DCPS and CDC27

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DCPS	CDC27
Description		decapping enzyme, scavenger	cell division cycle 27
Image
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Spindle
	Molecular Function	RNA 7-methylguanosine Cap Binding RNA Exonuclease Activity Protein Binding Hydrolase Activity Identical Protein Binding 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity	Protein Binding Protein Phosphatase Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome MRNA Methylguanosine-cap Decapping	Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Neuron Projection Development Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		mRNA decay by 3' to 5' exoribonuclease	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs		7-methyl-GpppA 7-methyl-7,8-dihydroguanosine-5'-diphosphate 7-methyl-5'-guanylic acid 7-methyl-guanosine-5'-triphosphate-5'-guanosine 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine
Diseases
GWAS		Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494)	Body mass index ( 26426971) Diffusing capacity of carbon monoxide ( 30694715) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: CDC20 CDC27 CEBPA CHST4 CSNK2A2 FZR1 GPC5 KPNA2 KPNA5 KPNA6 YWHAQ	30 interacting genes: ADNP ANAPC1 ANAPC10 ANAPC2 ANAPC7 BUB1B CASP3 CDC16 CDC20 CDC26 CKS1B COMT CTNNB1 DCPS FZR1 GKN1 HOXC10 HSF2 MAD2L1 PABPC4 PIN1 PPP5C PTEN PTTG1 RB1 SKIL SMAD2 SMAD3 UBC UBE2S
Entrez ID		28960	996
HPRD ID		16787	00304
Ensembl ID		ENSG00000110063	ENSG00000004897
Uniprot IDs		A0A384MTI8 Q96C86	B4DL80 G5EA36 P30260
PDB IDs		1ST0 1ST4 1XML 1XMM 3BL7 3BL9 3BLA 4QDE 4QDV 4QEB 5OSY	3T1N 4RG6 4RG7 4RG9 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9FGQ 9GAW
Enriched GO Terms of Interacting Partners?		NLS-dependent Protein Nuclear Import Complex Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex NLS-bearing Protein Import Into Nucleus Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Viral Penetration Into Host Nucleus Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Meiotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle Intracellular Transport Of Virus Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Host Cell Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Activator Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Protein Import Into Nucleus Import Into Nucleus Regulation Of Protein Catabolic Process Regulation Of Chromosome Segregation Histone Deacetylase Binding Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Viral Life Cycle Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Meiotic Nuclear Division Protein Localization To Nucleus Regulation Of Reproductive Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Cell Cycle Nuclear Transport Nucleocytoplasmic Transport Animal Organ Regeneration Metaphase/anaphase Transition Of Meiosis I RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Nucleoplasm Positive Regulation Of Viral Process Regulation Of Cell Cycle Process Regulation Of Chromosome Separation	Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Mitotic Cell Cycle Protein K11-linked Ubiquitination Cell Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Protein Branched Polyubiquitination Regulation Of Sister Chromatid Segregation Regulation Of Reproductive Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Regulation Of Chromosome Segregation Regulation Of Nuclear Division Modification-dependent Protein Catabolic Process Nucleoplasm Regulation Of Chromosome Organization Protein Catabolic Process Proteasomal Protein Catabolic Process Metaphase/anaphase Transition Of Cell Cycle Proteolysis Involved In Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Binding Protein Polyubiquitination Regulation Of Mitotic Nuclear Division Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Chromosome Separation Ubiquitin Ligase Activator Activity Protein Ubiquitination Post-translational Protein Modification Regulation Of Mitotic Metaphase/anaphase Transition Protein Modification By Small Protein Conjugation Mitotic Checkpoint Complex Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Modification Process Catabolic Process Protein K48-linked Ubiquitination Proteolysis Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Cytosol Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Chromosome Separation Cell Cycle Phase Transition
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