SIAH3

Description		siah E3 ubiquitin protein ligase family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Stability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Targeting To Mitochondrion
Pathways
Drugs
Diseases
GWAS		Circulating fibroblast growth factor 23 levels ( 30217807) Rate of ventricular enlargement ( 31711042)
Interacting Genes		2 interacting genes: KRTAP6-2 PINK1
Entrez ID		283514
HPRD ID		14145
Ensembl ID		ENSG00000215475
Uniprot IDs		Q8IW03
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Free Ubiquitin Chain Polymerization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Synaptic Transmission, Dopaminergic Cellular Response To Hydrogen Sulfide Positive Regulation Of Cristae Formation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Cristae Formation Lewy Body Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide C3HC4-type RING Finger Domain Binding Negative Regulation Of Mitochondrial Fission Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Maintenance Of Protein Location In Mitochondrion Dopamine Secretion Regulation Of Synaptic Vesicle Transport Positive Regulation Of Dopamine Secretion Response To Hydrogen Sulfide Regulation Of Synaptic Transmission, Dopaminergic Catecholamine Secretion Positive Regulation Of Catecholamine Secretion Negative Regulation Of Autophagosome Assembly Positive Regulation Of Cellular Respiration Peptidase Activator Activity Positive Regulation Of Type 2 Mitophagy Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Mitophagy Cellular Response To Toxic Substance Astrocyte Projection Protein Kinase B Binding Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway TORC2 Signaling Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Dopamine Transport Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Mitochondrial Fission Regulation Of ATP Biosynthetic Process Regulation Of Oxidative Phosphorylation Regulation Of Cellular Response To Hypoxia Regulation Of Dopamine Secretion Positive Regulation Of Mitophagy Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Aerobic Respiration Regulation Of Mitochondrial Fission Monoamine Transport Regulation Of Response To Oxidative Stress
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