ANK3 and TACR2

		ANK3	TACR2
Description		ankyrin 3	tachykinin receptor 2
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GO Annotations	Cellular Component	Cytoplasm Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Basal Plasma Membrane Cell Surface Intercalated Disc Spectrin-associated Cytoskeleton Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Sarcoplasmic Reticulum Z Disc T-tubule Axon Dendrite Neuromuscular Junction Node Of Ranvier Sarcolemma Cell Projection Neuron Projection Costamere Axon Initial Segment Organelle Synapse Postsynaptic Membrane	Plasma Membrane Membrane Sperm Flagellum Sperm Head Sperm Midpiece
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Cytoskeletal Anchor Activity Sodium Channel Regulator Activity Spectrin Binding Protein-macromolecule Adaptor Activity Transmembrane Transporter Binding Cadherin Binding Channel Activator Activity	G Protein-coupled Receptor Activity Tachykinin Receptor Activity Protein Binding Substance K Receptor Activity
	Biological Process	Mitotic Cytokinesis Plasma Membrane Organization Cytoskeleton Organization Signal Transduction Axonogenesis Neuromuscular Junction Development Positive Regulation Of Gene Expression Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Sodium Ion Transport Magnesium Ion Homeostasis Neuronal Action Potential Positive Regulation Of Homotypic Cell-cell Adhesion Golgi To Plasma Membrane Protein Transport Regulation Of Potassium Ion Transport Establishment Of Protein Localization Positive Regulation Of Membrane Potential Golgi Vesicle Transport Cellular Response To Magnesium Ion Membrane Assembly Protein Localization To Plasma Membrane Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Protein Localization To Axon Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity	Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Positive Regulation Of Acetylcholine Secretion, Neurotransmission Intestine Smooth Muscle Contraction Negative Regulation Of Luteinizing Hormone Secretion Operant Conditioning Positive Regulation Of Vascular Permeability Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Smooth Muscle Contraction Response To Electrical Stimulus Prolactin Secretion Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility
Pathways		Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins COPI-mediated anterograde transport Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	Tachykinin receptors bind tachykinins G alpha (q) signalling events
Drugs			Saredutant
Diseases
GWAS		Adventurousness ( 30643258) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 33097823) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Behavioral disturbance or psychiatric symptoms and prion disease ( 25897833) Bipolar disorder ( 18711365 33263727 31043756 34002096 28072414 24618891 22182935 21926972 20351715) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Diastolic blood pressure ( 30224653) Frailty index ( 34431594) Heel bone mineral density ( 30598549) Height ( 31562340) Metabolite levels ( 23823483) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457) Psychotic experience ( 31553412) Refractive error ( 32231278) Schizophrenia ( 20185149) Third ventricle volume ( 31530798) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)
Interacting Genes		22 interacting genes: FADD FAS GABARAP HOOK1 KCNC1 MAP1LC3A MAP1LC3C MAPK6 NAB2 NEDD4 PIK3R1 PLEC RIPK4 RNF10 SCN1B SCN2A SCNN1B SMAD2 SMAD3 SPTBN4 SRPK2 YAP1	5 interacting genes: GPRASP1 MTDH TAC1 TAC3 TAC4
Entrez ID		288	6865
HPRD ID		02715	01207
Ensembl ID		ENSG00000151150	ENSG00000075073
Uniprot IDs		Q12955 Q8NAK2	P21452
PDB IDs		4O6X	7XWO
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Nitrogen Starvation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Phosphatidylethanolamine Binding Node Of Ranvier Paraxial Mesoderm Morphogenesis SMAD Protein Signal Transduction Autophagosome Signal Transduction Response To Nutrient Levels Protein-containing Complex Organization Mesoderm Morphogenesis CD95 Death-inducing Signaling Complex Pericardium Development Death-inducing Signaling Complex SMAD Protein Complex Trophoblast Cell Migration Sodium Channel Complex Phospholipid Binding Cellular Response To Nutrient Levels Heteromeric SMAD Protein Complex Ameboidal-type Cell Migration Sodium Channel Inhibitor Activity Autophagosome Maturation Necroptotic Signaling Pathway Phosphatase Binding Autophagosome Membrane Negative Regulation Of Programmed Cell Death Cytosol Embryonic Foregut Morphogenesis Mitophagy Mesenchyme Development Regulation Of Programmed Cell Death Autolysosome Nodal Signaling Pathway Co-SMAD Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Nucleocytoplasmic Transport Voltage-gated Sodium Channel Complex Primary MiRNA Processing Regulation Of Sodium Ion Transport Vacuole Organization Cellular Response To Starvation Motor Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Regulation Of Biological Quality Transforming Growth Factor Beta Receptor Binding Wound Healing Sodium Ion Transport	Substance K Receptor Binding Tachykinin Receptor Signaling Pathway Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Substance P Receptor Binding Neuromedin K Receptor Binding Regulation Of Cilium Movement Regulation Of Microtubule-based Movement Positive Regulation Of Sensory Perception Of Pain Positive Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Sensory Perception Of Pain Regulation Of Blood Pressure Detection Of Temperature Stimulus Involved In Sensory Perception Regulation Of Reproductive Process Negative Regulation Of Systemic Arterial Blood Pressure Detection Of Temperature Stimulus Regulation Of Microtubule-based Process Negative Regulation Of Blood Pressure Neuropeptide Signaling Pathway Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Protein Location In Plasma Membrane Regulation Of Nervous System Process Positive Regulation Of Cell Motility G Protein-coupled Receptor Catabolic Process Bicellular Tight Junction Positive Regulation Of Locomotion Detection Of Abiotic Stimulus Receptor Ligand Activity Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Corticosterone Secretion Detection Of Stimulus Involved In Sensory Perception Negative Regulation Of Sensory Perception Of Pain Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Temperature Stimulus Insemination Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential G Protein-coupled Receptor Signaling Pathway Cellular Response To Magnesium Ion Regulation Of Corticosterone Secretion Intercellular Canaliculus Channel Activator Activity Regulation Of Membrane Depolarization During Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Synaptic Transmission, Cholinergic Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Spectrin-associated Cytoskeleton Negative Regulation Of Voltage-gated Potassium Channel Activity Regulation Of Delayed Rectifier Potassium Channel Activity
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