ANK3 and MBL2

		ANK3	MBL2
Description		ankyrin 3	mannose binding lectin 2
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Basal Plasma Membrane Cell Surface Intercalated Disc Spectrin-associated Cytoskeleton Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Sarcoplasmic Reticulum Z Disc T-tubule Axon Dendrite Neuromuscular Junction Node Of Ranvier Sarcolemma Cell Projection Neuron Projection Costamere Axon Initial Segment Organelle Synapse Postsynaptic Membrane	Extracellular Region Collagen Trimer Extracellular Space Multivesicular Body External Side Of Plasma Membrane Cell Surface Symbiont Cell Surface Serine-type Endopeptidase Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Cytoskeletal Anchor Activity Sodium Channel Regulator Activity Spectrin Binding Protein-macromolecule Adaptor Activity Transmembrane Transporter Binding Cadherin Binding Channel Activator Activity	Signaling Receptor Binding Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Identical Protein Binding Calcium-dependent Protein Binding
	Biological Process	Mitotic Cytokinesis Plasma Membrane Organization Cytoskeleton Organization Signal Transduction Axonogenesis Neuromuscular Junction Development Positive Regulation Of Gene Expression Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Sodium Ion Transport Magnesium Ion Homeostasis Neuronal Action Potential Positive Regulation Of Homotypic Cell-cell Adhesion Golgi To Plasma Membrane Protein Transport Regulation Of Potassium Ion Transport Establishment Of Protein Localization Positive Regulation Of Membrane Potential Golgi Vesicle Transport Cellular Response To Magnesium Ion Membrane Assembly Protein Localization To Plasma Membrane Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Protein Localization To Axon Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Proteolysis Acute-phase Response Complement Activation Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Zymogen Activation Killing Of Cells Of Another Organism Defense Response To Bacterium Surfactant Homeostasis Innate Immune Response Negative Regulation Of Viral Process Positive Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Protein Maturation Killing By Host Of Symbiont Cells Antiviral Innate Immune Response Positive Regulation Of Opsonization
Pathways		Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins COPI-mediated anterograde transport Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	Lectin pathway of complement activation Initial triggering of complement SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs			O3-Sulfonylgalactose Methyl alpha-D-mannoside 4-(Hydrogen sulfate)-beta-D-galactopyranose Methyl beta-L-fucopyranoside N-acetyl-alpha-neuraminic acid alpha-L-methyl-fucose Alpha-Methyl-N-Acetyl-D-Glucosamine
Diseases			Tuberculosis Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency
GWAS		Adventurousness ( 30643258) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 33097823) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Behavioral disturbance or psychiatric symptoms and prion disease ( 25897833) Bipolar disorder ( 18711365 33263727 31043756 34002096 28072414 24618891 22182935 21926972 20351715) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Diastolic blood pressure ( 30224653) Frailty index ( 34431594) Heel bone mineral density ( 30598549) Height ( 31562340) Metabolite levels ( 23823483) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457) Psychotic experience ( 31553412) Refractive error ( 32231278) Schizophrenia ( 20185149) Third ventricle volume ( 31530798) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)	Age-related macular degeneration ( 23326517) Blood protein levels ( 30072576) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chin dimples ( 27182965) Emphysema imaging phenotypes ( 26030696) Femoral neck bone mineral density ( 29499414) Fractures ( 30158200 30598549) Heel bone mineral density ( 28869591 30598549) Lumbar spine bone mineral density ( 22504420 29499414) Metabolite levels ( 23823483) Monobrow ( 27182965) Rosacea symptom severity ( 29771307)
Interacting Genes		22 interacting genes: FADD FAS GABARAP HOOK1 KCNC1 MAP1LC3A MAP1LC3C MAPK6 NAB2 NEDD4 PIK3R1 PLEC RIPK4 RNF10 SCN1B SCN2A SCNN1B SMAD2 SMAD3 SPTBN4 SRPK2 YAP1	9 interacting genes: CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC UBQLN2
Entrez ID		288	4153
HPRD ID		02715	01107
Ensembl ID		ENSG00000151150	ENSG00000165471
Uniprot IDs		Q12955 Q8NAK2	P11226
PDB IDs		4O6X	1HUP
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Nitrogen Starvation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Phosphatidylethanolamine Binding Node Of Ranvier Paraxial Mesoderm Morphogenesis SMAD Protein Signal Transduction Autophagosome Signal Transduction Response To Nutrient Levels Protein-containing Complex Organization Mesoderm Morphogenesis CD95 Death-inducing Signaling Complex Pericardium Development Death-inducing Signaling Complex SMAD Protein Complex Trophoblast Cell Migration Sodium Channel Complex Phospholipid Binding Cellular Response To Nutrient Levels Heteromeric SMAD Protein Complex Ameboidal-type Cell Migration Sodium Channel Inhibitor Activity Autophagosome Maturation Necroptotic Signaling Pathway Phosphatase Binding Autophagosome Membrane Negative Regulation Of Programmed Cell Death Cytosol Embryonic Foregut Morphogenesis Mitophagy Mesenchyme Development Regulation Of Programmed Cell Death Autolysosome Nodal Signaling Pathway Co-SMAD Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Nucleocytoplasmic Transport Voltage-gated Sodium Channel Complex Primary MiRNA Processing Regulation Of Sodium Ion Transport Vacuole Organization Cellular Response To Starvation Motor Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Regulation Of Biological Quality Transforming Growth Factor Beta Receptor Binding Wound Healing Sodium Ion Transport	Complement Activation, Lectin Pathway Complement Activation Complement Component C1q Complex Binding Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Activation Of Immune Response Spectrin Binding Carbohydrate Binding Positive Regulation Of Immune System Process Response To Other Organism Zymogen Activation Calcium Ion Binding Cell Surface Amylin Receptor Complex 2 Calcitonin Family Receptor Activity Positive Regulation Of Calcium-mediated Signaling Amylin Receptor Complex 1 Calcitonin Binding Response To External Biotic Stimulus Positive Regulation Of Immune Response Humoral Immune Response Regulation Of Humoral Immune Response Plasma Membrane Raft Distribution Regulation Of Endocytosis Sarcoplasmic Reticulum Protein Maturation Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Location In Cell Maintenance Of Location Maintenance Of Protein Location In Plasma Membrane Amylin Receptor Complex 3 Calcitonin Receptor Activity Positive Regulation Of Phagocytosis Regulation Of Immune System Process Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex Calcium-dependent Protein Binding Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Complement Component C4b Binding Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Calcium-mediated Signaling ERAD Pathway Immune Effector Process Secretory Granule Membrane Regulation Of Phagocytosis Regulation Of Immune Response Positive Regulation Of Cell Communication By Electrical Coupling Cytoskeleton Organization Amylin Receptor 3 Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?