GRIK3 and GRIK4

Number of citations of the paper that reports this interaction (PubMedID 29058671)
59

Data Source:
BioGRID (pull down)

		GRIK3	GRIK4
Description		glutamate ionotropic receptor kainate type subunit 3	glutamate ionotropic receptor kainate type subunit 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Plasma Membrane Membrane Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Glutamate-gated Receptor Activity Monoatomic Ion Channel Activity Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Regulation Of Presynaptic Membrane Potential	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Regulation Of Presynaptic Membrane Potential
Pathways		Activation of Ca-permeable Kainate Receptor Presynaptic function of Kainate receptors	Activation of Ca-permeable Kainate Receptor
Drugs		Glutamic acid Butabarbital Topiramate	Glutamic acid Butabarbital Topiramate
Diseases
GWAS		Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Forced expiratory volume in 1 second (environmental tobacco smoke interaction) ( 28738859) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Metabolite levels ( 23823483) Neuroticism ( 27067015) Post bronchodilator FEV1/FVC ratio ( 26634245) Schizophrenia ( 23894747)	Attention deficit hyperactivity disorder ( 23728934) Cognitive performance ( 20125193) Lateral ventricle volume ( 31530798) Post bronchodilator FEV1 in COPD ( 26634245)
Interacting Genes		4 interacting genes: FLNA GRIK1 GRIK4 GRIK5	4 interacting genes: GRIK1 GRIK2 GRIK3 RAB5A
Entrez ID		2899	2900
HPRD ID		00691	02613
Ensembl ID		ENSG00000163873	ENSG00000149403
Uniprot IDs		Q13003	A0A8D9PH79 A0A8D9UJ88 A6H8K8 B2RAP6 Q16099
PDB IDs
Enriched GO Terms of Interacting Partners?		Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Glutamate Receptor Signaling Pathway Regulation Of Membrane Potential Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Glutamate-gated Receptor Activity Presynaptic Membrane Monoatomic Ion Transmembrane Transport Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Monoatomic Ion Transport Postsynaptic Membrane Signaling Receptor Activity Regulation Of Presynaptic Membrane Potential Transmembrane Transport Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Hippocampal Mossy Fiber To CA3 Synapse Modulation Of Chemical Synaptic Transmission Cell-cell Signaling Cell Surface Receptor Signaling Pathway Signaling Cell Communication Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Biological Quality Synapse Fc-gamma Receptor I Complex Binding Tubulin Deacetylation Myb Complex Formation Of Radial Glial Scaffolds Establishment Of Sertoli Cell Barrier Glycoprotein Ib-IX-V Complex Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Protein Localization To Bicellular Tight Junction Cell Projection Regulation Of Cell Communication Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Signaling Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Blood Coagulation, Intrinsic Pathway Regulation Of Membrane Repolarization During Action Potential Glutamate-gated Calcium Ion Channel Activity Negative Regulation Of Transcription By RNA Polymerase I	Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Glutamate-gated Calcium Ion Channel Activity Glutamate-gated Receptor Activity Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Terminal Bouton Synaptic Transmission, Glutamatergic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Negative Regulation Of Synaptic Transmission, Glutamatergic Presynaptic Membrane Glutamate Receptor Activity Monoatomic Ion Channel Activity Calcium-mediated Signaling Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Postsynaptic Membrane Dendrite Cytoplasm Regulation Of Long-term Neuronal Synaptic Plasticity Signaling Receptor Activity Regulation Of Presynaptic Membrane Potential Chemical Synaptic Transmission Trans-synaptic Signaling Negative Regulation Of Synaptic Transmission Synaptic Signaling Axon Regulation Of Membrane Potential Regulation Of Neuronal Synaptic Plasticity Dendrite Cell-cell Signaling Cell Surface Receptor Signaling Pathway Signaling Cell Communication Mossy Fiber Rosette Detection Of Cold Stimulus Involved In Thermoception Extracellularly Glutamate-gated Ion Channel Activity Monoatomic Ion Transmembrane Transport Perikaryon Intracellular Signaling Cassette Regulation Of Biological Quality Monoatomic Ion Transport Synapse Protein Localization To Early Endosome Regulation Of Synaptic Plasticity Ionotropic Glutamate Receptor Complex
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