CD55 and ADGRE5

Number of citations of the paper that reports this interaction (PubMedID 10540231)
26

Data Source:
HPRD (in vivo)

		CD55	ADGRE5
Description		CD55 molecule (Cromer blood group)	adhesion G protein-coupled receptor E5
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Plasma Membrane Cell Surface Membrane Transport Vesicle Secretory Granule Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Raft Extracellular Exosome Side Of Membrane Ficolin-1-rich Granule Membrane	Extracellular Region Plasma Membrane Focal Adhesion Membrane Secretory Granule Membrane Extracellular Exosome
	Molecular Function	Virus Receptor Activity Protein Binding Lipid Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding Protein Binding
	Biological Process	Immune System Process Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of T Cell Cytokine Production Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Complement Activation, Classical Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Complement Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response Respiratory Burst Negative Regulation Of Complement Activation Symbiont Entry Into Host Cell Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Immune System Process Inflammatory Response Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling
Pathways		Class B/2 (Secretin family receptors) Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade	Class B/2 (Secretin family receptors) Neutrophil degranulation
Drugs		Chloramphenicol
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Refractive error ( 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		6 interacting genes: ADGRE5 CD14 CR1 FYN GPLD1 LCK	3 interacting genes: CD55 HNRNPD XRN1
Entrez ID		1604	976
HPRD ID		00500	03130
Ensembl ID		ENSG00000196352	ENSG00000123146
Uniprot IDs		B1AP13 P08174	P48960
PDB IDs		1H03 1H04 1H2P 1H2Q 1M11 1NWV 1OJV 1OJW 1OJY 1OK1 1OK2 1OK3 1OK9 1UOT 1UPN 2C8I 2QZD 2QZF 2QZH 3IYP 3J24 5FOA 6ILJ 6ILK 6LA5 7C9W 7DO4 7VY5 7VY6 8B8R 8K9R 8K9T	2BOU 7DO4 7YDH 7YDJ 7YDM 7YDP 8IKJ 8IKL
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response CD8 Receptor Binding Positive Regulation Of Immune Response CD4 Receptor Binding Secretory Granule Membrane Phospholipase Activator Activity T Cell Receptor Binding Complement Receptor Mediated Signaling Pathway Regulation Of Immune Response Phosphatidylinositol 3-kinase Binding ATP Transport Positive Regulation Of Immune System Process Immune System Process Phospholipase Binding Cell Surface Receptor Signaling Pathway Membrane Raft Adenine Nucleotide Transport Purine Nucleotide Transport Fc-gamma Receptor Signaling Pathway Nucleotide Transport Regulation Of Regulatory T Cell Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of T Cell Activation T Cell Costimulation Positive Regulation Of Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Response To Xenobiotic Stimulus Regulation Of Immune System Process Fc Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Opsonin Receptor Activity Complement Component C3b Receptor Activity Positive Regulation Of Lymphocyte Activation Immune Complex Clearance By Erythrocytes Positive Regulation Of Cell-cell Adhesion Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity Cellular Response To Glycine Response To Singlet Oxygen Positive Regulation Of Alkaline Phosphatase Activity Glycosylphosphatidylinositol Phospholipase D Activity FMN Transmembrane Transporter Activity FAD Transmembrane Transporter Activity FAD Transmembrane Transport Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Carbohydrate Derivative Transport	Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Hepatocyte Dedifferentiation Regulation Of Telomere Maintenance Cellular Response To Putrescine Regulation Of DNA Biosynthetic Process Cellular Response To Puromycin Cellular Response To Cycloheximide Circadian Regulation Of Translation Response To Rapamycin RNA Catabolic Process Positive Regulation Of Telomere Capping Cell Dedifferentiation MCRD-mediated MRNA Stability Complex Response To Ketone Regulation Of Chromosome Organization Response To Alcohol Response To Cycloheximide 5'-3' RNA Exonuclease Activity G-quadruplex RNA Binding Golgi Trans Cisterna Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding G-quadruplex DNA Binding Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Nucleobase-containing Compound Catabolic Process CRD-mediated MRNA Stabilization 5'-3' Exonuclease Activity Nuclear MRNA Surveillance Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Complement Activation Regulation Of Telomere Capping Regulation Of Translation Histone MRNA Catabolic Process Cellular Response To Nitric Oxide RRNA Catabolic Process Positive Regulation Of Cytoplasmic Translation 3'-UTR-mediated MRNA Destabilization Cellular Response To Reactive Nitrogen Species Regulation Of Complement Activation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Respiratory Burst Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of DNA Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Telomere Maintenance Via Telomerase Response To Salt Response To Nitric Oxide Response To Ether
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