SIAH3 and KRTAP6-2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SIAH3	KRTAP6-2
Description		siah E3 ubiquitin protein ligase family member 3	keratin associated protein 6-2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion	Cytosol Intermediate Filament
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Identical Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Stability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Targeting To Mitochondrion	Keratinization
Pathways			Keratinization
Drugs
Diseases
GWAS		Circulating fibroblast growth factor 23 levels ( 30217807) Rate of ventricular enlargement ( 31711042)
Interacting Genes		2 interacting genes: KRTAP6-2 PINK1	186 interacting genes: ADAM12 ADAMTSL4 ANAPC11 ANKS1A ANXA11 APOBEC1 AQP1 ARID5A ATG9A ATN1 ATOSB ATPAF2 BEX2 BHLHE40 C10orf55 C1orf94 C6orf15 CAMK2A CAMK2B CASC3 CATSPER1 CCDC120 CCDC17 CCDC28A-AS1 CCER1 CCNK CELF5 CERCAM CERK CFP CHIC2 CIMIP1 CIMIP2B COL8A1 CREB5 CTRC CYSRT1 DAZAP2 DHRS1 DMRT3 ENKD1 ESR2 FAAP20 FAM168A FAM83A FOXD2 FOXD4L1 FOXD4L3 FOXP3 FRS3 GALT GATA3 GCM2 GLIS2 GLYCTK GNE GPS2 GRINA GRN GSTP1 HAPLN2 HELT HEY1 HEY2 HEYL HHEX HOXA1 HOXB9 HOXC8 HOXC9 HSF4 HYAL2 IGFN1 INCA1 INO80B ITGB4 KLHL38 KPRP KRT83 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP15-1 KRTAP19-5 KRTAP26-1 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP6-1 KRTAP6-3 LASP1 LCE2B LCE2D LCE5A LETM1 LGALS9C LRFN4 LRRC41 LYVE1 MEIS2 MGAT5B MKRN3 NAF1 NDUFA9 NEU4 NFKBID NID2 NPBWR2 NR1D2 NSD1 OLIG3 OTX1 OXER1 PATL1 PATZ1 PAX3 PDP1 PHLDA1 PITX1 PKD2 PLEKHN1 PLSCR4 POGZ POU5F2 PRR13 PRR3 PRR30 PRR35 RASD1 RBFOX2 RBPMS2 RERE RHOXF2 RNF38 ROR2 RTP5 RUNX1T1 RUSC1 SAMD7 SAXO4 SHARPIN SIAH3 SMAP2 SMARCC1 SMN1 SMN2 SMUG1 SNRPB SNRPC SPAG8 SPATA8 SPMIP9 TBX6 TCF7L2 TEKT3 TEKT4 TEKT5 TENT5B TENT5D TEPSIN TFAP2D TLE5 TLX2 TLX3 TNIP1 TOLLIP TPRX1 TRIP13 TSGA10IP TSPAN4 TSPYL6 VAC14 VENTX VGLL3 VPS37C YPEL3 ZBTB32 ZC3H10 ZIC1 ZNF414 ZNF503 ZNF581 ZNF683 ZNF843
Entrez ID		283514	337967
HPRD ID		14145	11219
Ensembl ID		ENSG00000215475	ENSG00000186930
Uniprot IDs		Q8IW03	Q3LI66
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Free Ubiquitin Chain Polymerization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Synaptic Transmission, Dopaminergic Cellular Response To Hydrogen Sulfide Positive Regulation Of Cristae Formation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Cristae Formation Lewy Body Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide C3HC4-type RING Finger Domain Binding Negative Regulation Of Mitochondrial Fission Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Maintenance Of Protein Location In Mitochondrion Dopamine Secretion Regulation Of Synaptic Vesicle Transport Positive Regulation Of Dopamine Secretion Response To Hydrogen Sulfide Regulation Of Synaptic Transmission, Dopaminergic Catecholamine Secretion Positive Regulation Of Catecholamine Secretion Negative Regulation Of Autophagosome Assembly Positive Regulation Of Cellular Respiration Peptidase Activator Activity Positive Regulation Of Type 2 Mitophagy Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Mitophagy Cellular Response To Toxic Substance Astrocyte Projection Protein Kinase B Binding Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway TORC2 Signaling Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Dopamine Transport Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Mitochondrial Fission Regulation Of ATP Biosynthetic Process Regulation Of Oxidative Phosphorylation Regulation Of Cellular Response To Hypoxia Regulation Of Dopamine Secretion Positive Regulation Of Mitophagy Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Aerobic Respiration Regulation Of Mitochondrial Fission Monoamine Transport Regulation Of Response To Oxidative Stress	Protein Binding Chromatin DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intermediate Filament Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Axonemal A Tubule Inner Sheath Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Keratin Filament Keratinization Regulation Of Gene Expression Anterior/posterior Pattern Specification Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Sperm Flagellum DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Corepressor Activity Positive Regulation Of Biosynthetic Process Umbilical Cord Morphogenesis Pattern Specification Process Identical Protein Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cardiac Ventricle Morphogenesis Flagellated Sperm Motility Sperm Motility Myoblast Fate Commitment Positive Regulation Of Macromolecule Metabolic Process Hair Cycle Cilium-dependent Cell Motility
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