LARP4 and YTHDF3

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		LARP4	YTHDF3
Description		La ribonucleoprotein 4	YTH N6-methyladenosine RNA binding protein F3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Cytosolic Small Ribosomal Subunit	P-body Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding	RNA Binding MRNA Binding Protein Binding Ribosome Binding N6-methyladenosine-containing RNA Reader Activity
	Biological Process	Translation Cytoskeleton Organization Post-transcriptional Regulation Of Gene Expression Regulation Of Cell Morphogenesis Positive Regulation Of Translation	Stress Granule Assembly Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Translational Initiation Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization Organelle Assembly Regulation Of Trophoblast Cell Migration
Pathways
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic widespread musculoskeletal pain ( 33331911) Pulse pressure ( 30578418)	Adult body size ( 32376654) Body size at age 10 ( 32376654) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Chronotype ( 30696823) HDL cholesterol levels ( 32203549) Myocardial infarction ( 26708285) Schizophrenia ( 33169155) Smoking behaviour (cigarettes smoked per day) ( 30679032) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549)
Interacting Genes		25 interacting genes: APP BCAS2 BHLHE40 CRX EXOSC7 FNDC3B KAT5 LENG1 LRRK2 LSM5 PAX5 PAX6 PCM1 PFDN5 POU6F2 PRC1 PRPF39 PRPF6 TGM5 TXNL4A WBP4 YPEL3 YTHDF3 ZC3H7A ZNF830	17 interacting genes: ALG13 ANKHD1 CPSF7 CTTN DMRTB1 EXOSC5 FAF1 LARP4 NMD3 PRRC2B QKI RBFOX2 RBM22 RPS21 SF1 SNRPA ZDHHC17
Entrez ID		113251	253943
HPRD ID		17289	08106
Ensembl ID		ENSG00000161813	ENSG00000185728
Uniprot IDs		Q6P4E2 Q71RC2 Q8TBL5 Q96J85	A0A024R7W5 A0A087WY31 B4DPX9 Q7Z739 Q8NA80
PDB IDs		2CQK 3PKN 6I9B	6ZOT 8BS5 8BS6
Enriched GO Terms of Interacting Partners?		Spliceosomal Complex RNA Splicing U2-type Precatalytic Spliceosome MRNA Processing RNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process U4/U6 X U5 Tri-snRNP Complex Cellular Response To Manganese Ion Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Manganese Ion Nucleus Retina Development In Camera-type Eye Golgi-associated Vesicle Regulation Of Amyloid Fibril Formation Cellular Response To Catecholamine Stimulus Cellular Component Assembly Response To Catecholamine U5 SnRNP Microtubule Cytoskeleton Organization Nucleoplasm Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Central Nervous System Development Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Microtubule-based Process Forebrain-midbrain Boundary Formation Pancreatic A Cell Development RNA Binding Establishment Of Mitotic Spindle Orientation RNA Polymerase III Assembly RNA Polymerase I Assembly Histone H2AK5 Acetyltransferase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly	RNA Binding Nucleic Acid Binding RNA Processing MRNA Metabolic Process MRNA Processing RNA Splicing RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA 3'-end Processing MRNA Cis Splicing, Via Spliceosome MRNA Binding Cytosolic Small Ribosomal Subunit Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nucleic Acid Metabolic Process Spliceosomal Complex Gamma-glutamyl-peptidase Activity Regulation Of RNA Splicing Internal N(7)-methylguanine-containing RNA Reader Activity Perforant Pathway To Dendrate Granule Cell Synapse Methionine Adenosyltransferase Regulator Activity N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Macromolecule Metabolic Process
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