6K3 ITSN1 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 OIP5 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 TLE5 TNFAIP8 TNFAIP8L1 USHBP1 WDTC1 WWP2
Entrez ID		23038	29079
HPRD ID		10307	16145
Ensembl ID		ENSG00000142784	ENSG00000136146
Uniprot IDs		Q8N5D0	Q9NPJ6
PDB IDs		3I7N	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA-templated Transcription, Elongation Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Mediator Complex Core Mediator Complex Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Protein-DNA Complex Assembly Positive Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of T Cell Extravasation Base-excision Repair, AP Site Formation Via Deaminated Base Removal WD40-repeat Domain Binding Cul4B-RING E3 Ubiquitin Ligase Complex Transcription Coactivator Activity Ubiquitin Ligase Complex Scaffold Activity Nucleic Acid Metabolic Process UV-damage Excision Repair Spindle Assembly Involved In Female Meiosis Cul4A-RING E3 Ubiquitin Ligase Complex Base-excision Repair, AP Site Formation Meiotic Spindle Assembly Cellular Component Assembly Epigenetic Programming In The Zygotic Pronuclei Positive Regulation Of Cellular Extravasation Nuclear Vitamin D Receptor Binding Ectopic Germ Cell Programmed Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Programmed Cell Death Involved In Cell Development Meiotic Spindle Organization Positive Regulation Of Gluconeogenesis Cullin Family Protein Binding Cul4-RING E3 Ubiquitin Ligase Complex Viral Release From Host Cell Nuclear Thyroid Hormone Receptor Binding Positive Regulation Of Viral Genome Replication Epigenetic Programming Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Migration Regulation Of Cellular Extravasation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Lymphocyte Migration Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Metabolic Process	Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Transcription Coregulator Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Modification Of Postsynaptic Structure Brahma Complex NBAF Complex RSC-type Complex NpBAF Complex Kinetochore Centrosome Regulation Of DNA-templated Transcription Initiation Regulation Of Exosomal Secretion Regulation Of Modification Of Synaptic Structure Nucleosome Disassembly Regulation Of Embryonic Development
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