LINC00632 and TPM1

Number of citations of the paper that reports this interaction (PubMedID 36527092)
63

Data Source:
BioGRID (unspecified method)

		LINC00632	TPM1
Description		long intergenic non-protein coding RNA 632	tropomyosin 1
Image		No pdb structure
GO Annotations	Cellular Component		Stress Fiber Cytoplasm Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Sarcomere Bleb Ruffle Membrane
	Molecular Function		Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding
	Biological Process		Positive Regulation Of Heart Rate By Epinephrine Regulation Of Muscle Contraction Cytoskeleton Organization Actin Filament Organization Regulation Of Heart Contraction Regulation Of Cell Shape Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways			Striated Muscle Contraction Smooth Muscle Contraction
Drugs			Artenimol Phenethyl Isothiocyanate
Diseases			Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM)
GWAS			Apolipoprotein A1 levels ( 32203549) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31451708) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin ( 32888494) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mean platelet volume ( 27863252 32888494 19820697) Orofacial clefts ( 22863734) Parkinson's disease ( 32201043) Parkinson's disease (familial, age at onset) ( 27402877) Platelet count ( 32888494 22139419 27863252) Platelet distribution width ( 27863252 32888494) Pulse pressure ( 27841878) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		37 interacting genes: ACO2 ACTR2 ANP32A ANXA6 ARF3 ASPH CTSB DYNC1LI2 ELAVL1 GDI1 GDI2 GNB1 HSPE1 ITGA3 LAP3 LGALS3 LMAN1 MDH2 MXRA7 PAICS PFKP PGD PGRMC1 PGRMC2 PSMA1 PXN RAB1B RECQL RPLP0 RPN2 RRAS2 SF1 STMN1 TGFBI TPM1 TUBA1C UGDH	31 interacting genes: ACTB BLOC1S6 C1orf216 CAGE1 CCHCR1 CDC42 CLIP4 EGFR EPB41 FGA GOLGA2 H19 IFIT3 JUN KXD1 LINC00632 MAD1L1 MAST2 NEB NOD2 PKD2 PSMC5 S100A2 SNAPIN TFPT TMOD2 TNNT1 TNNT2 TPM2 WASHC1 YEATS4
Entrez ID		286411	7168
HPRD ID			01839
Ensembl ID		ENSG00000203930	ENSG00000140416
Uniprot IDs			A0A0K0K1I0 A0A0S2Z4G6 A0A494BZZ2 B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H0YK48 H0YKJ4 H7BYY1 O15513 P09493 Q6ZN40
PDB IDs			3MUD 5KHT 6UT2 6X5Z 7UTI 7UTL 8EFH 8EFI 8ENC 8ZB7
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Focal Adhesion Rab GDP-dissociation Inhibitor Activity	Cytoskeleton Organization Identical Protein Binding Mitotic Spindle Actin Filament Organization Actin Binding Tropomyosin Binding BLOC-1 Complex Organelle Transport Along Microtubule Supramolecular Fiber Organization Cytoskeleton Actin Cytoskeleton Organization Actomyosin Structure Organization Organelle Organization Actin Filament-based Process Troponin Complex Regulation Of Lysosome Size BORC Complex Positive Regulation Of DNA Repair Response To Calcium Ion Striated Muscle Thin Filament Microvesicle Regulation Of Endosome Size General Transcription Initiation Factor Binding Positive Regulation Of Pseudopodium Assembly Cytoplasmic Side Of Lysosomal Membrane Transport Along Microtubule Eyelid Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Cycle Positive Regulation Of Epithelial Cell Proliferation Cytoskeleton-dependent Intracellular Transport Actin Filament Binding Muscle Contraction Anterograde Synaptic Vesicle Transport Regulation Of Vesicle Size Microtubule-based Transport Structural Constituent Of Cytoskeleton Regulation Of DNA Repair System Process Regulation Of Programmed Cell Death Embryonic Placenta Development Basolateral Plasma Membrane Host-mediated Perturbation Of Symbiont Process NuA4 Histone Acetyltransferase Complex Regulation Of Cellular Component Size Muscle System Process Cortical Cytoskeleton Blood Microparticle Positive Regulation Of DNA Metabolic Process Positive Regulation Of Norepinephrine Uptake
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