MRM1 and SPX

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MRM1	SPX
Description		mitochondrial rRNA methyltransferase 1	spexin hormone
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Extracellular Region Extracellular Space Cytoplasm Transport Vesicle Dense Core Granule Cytoplasmic Vesicle
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity RRNA (guanine) Methyltransferase Activity Transferase Activity RRNA (guanosine-2'-O-)-methyltransferase Activity	Hormone Activity Neuropeptide Hormone Activity Protein Binding Type 2 Galanin Receptor Binding Type 3 Galanin Receptor Binding
	Biological Process	RRNA Modification RRNA 2'-O-methylation RRNA Processing RNA Processing RRNA Methylation Methylation	Positive Regulation Of Systemic Arterial Blood Pressure Signal Transduction Negative Regulation Of Heart Rate Negative Regulation Of Appetite Negative Regulation Of Renal Sodium Excretion Long-chain Fatty Acid Import Into Cell Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Sensory Perception Of Pain Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction
Pathways		rRNA modification in the mitochondrion
Drugs
Diseases
GWAS		Body mass index ( 26426971) Carotid intima media thickness x smoking interaction ( 32117412)
Interacting Genes		42 interacting genes: ADIPOQ AGTRAP AQP1 AQP2 AQP3 BRICD5 CCL4 CCL4L2 CDC42 CMTM3 CMTM5 CNIH1 COQ8A DNAJC30 EEF1A1 ERG28 ESRRG FKBP7 ITGAM KLRG1 LPAR3 MAL2 MESD MGST3 NRM NXPE3 RHBDD2 RNASE10 SELENOK SPX STATH STX7 SYP SYT3 TMEM11 TMEM243 TMEM42 TMEM97 TRARG1 TTPA VKORC1L1 VSTM1	2 interacting genes: APP MRM1
Entrez ID		79922	80763
HPRD ID		08656	14405
Ensembl ID		ENSG00000278619	ENSG00000134548
Uniprot IDs		Q6IN84	Q9BT56
PDB IDs			7XJL
Enriched GO Terms of Interacting Partners?		Polyol Transmembrane Transport Renal Water Transport Glycerol Transmembrane Transport Carbohydrate Transport Carbohydrate Transmembrane Transport Water Channel Activity Glycerol Transmembrane Transporter Activity Membrane Renal Water Homeostasis Cellular Response To Mercury Ion Water Transport Multicellular Organismal-level Water Homeostasis Water Transmembrane Transporter Activity Renal Water Absorption Fluid Transport Channel Activity Cytokine Activity Response To Mercury Ion Response To Bacterium Positive Regulation Of Monocyte Chemotactic Protein-1 Production	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization RRNA (guanine) Methyltransferase Activity RRNA 2'-O-methylation RRNA (guanosine-2'-O-)-methyltransferase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle
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