BRICD5 and MRM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BRICD5	MRM1
Description		BRICHOS domain containing 5	mitochondrial rRNA methyltransferase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding	RNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity RRNA (guanine) Methyltransferase Activity Transferase Activity RRNA (guanosine-2'-O-)-methyltransferase Activity
	Biological Process	Regulation Of Cell Population Proliferation	RRNA Modification RRNA 2'-O-methylation RRNA Processing RNA Processing RRNA Methylation Methylation
Pathways			rRNA modification in the mitochondrion
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Body mass index ( 26426971) Carotid intima media thickness x smoking interaction ( 32117412)
Interacting Genes		39 interacting genes: AQP6 ARL13B BIK CD69 CD79A CLEC2D CLRN1 CREB3L1 FKBP7 HHLA2 HSD17B13 ICAM3 IFNGR2 IFNLR1 KIR2DL3 KLRC1 LMNA LRRC25 LRRC4C MRM1 MTIF3 MUC1 NEMP1 PLEKHO1 PSCA PVR SCN3B SGPL1 SIGLEC9 SLAMF6 SLC18A1 SLC18A2 SORT1 SYNE4 TMEM234 TMEM248 TMEM79 TMPRSS2 TMX2	42 interacting genes: ADIPOQ AGTRAP AQP1 AQP2 AQP3 BRICD5 CCL4 CCL4L2 CDC42 CMTM3 CMTM5 CNIH1 COQ8A DNAJC30 EEF1A1 ERG28 ESRRG FKBP7 ITGAM KLRG1 LPAR3 MAL2 MESD MGST3 NRM NXPE3 RHBDD2 RNASE10 SELENOK SPX STATH STX7 SYP SYT3 TMEM11 TMEM243 TMEM42 TMEM97 TRARG1 TTPA VKORC1L1 VSTM1
Entrez ID		283870	79922
HPRD ID		14482	08656
Ensembl ID		ENSG00000182685	ENSG00000278619
Uniprot IDs		Q6PL45	Q6IN84
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Aminergic Neurotransmitter Loading Into Synaptic Vesicle Serotonin:sodium:chloride Symporter Activity Monoamine:proton Antiporter Activity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Clathrin-sculpted Monoamine Transport Vesicle Membrane Positive Regulation Of Natural Killer Cell Mediated Immunity Neurotransmitter Loading Into Synaptic Vesicle External Side Of Plasma Membrane Serotonin Uptake Monoamine Transmembrane Transporter Activity Plasma Membrane Type III Interferon-mediated Signaling Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity Amine Transport Regulation Of Natural Killer Cell Mediated Immunity Serotonin Transport Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Trans-Golgi Network Transport Vesicle Carbohydrate Binding Protein Binding Neurotransmitter Reuptake Dopamine Transport	Polyol Transmembrane Transport Renal Water Transport Glycerol Transmembrane Transport Carbohydrate Transport Carbohydrate Transmembrane Transport Water Channel Activity Glycerol Transmembrane Transporter Activity Membrane Renal Water Homeostasis Cellular Response To Mercury Ion Water Transport Multicellular Organismal-level Water Homeostasis Water Transmembrane Transporter Activity Renal Water Absorption Fluid Transport Channel Activity Cytokine Activity Response To Mercury Ion Response To Bacterium Positive Regulation Of Monocyte Chemotactic Protein-1 Production
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