AVPR1A and AVP

Number of citations: 0 (PubMedID 8106369)
Data Source: HPRD (in vivo)

		AVPR1A	AVP
Name		arginine vasopressin receptor 1A	arginine vasopressin
Structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Endocytic Vesicle	Extracellular Region Extracellular Space Cytosol Secretory Granule Dendrite Clathrin-coated Endocytic Vesicle Membrane Neuronal Dense Core Vesicle
	Molecular Function	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Kinase C Binding Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding V1A Vasopressin Receptor Binding	Protein Kinase Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity Protein Binding V1A Vasopressin Receptor Binding V1B Vasopressin Receptor Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Generation Of Precursor Metabolites And Energy Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Female Receptivity Grooming Behavior Blood Circulation Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Positive Regulation Of Glutamate Secretion Myotube Differentiation Calcium-mediated Signaling Telencephalon Development Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Cellular Response To Hormone Stimulus Social Behavior Cellular Response To Water Deprivation Maternal Behavior Sperm Ejaculation Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Response To Corticosterone Negative Regulation Of Transmission Of Nerve Impulse Transport Across Blood-brain Barrier	Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Generation Of Precursor Metabolites And Energy Water Transport Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Female Receptivity Grooming Behavior Locomotory Behavior Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Salt Stress Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Multicellular Organismal Response To Stress Response To Testosterone Response To Nicotine Social Behavior Intracellular Signal Transduction Vasoconstriction Maternal Behavior Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Multicellular Organismal-level Water Homeostasis Response To Electrical Stimulus Negative Regulation Of Transmission Of Nerve Impulse Renal Water Absorption Blood Vessel Diameter Maintenance Response To Peptide Response To 2,3,7,8-tetrachlorodibenzodioxine Response To Nerve Growth Factor
Pathways		Vasopressin-like receptors G alpha (q) signalling events Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)	BMAL1:CLOCK,NPAS2 activates circadian expression Vasopressin-like receptors G alpha (q) signalling events G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) Organic anion transport by SLCO transporters Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)
Drugs		Desmopressin Vasopressin Felypressin Conivaptan Terlipressin PH-284 Tolvaptan Atosiban Relcovaptan Lypressin Pecavaptan	None
Diseases		None	Neurohypophyseal diabetes insipidus (NPDI); Central Diabetes Insipidus
GWAS		Chronotype ( 30696823 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Hippocampal volume ( 29860282 ) Morning person ( 30696823 ) Type 2 diabetes ( 31049640 )	No GWAS studies recorded
Interacting Genes		3 interacting genes: AVP GRK5 PRKCA	9 interacting genes: AVPR1A AVPR1B AVPR2 CRYAB DLX2 KMT2A OXTR PRKAB2 TXNDC17
Entrez ID		552	551
HPRD ID		02894	01891
Ensembl ID		ENSG00000166148	ENSG00000101200
Uniprot IDs		P37288 X5D2B0	P01185 X5DQP6
PDB IDs		1YTV	7BB6 7BB7 7DW9 7KH0 7R0C
GO Terms Enriched among Interactors		Renal Absorption Protein Kinase Activity Response To Ethanol Positive Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Renal System Process V1B Vasopressin Receptor Binding Regulation Of G Protein-coupled Receptor Signaling Pathway V1A Vasopressin Receptor Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Female Receptivity Neurohypophyseal Hormone Activity Response To Ketone Response To Alcohol Maternal Aggressive Behavior Beta-adrenergic Receptor Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Protein Kinase C Signaling Positive Regulation Of Cellular PH Reduction Regulation Of Cell Population Proliferation Positive Regulation Of Secretion By Cell Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Secretion Renal Water Absorption Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Female Receptivity Renal Water Transport Female Mating Behavior Aggressive Behavior Response To 2,3,7,8-tetrachlorodibenzodioxine Tachykinin Receptor Signaling Pathway Protein Phosphorylation G Protein-coupled Receptor Kinase Activity Desmosome Assembly Phosphorylation Signaling Receptor Binding Positive Regulation Of Prostaglandin Biosynthetic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Positive Regulation Of Glutamate Secretion Mitotic Nuclear Membrane Disassembly	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Vasopressin Receptor Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Vasoconstriction Regulation Of Systemic Arterial Blood Pressure Regulation Of Vasoconstriction Positive Regulation Of Blood Pressure Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Pressure Regulation Of Blood Circulation Vascular Process In Circulatory System Circulatory System Process Cellular Response To Hormone Stimulus G Protein-coupled Receptor Activity System Process Positive Regulation Of Systemic Arterial Blood Pressure Telencephalon Development Signal Transduction Regulation Of System Process G Protein-coupled Peptide Receptor Activity Response To Hormone Protein Kinase C Binding Positive Regulation Of Metabolic Process G Protein-coupled Receptor Signaling Pathway Renal Water Retention Oxytocin Receptor Activity Endocytic Vesicle Regulation Of Biological Quality Transport Across Blood-brain Barrier Positive Regulation Of Multicellular Organismal Process V1A Vasopressin Receptor Binding Cerebral Cortex GABAergic Interneuron Fate Commitment Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Cellular Response To Water Deprivation Response To Water Deprivation Sperm Ejaculation Negative Regulation Of Female Receptivity Maternal Aggressive Behavior Subpallium Development Positive Regulation Of Amacrine Cell Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Protein-disulfide Reductase [NAD(P)H] Activity Positive Regulation Of Cellular PH Reduction Positive Regulation Of Arachidonate Secretion Negative Regulation Of Urine Volume