SIAH3 and PINK1

Number of citations of the paper that reports this interaction (PubMedID 36307912)
42

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		SIAH3	PINK1
Description		siah E3 ubiquitin protein ligase family member 3	PTEN induced kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Cytosol Cytoskeleton Membrane Axon Growth Cone Cell Body Perinuclear Region Of Cytoplasm Lewy Body Astrocyte Projection
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Magnesium Ion Binding Protease Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Peptidase Activator Activity Transferase Activity Kinase Binding Ubiquitin Protein Ligase Binding Protein Kinase B Binding Protein-containing Complex Binding Metal Ion Binding C3HC4-type RING Finger Domain Binding Protein Serine Kinase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Stability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Targeting To Mitochondrion	Autophagy Of Mitochondrion Mitophagy Regulation Of Oxidative Phosphorylation Response To Ischemia Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Response To Stress Response To Oxidative Stress Mitochondrion Organization Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Gene Expression Regulation Of Mitochondrion Organization Dopamine Secretion Macroautophagy Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Protein Ubiquitination Respiratory Electron Transport Chain Hemopoiesis Positive Regulation Of Cell Migration Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Dopamine Secretion Positive Regulation Of Catecholamine Secretion Cellular Response To Oxidative Stress Intracellular Signal Transduction TORC2 Signaling Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Catecholamine Secretion Protein Stabilization Establishment Of Localization In Cell Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Hypoxia Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Mitochondrial Fission Cellular Response To Toxic Substance Mitochondrion To Lysosome Vesicle-mediated Transport Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Mitophagy Regulation Of Synaptic Vesicle Transport Negative Regulation Of Autophagosome Assembly Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Positive Regulation Of Cristae Formation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Free Ubiquitin Chain Polymerization Cellular Response To Hydrogen Sulfide Positive Regulation Of Type 2 Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			PINK1-PRKN Mediated Mitophagy FOXO-mediated transcription of cell death genes
Drugs
Diseases			Parkinson's disease (PD)
GWAS		Circulating fibroblast growth factor 23 levels ( 30217807) Rate of ventricular enlargement ( 31711042)	Household income (MTAG) ( 31844048) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		2 interacting genes: KRTAP6-2 PINK1	23 interacting genes: APPL2 BAG2 BAG5 BCL2L1 CRLS1 DNM1L FBXO7 HSH2D MAP3K7 MARK2 NEAT1 PARK7 RNF31 SIAH1 SIAH3 SNCAIP SPATC1L TGM2 TOMM20 TOMM70 TRAF6 UBC UBE2M
Entrez ID		283514	65018
HPRD ID		14145	10514
Ensembl ID		ENSG00000215475	ENSG00000158828
Uniprot IDs		Q8IW03	Q9BXM7
PDB IDs			9EIH 9EII 9EIJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Free Ubiquitin Chain Polymerization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Synaptic Transmission, Dopaminergic Cellular Response To Hydrogen Sulfide Positive Regulation Of Cristae Formation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Cristae Formation Lewy Body Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide C3HC4-type RING Finger Domain Binding Negative Regulation Of Mitochondrial Fission Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Maintenance Of Protein Location In Mitochondrion Dopamine Secretion Regulation Of Synaptic Vesicle Transport Positive Regulation Of Dopamine Secretion Response To Hydrogen Sulfide Regulation Of Synaptic Transmission, Dopaminergic Catecholamine Secretion Positive Regulation Of Catecholamine Secretion Negative Regulation Of Autophagosome Assembly Positive Regulation Of Cellular Respiration Peptidase Activator Activity Positive Regulation Of Type 2 Mitophagy Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Mitophagy Cellular Response To Toxic Substance Astrocyte Projection Protein Kinase B Binding Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway TORC2 Signaling Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Dopamine Transport Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Mitochondrial Fission Regulation Of ATP Biosynthetic Process Regulation Of Oxidative Phosphorylation Regulation Of Cellular Response To Hypoxia Regulation Of Dopamine Secretion Positive Regulation Of Mitophagy Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Aerobic Respiration Regulation Of Mitochondrial Fission Monoamine Transport Regulation Of Response To Oxidative Stress	Ubiquitin Protein Ligase Binding Mitochondrion Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Identical Protein Binding Mitochondrial Outer Membrane Regulation Of Inclusion Body Assembly Regulation Of Protein Stability Linear Polyubiquitin Binding Protein Targeting To Mitochondrion Regulation Of Programmed Cell Death Ubiquitin Conjugating Enzyme Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrion Organization Ubiquitin-protein Transferase Activity Mitochondrion Targeting Sequence Binding Protein Localization To Mitochondrion Positive Regulation Of Defense Response Interleukin-17A-mediated Signaling Pathway Regulation Of Protein Targeting To Mitochondrion Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway TOM Complex Negative Regulation Of Intracellular Signal Transduction Regulation Of Autophagy Of Mitochondrion Interleukin-33-mediated Signaling Pathway Regulation Of Apoptotic Process Mitochondrial Outer Membrane Translocase Complex Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Positive Regulation Of Catabolic Process CD40 Signaling Pathway Positive Regulation Of Autophagy TRIF-dependent Toll-like Receptor Signaling Pathway CD40 Receptor Complex Regulation Of Mitochondrial Membrane Potential Regulation Of Intracellular Signal Transduction Protein Metabolic Process Positive Regulation Of JUN Kinase Activity Regulation Of Macroautophagy Regulation Of Protein Ubiquitination Establishment Of Protein Localization To Mitochondrion Protein Insertion Into Mitochondrial Outer Membrane Regulation Of Protein Localization Negative Regulation Of Protein Ubiquitination Regulation Of Cellular Component Organization Regulation Of Apoptotic Signaling Pathway Protein Modification Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
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