MRM1 and COQ8A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MRM1	COQ8A
Description		mitochondrial rRNA methyltransferase 1	coenzyme Q8A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Mitochondrion Membrane Extrinsic Component Of Mitochondrial Inner Membrane Mitochondrial Membrane
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity RRNA (guanine) Methyltransferase Activity Transferase Activity RRNA (guanosine-2'-O-)-methyltransferase Activity	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Kinase Activity Transferase Activity ADP Binding
	Biological Process	RRNA Modification RRNA 2'-O-methylation RRNA Processing RNA Processing RRNA Methylation Methylation	Protein Phosphorylation Ubiquinone Biosynthetic Process Phosphorylation
Pathways		rRNA modification in the mitochondrion	Ubiquinol biosynthesis
Drugs			Fostamatinib
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Coenzyme Q10 deficiency
GWAS		Body mass index ( 26426971) Carotid intima media thickness x smoking interaction ( 32117412)
Interacting Genes		42 interacting genes: ADIPOQ AGTRAP AQP1 AQP2 AQP3 BRICD5 CCL4 CCL4L2 CDC42 CMTM3 CMTM5 CNIH1 COQ8A DNAJC30 EEF1A1 ERG28 ESRRG FKBP7 ITGAM KLRG1 LPAR3 MAL2 MESD MGST3 NRM NXPE3 RHBDD2 RNASE10 SELENOK SPX STATH STX7 SYP SYT3 TMEM11 TMEM243 TMEM42 TMEM97 TRARG1 TTPA VKORC1L1 VSTM1	27 interacting genes: ABHD5 AGTRAP CCDC34 CMTM4 CMTM5 CMTM6 COQ9 DESI2 DTX2 JOSD2 LDAF1 MAL2 MRM1 MTIF3 ORMDL3 PBX3 RABAC1 REEP6 RPRM SH3GLB1 SMPD2 STX10 TFIP11 TMCO2 TMEM239 TPD52L2 UBC
Entrez ID		79922	56997
HPRD ID		08656	07375
Ensembl ID		ENSG00000278619	ENSG00000163050
Uniprot IDs		Q6IN84	Q8NI60
PDB IDs			4PED 5I35 7UDP 7UDQ
Enriched GO Terms of Interacting Partners?		Polyol Transmembrane Transport Renal Water Transport Glycerol Transmembrane Transport Carbohydrate Transport Carbohydrate Transmembrane Transport Water Channel Activity Glycerol Transmembrane Transporter Activity Membrane Renal Water Homeostasis Cellular Response To Mercury Ion Water Transport Multicellular Organismal-level Water Homeostasis Water Transmembrane Transporter Activity Renal Water Absorption Fluid Transport Channel Activity Cytokine Activity Response To Mercury Ion Response To Bacterium Positive Regulation Of Monocyte Chemotactic Protein-1 Production
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