DCPS and GPC5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DCPS	GPC5
Description		decapping enzyme, scavenger	glypican 5
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Extracellular Region Golgi Lumen Plasma Membrane Cell Surface Membrane Lysosomal Lumen Side Of Membrane
	Molecular Function	RNA 7-methylguanosine Cap Binding RNA Exonuclease Activity Protein Binding Hydrolase Activity Identical Protein Binding 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome MRNA Methylguanosine-cap Decapping	Regulation Of Signal Transduction Cell Migration Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Localization To Membrane
Pathways		mRNA decay by 3' to 5' exoribonuclease	Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Release of Hh-Np from the secreting cell Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs		7-methyl-GpppA 7-methyl-7,8-dihydroguanosine-5'-diphosphate 7-methyl-5'-guanylic acid 7-methyl-guanosine-5'-triphosphate-5'-guanosine 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine
Diseases
GWAS		Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494)	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Blood pressure (smoking interaction) ( 25189868) Blood protein levels ( 30072576) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 25429064 25282103 20189936 20881960) HIV-1 viral setpoint ( 20205591) Incident coronary heart disease ( 26950853) Interleukin-6 levels ( 33517400) Lung cancer ( 20304703) Metabolite levels ( 19043545 23823483) Multiple sclerosis ( 19010793) Nephrotic syndrome (acquired) ( 21441931) Neurological blood protein biomarker levels ( 31320639) Obesity-related traits ( 23251661) Rapid automised naming of letters ( 30741946) Refractive astigmatism ( 30306274) Rheumatoid arthritis ( 30423114) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Tetralogy of Fallot ( 23297363) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		11 interacting genes: CDC20 CDC27 CEBPA CHST4 CSNK2A2 FZR1 GPC5 KPNA2 KPNA5 KPNA6 YWHAQ	1 interacting genes: DCPS
Entrez ID		28960	2262
HPRD ID		16787	03902
Ensembl ID		ENSG00000110063	ENSG00000179399
Uniprot IDs		A0A384MTI8 Q96C86	P78333
PDB IDs		1ST0 1ST4 1XML 1XMM 3BL7 3BL9 3BLA 4QDE 4QDV 4QEB 5OSY
Enriched GO Terms of Interacting Partners?		NLS-dependent Protein Nuclear Import Complex Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex NLS-bearing Protein Import Into Nucleus Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Viral Penetration Into Host Nucleus Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Meiotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle Intracellular Transport Of Virus Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Host Cell Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Activator Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Protein Import Into Nucleus Import Into Nucleus Regulation Of Protein Catabolic Process Regulation Of Chromosome Segregation Histone Deacetylase Binding Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Viral Life Cycle Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Meiotic Nuclear Division Protein Localization To Nucleus Regulation Of Reproductive Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Cell Cycle Nuclear Transport Nucleocytoplasmic Transport Animal Organ Regeneration Metaphase/anaphase Transition Of Meiosis I RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Nucleoplasm Positive Regulation Of Viral Process Regulation Of Cell Cycle Process Regulation Of Chromosome Separation	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA 7-methylguanosine Cap Binding Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Methylguanosine-cap Decapping RNA Exonuclease Activity MRNA Cis Splicing, Via Spliceosome RNA Decapping RNA Destabilization Positive Regulation Of MRNA Catabolic Process MRNA Destabilization P-body Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability RNA Catabolic Process RNA Splicing, Via Transesterification Reactions
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