GP9 and GP1BA

Number of citations: 0 (PubMedID 12693941)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		GP9	GP1BA
Name		glycoprotein IX platelet	glycoprotein Ib platelet subunit alpha
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Glycoprotein Ib-IX-V Complex	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Glycoprotein Ib-IX-V Complex
	Molecular Function	Protein Binding	Protein Binding Thrombin-activated Receptor Activity Signaling Receptor Activity
	Biological Process	Cell Adhesion Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Megakaryocyte Development Release Of Sequestered Calcium Ion Into Cytosol	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Platelet Activation Regulation Of Blood Coagulation Megakaryocyte Development Fibrinolysis Release Of Sequestered Calcium Ion Into Cytosol Thrombin-activated Receptor Signaling Pathway
Pathways		Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V	Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V
Drugs		Quinine	Ibuprofen Egaptivon pegol liposomal prostaglandin E1 Dexibuprofen
Diseases		Bernard-Soulier syndrome; Giant platelet syndrome	Bernard-Soulier syndrome; Giant platelet syndrome
GWAS		Mean platelet volume ( 32888494 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 )	Blood protein levels ( 30072576 ) Keratoconus ( 33649486 ) Mean platelet volume ( 27863252 32888494 ) Platelet count ( 20139978 22139419 27863252 29403010 32888494 ) Platelet distribution width ( 27863252 32888494 ) Plateletcrit ( 32888494 )
Novel Interactors		1 novel interactors: RAB7A	1 novel interactors: FBXL4
Interacting Genes		5 interacting genes: APPBP2 GP1BA GP1BB HOXA1 SPRY2	17 interacting genes: CTSG DDIT3 F11 F12 F2 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP PIK3R1 SELP TPST1 VWF YWHAZ
Entrez ID		2815	2811
HPRD ID		01432	01976
Ensembl ID		ENSG00000169704	ENSG00000185245
Uniprot IDs		P14770	L7UYB8 P07359
PDB IDs		3REZ 8WFS	1GWB 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6 6XFQ 8WE2 8WF6 8WFS
GO Terms Enriched among Interactors		Glycoprotein Ib-IX-V Complex Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Protein Activation Cascade Megakaryocyte Development Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Platelet Activation Negative Regulation Of Sequestering Of Calcium Ion Platelet Activation Myeloid Cell Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Semicircular Canal Formation Synaptic Vesicle Recycling Via Endosome Calcium Ion Transmembrane Import Into Cytosol Coagulation Blood Coagulation Hemostasis Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Lung Growth Regulation Of Sequestering Of Calcium Ion Sensory Perception Of Sound Lipophagy Sensory Perception Of Mechanical Stimulus Negative Regulation Of Exosomal Secretion Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Hemopoiesis Thrombin-activated Receptor Activity Protein To Membrane Docking Regulation Of Endosome Organization Ubiquitin-protein Transferase Inhibitor Activity Calcium Ion Transmembrane Transport Alveolar Lamellar Body Microtubule End Phagosome Acidification Bud Elongation Involved In Lung Branching Embryonic Neurocranium Morphogenesis Presynaptic Endosome Regulation Of Lens Fiber Cell Differentiation Respiratory System Development Calcium Ion Transport Outer Ear Morphogenesis Establishment Of Organelle Localization Retromer Complex Binding Thrombin-activated Receptor Signaling Pathway	Regulation Of Platelet Activation Coagulation Blood Coagulation Hemostasis Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Protein Activation Cascade Regulation Of Body Fluid Levels Glycoprotein Ib-IX-V Complex Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Coagulation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Heparin Binding Protein Maturation Regulation Of Fibrinolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Extracellular Exosome Megakaryocyte Development Calcium Ion Transmembrane Import Into Cytosol Extracellular Space Defense Response To Symbiont Positive Regulation Of Fibrinolysis Defense Response To Other Organism Response To Other Organism Serine-type Peptidase Activity Regulation Of Biological Quality Regulation Of Wound Healing Cell Adhesion Serine-type Endopeptidase Activity Regulation Of Protein Localization To Nucleus Response To External Biotic Stimulus Regulation Of Response To Wounding Defense Response Protein Metabolic Process Regulation Of Cell Activation Regulation Of Multicellular Organismal Process Cell Killing Myeloid Cell Development Calcium Ion Transmembrane Transport Platelet Activation Neutrophil-mediated Killing Of Bacterium Extracellular Matrix Leukocyte Mediated Cytotoxicity Calcium Ion Transport Negative Regulation Of Multicellular Organismal Process