CD55 and GPLD1

Number of citations of the paper that reports this interaction (PubMedID 7512501)
57

Data Source:
HPRD (in vitro)

		CD55	GPLD1
Description		CD55 molecule (Cromer blood group)	glycosylphosphatidylinositol specific phospholipase D1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Plasma Membrane Cell Surface Membrane Transport Vesicle Secretory Granule Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Raft Extracellular Exosome Side Of Membrane Ficolin-1-rich Granule Membrane	Extracellular Region Extracellular Space Cytoplasm Lysosomal Membrane Extracellular Matrix Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Virus Receptor Activity Protein Binding Lipid Binding	Glycosylphosphatidylinositol Phospholipase D Activity Phospholipase D Activity Hydrolase Activity Sodium Channel Regulator Activity
	Biological Process	Immune System Process Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of T Cell Cytokine Production Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Complement Activation, Classical Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Complement Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response Respiratory Burst Negative Regulation Of Complement Activation Symbiont Entry Into Host Cell Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Ossification Cell Migration Involved In Sprouting Angiogenesis Chondrocyte Differentiation Complement Receptor Mediated Signaling Pathway Lipid Metabolic Process Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Protein Secretion Response To Glucose Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Triglyceride Catabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Cellular Response To Insulin Stimulus Hematopoietic Stem Cell Migration Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Apoptotic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Transepithelial Transport Cellular Response To Cholesterol Cellular Response To Triglyceride Cellular Response To Xenobiotic Stimulus Cellular Response To PH Hematopoietic Stem Cell Migration To Bone Marrow Regulation Of Cellular Response To Insulin Stimulus
Pathways		Class B/2 (Secretin family receptors) Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade	Post-translational modification: synthesis of GPI-anchored proteins
Drugs		Chloramphenicol
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Refractive error ( 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Serum alkaline phosphatase levels ( 29403010 31666285 33339817 33547301)
Interacting Genes		6 interacting genes: ADGRE5 CD14 CR1 FYN GPLD1 LCK	5 interacting genes: ALPP APOA1 APOA4 CD55 GM2A
Entrez ID		1604	2822
HPRD ID		00500	03946
Ensembl ID		ENSG00000196352	ENSG00000112293
Uniprot IDs		B1AP13 P08174	P80108
PDB IDs		1H03 1H04 1H2P 1H2Q 1M11 1NWV 1OJV 1OJW 1OJY 1OK1 1OK2 1OK3 1OK9 1UOT 1UPN 2C8I 2QZD 2QZF 2QZH 3IYP 3J24 5FOA 6ILJ 6ILK 6LA5 7C9W 7DO4 7VY5 7VY6 8B8R 8K9R 8K9T
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response CD8 Receptor Binding Positive Regulation Of Immune Response CD4 Receptor Binding Secretory Granule Membrane Phospholipase Activator Activity T Cell Receptor Binding Complement Receptor Mediated Signaling Pathway Regulation Of Immune Response Phosphatidylinositol 3-kinase Binding ATP Transport Positive Regulation Of Immune System Process Immune System Process Phospholipase Binding Cell Surface Receptor Signaling Pathway Membrane Raft Adenine Nucleotide Transport Purine Nucleotide Transport Fc-gamma Receptor Signaling Pathway Nucleotide Transport Regulation Of Regulatory T Cell Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of T Cell Activation T Cell Costimulation Positive Regulation Of Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Response To Xenobiotic Stimulus Regulation Of Immune System Process Fc Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Opsonin Receptor Activity Complement Component C3b Receptor Activity Positive Regulation Of Lymphocyte Activation Immune Complex Clearance By Erythrocytes Positive Regulation Of Cell-cell Adhesion Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity Cellular Response To Glycine Response To Singlet Oxygen Positive Regulation Of Alkaline Phosphatase Activity Glycosylphosphatidylinositol Phospholipase D Activity FMN Transmembrane Transporter Activity FAD Transmembrane Transporter Activity FAD Transmembrane Transport Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Carbohydrate Derivative Transport	Lipid Transporter Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Intestinal Cholesterol Absorption Chylomicron Regulation Of Intestinal Lipid Absorption Phospholipid Efflux Regulation Of Intestinal Absorption Low-density Lipoprotein Particle Reverse Cholesterol Transport Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Plasma Lipoprotein Particle Assembly Cholesterol Transfer Activity Protein-lipid Complex Assembly Cholesterol Efflux Lipoprotein Metabolic Process Lipid Storage Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Acylglycerol Homeostasis Lipid Transport Lipid Binding Phosphatidylcholine Metabolic Process Regulation Of Cholesterol Transport Cholesterol Transport Sterol Transport Phospholipid Transport Extracellular Vesicle Sterol Homeostasis Cholesterol Homeostasis Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity Cholesterol Metabolic Process Cell Surface Side Of Membrane Phospholipid Binding Sterol Metabolic Process Blood Microparticle Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Lipid Metabolic Process Organophosphate Ester Transport Regulation Of Lipid Transport Peptidyl-methionine Modification Positive Regulation Of Small Molecule Metabolic Process High-density Lipoprotein Particle Receptor Binding Organic Hydroxy Compound Transport Chylomicron Assembly Negative Regulation Of Plasma Lipoprotein Oxidation Response To Lipid Hydroperoxide
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